Njengeminyaka yesikhumba, kunokwehla komsebenzi we-physiologic. Lezi zinguquko zidonswa yizo zombili izinqolobane (i-chronogic) kanye ne-extertinic (ikakhulukazi i-UV-ezibangelwa). Ama-botanicals anikezela ngezinzuzo ezingaba khona ukulwa nezinye zezimpawu zokuguga. Lapha, siyabuyekeza Khetha ama-botanicals kanye nobufakazi besayensi ngemuva kwezimangalo zabo zokulwa nokuguga. Ama-botanicals anganikela ngokulwa nokuvuvukala, i-antioxidant, i-moisturizing, ukuvikelwa kwe-UV, neminye imiphumela. Ubuningi bama-botanicals lubalwe njengezithako ezimotweni ezithandwayo kanye nama-cosmeceuticals, kepha bambalwa kuphela abadingidwa lapha. Lokhu kwakhethwa ngokususelwa ekutholakaleni kwemininingwane yesayensi, intshisekelo yomuntu siqu yababhali, kanye nokwamukelwa "okucatshangwayo" kwemikhiqizo yamanje yezimonyo kanye nezama-cosmeceutical. Ama-botanicals abukezwa lapha afaka uwoyela we-argan, uwoyela kakhukhunathi, i-crocin, i-feverfew, itiye eliluhlaza, i-marigold, ipomegranate, ne-soy.
Amagama agqamile: i-botanical; anti-ukuguga; uwoyela we-argan; uwoyela kakhukhunathi; i-crocin; feverfew; itiye eliluhlaza; Marigold; amapomegranati; isosi
3.1. Amafutha e-Argan
3.1.1. Umlando, ukusetshenziswa, kanye nezicelo
U-Arganwoyela u-Amafutha ungowokuphela kweMorocco futhi ukhiqizwa kusuka kwimbewu ye-Argania Sponosa L. Isebenzisa okuningi kwendabuko okufana nokupheka, ukuphatha izifo zesikhumba, kanye nokunakekelwa kwesikhumba.
3.1.2. Ukwakheka kanye nendlela yokwenza isenzo
Amafutha e-Argan akhiwa ngamafutha angama-80% ama-monounsaturated fat kanye nama-20% ama-acid ama-acids agcwele futhi aqukethe ama-polyphenols, ama-tocopherols, ama-squalene, kanye ne-triterpene alcohol.
3.1.3. Ubufakazi besayensi
I-Argan Amafutha ngokwesiko isetshenziswe ngokwesiko eMorocco ukwehlisa imibala yobuso, kepha isisekelo sesayensi salesi simangalo asiqondakali ngaphambili. Esifundweni segundane, u-Arigan Amafutha avinjelwe amaseli we-tyrosinase kanye ne-dopachrome tautomerase ku-B16 Murne Munine melanoma, okuholela ekunciphiseni umthamo wethamo ngokuqukethwe kwe-melanin. Lokhu kuphakamisa ukuthi uwoyela wase-Argan kungenzeka abe inhibitor enamandla ka-melanin biosynthesis, kepha izivivinyo zokulawula ezingahleliwe (i-RTC) ezifundweni zabantu ziyadingeka ukuqinisekisa le-hypothesis.
I-RTC encane yabesifazane abangu-60 ye-post-menopausal iphakamise ukuthi ukusetshenziswa kwansuku zonke kanye / noma ukusetshenziswa kwe-topical kwamafutha akwa-Argan kuncishisiwe ukulahleka kwamanzi (okususelwa ku-R5 (ukunwebeka kwe-biologity) isikhathi (RRT) isikhathi sokuqalisa (RRT) (isilinganiso okuhlobene kakhulu nokuqina kwesikhumba). Amaqembu angenziwanga ngokungahleliwe ukuze adle noma uwoyela we-olive noma uwoyela we-argan. Womabili la maqembu afaka uwoyela we-argan esihlahleni esingakwesobunxele kuphela. Izilinganiso zithathwe ezinhlakeni ze-volar ezilungile nesokunxele. Ukuthuthuka kokunwebeka kubonwe kuwo womabili amaqembu esihlakaleni lapho uwoyela wase-Argan wasetshenziswa khona ngokugcwele, kodwa esihlakaleni lapho ama-argan uwoyela ayengasebenzi kuphela eqenjini edla i-argan edla kuphela [31]. Lokhu kuthiwa kufakwe okuqukethwe kwe-antioxidant kumafutha ase-Argan kuqhathaniswa namafutha omnqumo. Kuhlukaniswa ukuthi lokhu kungenxa yokuqukethwe kwayo kwe-vithamini e kanye ne-ferulic acid, eyaziwa ama-antioxidants.
3.2. Uwoyela kakhukhunathi
3.2.1. Umlando, ukusetshenziswa, kanye nezicelo
Amafutha kakhukhunathi asuselwa ezitsheni ezomisiwe zikaCocos Nucifera futhi zisebenzisa okuningi, zombili zomlando nezesimanje. Isetshenziswe njengephunga, isikhumba, kanye nomenzeli wesimo sezinwele, nakwimikhiqizo eminingi yezimonyo. Ngenkathi uwoyela kakhukhunathi unezinto eziningi eziphumayo, kufaka phakathi ukhukhunathi i-coconut, i-coconut acid, kanye ne-hydrogen coconut uwoyela, sizoxoxa ngokuthi izicelo zocwaningo, sizoxoxa ngokuthi izicelo zocwaningo ezihambisana kakhulu namafutha e-vonun coconut (vco), alungiselelwe ngaphandle kokushisa.
Kusetshenziswe uwoyela kakhukhunathi wokuswakama kwesikhumba sezinsana futhi kungahle kube yinzuzo ekwelashweni kwe-atopic dermatitis yawo womabili ama-atopic dermatitis kanye nemiphumela yawo engaba khona ku-staphylococcus aureus kanye nezinye izicubu zesikhumba ezigulini ze-atopic. Uwoyela kakhukhunathi ukhonjiswe ukwehlisa ikoloni le-S. aureus kwisikhumba sabantu abadala nge-atopic dermatitis e-RTC eyimpumputhe ephindwe kabili.
3.2.2. Ukwakheka kanye nendlela yokwenza isenzo
Amafutha kakhukhunathi akhiwa ngo-90-95% we-triglycerides (i-lauric acid, i-myric acid, i-caprylic acid, captric acid, kanye ne-palmitic acid). Lokhu kuhlukelweni amafutha amaningi we-Vehive Pege / izithelo, akhiwa kakhulu amanoni angafakwanga. Kusetshenziswe kakhulu i-triglycerides function ukucwilisa isikhumba njenge-emollient ngokuthopha imiphetho eyomile evuthiwe yamaCorneoCytes kanye nokugcwalisa izikhala phakathi kwazo.
3.2.3. Ubufakazi besayensi
Amafutha kakhukhunathi angathambisa isikhumba somile sokuguga. Amaphesenti angamashumi ayisithupha nambili ama-acid anamafutha e-VCO anobude obufanayo futhi ama-92% agcwele, okuvumela ukupakisha okunzima okuholela emthethweni omkhulu kunawo wonke amafutha omnqumo. Ama-triglycerides e-Coconut Amafutha aphulwe phansi ngama-lipases ku-flora yesikhumba ejwayelekile kuya ku-glycerin namafutha acid. I-Glycerin ihlekisa ngokuzithoba okunamandla, okuheha amanzi engxenyeni ye-ephermis ye-epidermis evela endaweni yangaphandle kanye nezingqimba zesikhumba ezijulile. Ama-acid anamafutha e-vco anokuqukethwe okuphansi kwe-linoleic acid, okuhambisana njengoba i-linoleic acid ingacasula esikhunjeni. Amafutha kakhukhunathi aphakeme kunamafutha amaminerali ekunciphiseni ithewu ezigulini ezine-atopic dermatitis futhi zisebenza futhi ziphephile njengamafutha amaminerali ekwelapheni i-xerosis.
I-Lauric acid, isandulelo se-monolaurin kanye nengxenye ebalulekile ye-vco, ingahle ibe nezakhiwo zokulwa nokuvuvukala, ikwazi ukuguqula ukwanda kwamaseli we-immune futhi ibe nesibopho kweminye imiphumela ye-antimicrobial ye-vco. I-VCO iqukethe amazinga aphezulu we-ferulic acid ne-p-coumisaric acid (zombili ama-acid acijile), kanye namazinga aphezulu ala ma-acidi e-phenolic ahlotshaniswa namandla akhuphukayo e-antioxidant. I-Phenolic Acid isebenza ngempumelelo ekulimaleni okubangelwe ngu-UV. Kodwa-ke, yize izicelo ezingamafutha kakhukhunathi zingasebenza njengesikrini se-sunscreen, ezifundweni ze-vitro ziphakamisa ukuthi zinikeza amandla amancane wokuvinjwa kwe-UV.
Ngaphezu kwemiphumela yayo yokuswakama kanye nemiphumela ye-antioxidant, amamodeli wezilwane aphakamisa ukuthi i-vco inganciphisa amanxeba wokuphulukisa isikhathi. Kubekhona izinga elikhuphukile lePepsin-Soluble Collagen (ephakeme e-Collagen Cross-Link-Links) kumanxeba aphathwa ama-vco aqhathaniswa nokulawulwa. I-Histopathology ikhombisa ukwanda kwe-fibroblast ekwakheni kanye ne-neovasculation kula manxeba. Izifundo eziningi ziyadingeka ukubona ukuthi ukusetshenziswa kwe-topical of vco kungakhuphula amazinga aseCallagen esikhunjeni esikhulile sesikhumba sabantu.
3.3. Ikhothethweni
3.3.1. Umlando, ukusetshenziswa, izimangalo
I-Crocin iyingxenye esebenzayo ye-saffron, ethathwe emhlangeni omisiwe weCrocus Sativus L. Saffron etshalwa emithini yendabuko ukunciphisa ukucindezelwa, ukuvuvukala, isifo sesibindi, nabanye abaningi.
3.3.2. Ukwakheka kanye nendlela yokwenza isenzo
I-Crocin ibhekele umbala wesafroni. I-Crocin nayo itholakala ezitsheni zensimu Jasminoides Ellis. Kuhlukaniswa njenge-carotenoid glycoside.
3.3.3. Ubufakazi besayensi
I-Croconi inemiphumela ye-antioxidant, ivikela ama-squlene ekulweni ne-peroxidation ebekwe ngu-UV, futhi ivimbele ukukhishwa kwama-medrator wokuvuvukala. Umphumela we-antioxidant ukhonjisiwe ku-vitro ass aclows ekhombisa umsebenzi ophakeme we-artioxidant uma kuqhathaniswa ne-vithamini C. Ngaphezu kwalokho, i-croconcits ivete ye-membrate i-merbrate futhi ivimbela ama-membrane ama-membrate afaka i-IL-8, i-TNF-α, ne-LTB4. Iphinde inciphe isisho sezakhi zofuzo eziningi ze-NF-κB ezixhomekeke kuyo. Ocwaningweni olusebenzisa ama-fibroblasts abuntu abunjiwe, i-crocin inciphise i-ROS ebiyelwe ngu-UV, yathuthukisa inkulumo ye-colriin ye-matrix ye-matrix ye-matrix yangaphandle, futhi yanciphisa inani lamaseli ane-phenotypes ngemuva kwemisebe ye-UV. Kunciphisa ukukhiqizwa kwe-ros kanye nemikhawulo apoptosis. I-Crocin yaboniswa ukucindezela i-ERK / MAPK / NF-REB / STAT Signaling Patways kumaseli we-hacat eVitro. Yize i-crocin inamandla njenge-cosmeceutical elwa nokuguga, i-compound is abile. Ukusetshenziswa kokuhlakazwa kwama-nanossuctured ye-LIPID kwabaphathi be-topical kuphenywe ngemiphumela ethembisayo. Ukunquma imiphumela ye-crocin eVivo, amamodeli wezilwane angeziwe kanye nezilingo zemitholampilo ezingahleliwe ziyadingeka.
3.4. Ivewu
3.4.1. Umlando, ukusetshenziswa, izimangalo
I-FEVFEW, i-Tanacetum parthetium, ingumuthi osetshenziswayo osetshenziselwe izinhloso eziningi emithini yabantu.
3.4.2. Ukwakheka kanye nendlela yokwenza isenzo
I-FeverFew iqukethe i-parthenolide, i-sactenone ye-lactone, engaba nesibopho seminye yemiphumela yayo yokulwa nokuvuvukala, ngokuvinjwa kwe-NF-IRB. Lokhu kuvinjwa kwe-NF-B kubonakala sengathi kuzimele ngemiphumela ye-antioxidant kaParthenoLide. IParthenoLide ibuye ikhombise imiphumela ye-anticancer emdlavuza wesikhumba e-UVB-okubangelwa yi-UVB nakwama-melanoma cell eVitro. Ngeshwa, i-parthenoLide ingabangela nokusabela komzimba, ama-blisters omlomo, kanye ne-dermatitis yokuxhumana ne-alrmatitis. Ngenxa yalokhu okukhathazayo, manje sekususwe ngaphambi kokuthi kufakwe umkhuhlane emikhiqizweni yezimonyo.
3.4.3. Ubufakazi besayensi
Ngenxa yezinkinga ezingaba khona ngokusetshenziswa kwe-parthenolide, eminye imikhiqizo yezimonyo yamanje equkethe i-feverfew isebenzisa i-feverfew ye-parthenolide - i-pd-feverfided (PD-FUVEWF), ethi ingenawo mahhala. I-PD-FUVEW ingathuthukisa umsebenzi we-endogenous DNA Esifundweni se-vitro, i-PD-feverfew ichazwe ukwakheka kwe-hydrogen peroxide ye-UV futhi yehlile ukukhishwa kwe-cytoxine okuvuvukala kwe-pro-inflammatotine. Ibonise imiphumela enamandla ye-antioxidant kunesiqhathaniso, i-Vitamin C, futhi yehlile i-UV-inythema e-RTC enesihloko esingu-12.
3.5. Itiye eliluhlaza
3.5.1. Umlando, ukusetshenziswa, izimangalo
Itiye eliluhlaza lidliwe ngezinzuzo zalo zezempilo eChina amakhulu eminyaka. Ngenxa yemiphumela yayo enamandla ye-antioxidant, kunentshisekelo ekuthuthukisweni kokwakhiwa kwezindawo eziqinile, ezivumayo.
3.5.2. Ukwakheka kanye nendlela yokwenza isenzo
I-Green Tea, evela eCamellia Sinensis, iqukethe amakhompiyutha amaningi we-bioactive anemiphumela elwa nokuguga, kufaka phakathi i-caffeine, amavithamini, nama-polyphenools. Ama-polyphenols amakhulu etiye eliluhlaza yiTallochins, ngokuqondile u-GalloCatechin, epigallocatechin (ECG), ne-EpigallolutEHin-3-Gallte (EGCG). I-Epigallocatechin-3-galtate ine-antioxidant, i-photoprotective, immunomodulatory, anti-angiogenic, kanye nezakhiwo zokulwa nokuvuvukala. I-Green Tea ibuye iqukethe amanani aphezulu we-flavonol glycoside kaempferol, emunca amandla esikhunjeni ngemuva kwesicelo se-topical.
3.5.3. Ubufakazi besayensi
I-Green Tea Extract inciphisa ukukhiqizwa kwe-racellular ros eVitro futhi sehlile i-necrosis ebiyengelwe yi-ros. I-Epigallocatechin-3-gallote (i-polyphenol yetiye eluhlaza) ivimbela ukukhishwa kwe-UV edonswa nge-hydrogen peroxide, icindezela ukuvuvukala kwe-MAPK, futhi kunciphise ukuvuvukala ngokwenza kusebenze i-NF-RESE. Usebenzisa isikhumba se-Ex Vivo kusuka kowesifazane oneminyaka engama-31 ubudala, isikhumba sihlelwe ngetiye elimhlophe noma eliluhlaza okhipha amaseli we-langen (amaseli angethula ama-antichen abhekele ukungeniswa kokungavikeleki esikhunjeni) ngemuva kokuvezwa kokukhanya kwe-UV.
Kwimodeli yegundane, ukusetshenziswa kwe-topical kokukhishwa kwetiye eliluhlaza ngaphambi kokuvezwa kwe-UV okuholwa ku-erythema okunciphile, kunciphise ukufakwa kwesikhumba kwama-leukocytes, kanye nokuncipha komsebenzi we-MYOLOXIDAse. Ingavimba futhi i-5-α-red-reductase.
Izifundo eziningana ezibandakanya izifundo zabantu ziye zahlola izinzuzo ezingaba khona zokusetshenziswa kwe-topical kwetiye eliluhlaza. Ukusetshenziswa kwe-Topical kwe-emulsion eluhlaza emulsion kuvinjelwe ama-5-α-reductase futhi kuholele ekunciphiseni usayizi we-microcomedone e-microcomedonal acre. Esifundweni esincane sobuso bobuso bobuso besithupha, ukhilimu oqukethe i-EGCG wehlise isici se-hypoxia-esingenakugwetshwa 1 α (Hif-1α) kanye ne-vascular endother Finest factor factor (vegf) nkulumo, kukhombisa amandla okuvimbela iTalangictasias. Esifundweni esingamampumputhe kabili, noma yitiye eliluhlaza, itiye elimhlophe, noma imoto isetshenziswa kuphela emabhukwini amavolonti angu-10 anempilo. Isikhumba sabe sesingaxhumisiwe nge-2 × minimal erythema dose (med) ye-UVR eyenziwe ngelanga. Isikhumba I-Biopsies kusuka kulezi zingosi ikhombise ukuthi ukusetshenziswa kwe-Green noma i-White Tea Extract kunganciphisa kakhulu ukuncipha kwamaseli we-langerhans, kususelwa ku-CD1A positivity ye-CD1A. Kube nokuvimbela okuyingxenye kokulimala kwe-oxidative ye-DNA ye-UV Esifundweni esihlukile, amavolontiya adala angama-90 angenziwa ngezikhathi ezithile abe ngamaqembu amathathu: akukho ukwelashwa, itiye eliluhlaza okotshani, noma itiye elimhlophe eliphansi. Iqembu ngalinye liphinde lahlukaniswa ngamazinga ahlukene wemisebe ye-UV. I-Vivo Super Propector yatholakala cishe i-SPF 1.
3.6. Isakhijoso
3.6.1. Umlando, ukusetshenziswa, izimangalo
I-Marigold, i-calendula officinalis, isitshalo esiqhakaza esiphuphumayo esinamathuba angaba khona wezokwelapha. Kusetshenziswe emithini yabantu eYurophu nase-United States njengendlela etholwayo yokushiswa, ukulimala, ukusikeka, kanye nemigoqo. I-Marigold ibuye ikhombise imiphumela yezimpikiswano eMurine amamodeli omdlavuza wesikhumba ongawona i-melanoma.
3.6.2. Ukwakheka kanye nendlela yokwenza isenzo
Izakhi zamakhemikhali eziphambili ze-marigolds ngama-steroid, ama-terpenoids, amahhala kanye ne-triterpene ye-triterpene alcohols, ama-phenonolic acid, ama-flavonoids, nezinye izinhlanganisela. Yize ucwaningo olulodwa lubonise ukuthi ukusetshenziswa kwe-topical of Marigold Surdact kunganciphisa ubulukhuni nobuhlungu besikhumba seziguli ezigulini ezithola imisebe yomdlavuza webele, ezinye izivivinyo zemitholampilo zikhombise ukuphakama komdlavuza webele kuphela.
3.6.3. Ubufakazi besayensi
UMarigold unemiphumela emibi ekhombisa amandla e-antioxidant kanye nemiphumela ye-cytotoxic kumaseli womdlavuza wesintu eVitro somuntu cell cell. Ngokwehlukile kocwaningo lwe-vitro, ukhilimu oqukethe uwoyela we-calendula wahlolwa nge-UV spectrophotometric futhi wathola ukuba ne-spectrum yokudonsa ebangeni le-290-320 nm; Lokhu kwathathwa njengokusho ukuthi ukusetshenziswa kokhilimu kwanikela ngokuvikelwa kwelanga okuhle. Kubalulekile ukuqaphela, noma kunjalo, ukuthi lokhu kwakungeyona isivivinyo se-vivo esibalwe umthamo omncane we-erythera kumavolontiya abantu futhi awenzanga ukuthi lokhu kuzokwenzanjani ekulingweni kwemitholampilo.
Emodeli ye-Vivo Murine, okukhishwe ngoMarigold kwakhombisa umphumela oqinile we-antioxidant ngemuva kokuvezwa kwe-UV. Ocwaningweni oluhlukile, okubandakanya amagundane e-albino, ukusetshenziswa kwe-calendula uwoyela obalulekile kwehlisiwe (umaki wengcindezi ye-oxidative) ngenkathi ukhulisa amazinga we-catalase, i-glutathione, i-superoxide dismutase, ne-ascorbic acid esikhunjeni.
Esifundweni esingamasonto ayisishiyagalombili aphuphuthekiswe nezifundo ezingama-21, ukusetshenziswa kwe-calendula ukhilimu kukhuphuke ukuqina kwesikhumba kepha kwakungenamiphumela ebalulekile ekubumbeni kwesikhumba.
Ukulinganiselwa okungaba khona kokusetshenziswa kwe-marigold kwezimonyo ukuthi i-marigold iyimbangela eyaziwayo ye-alrmatitis yokuxhumana ne-allergic, njengamanye amalungu ambalwa omndeni wakwaCompositae.
3.7. Isipomegranate
3.7.1. Umlando, ukusetshenziswa, izimangalo
I-Pomegranate, i-Puran Granatum, inekhono elinamandla le-antioxidant futhi lisetshenziswe emikhiqizweni eminingi njenge-antioxidant ethosiwe. Okuqukethwe kwalo okuphezulu kwe-antioxidant kwenza kube yisithako esingahle sithakazelise ekwakhiweni kwezimonyo.
3.7.2. Ukwakheka kanye nendlela yokwenza isenzo
Izakhi ezisebenzayo ze-poological ofpomegranate zingama-tannins, ama-anthocyanins, ascorbic acid, niacin, potassium, kanye ne-piperidine alkaloids. Lezi zinto ezisebenzayo ngokwemvelo zingakhishwa kwijusi, imbewu, amakhasi, amagxolo, izimpande, noma isiqu sepomegranate. Ezinye zalezi zinto kucatshangwa ukuthi zinama-antitumore, anti-ukuvuvukala, anti-microbial, antioxidant, kanye nemiphumela ye-photoprotateve. Ngaphezu kwalokho, i-Pomegranate ingumthombo onamandla wama-polyphenols. I-Elegic acid, ingxenye yepomegranate ekhishwe, inganciphisa imibala yesikhumba. Ngenxa yokuba yisithako esithembisayo esidala, izifundo eziningi ziphenye izindlela zokukhulisa ukungena kwesikhumba kwale nhlanganisela yokusebenzisa okuphezulu.
3.7.3. Ubufakazi besayensi
Izithelo ezikhishwe izithelo ezingamapomegranati zivikela ama-fibroblasts abantu, e-vitro, kusukela ekufeni kweseli e-Uv-okubangelwa; Cishe ngenxa yokuvuselelwa okuncishisiwe kwe-NF-IRB, ukwehla kwe-Propeapoptotic Caspace-3, kanye nokulungiswa kwe-DNA. Kukhombisa i-anti-skin-smon-smomulo imiphumela ekhuthaza e-vitro futhi ivimbela ukuguquguquka okubangelwa kwe-UVB kwe-NF-κb kanye neMepk. Ukusetshenziswa kwe-Topical of Pomegranate Rind Extract DowReculates COX-2 esikhunjeni esisanda kukhishwa endaweni, okuholela emiphumeleni ebalulekile yokulwa nokuvuvukala. Yize i-Ellegic acid ivame ukucatshangelwa ukuthi iyingxenye esebenzayo kakhulu ye-Pomegranate ekhishwe, imodeli ye-murine ekhombise umsebenzi ophakeme wokulwa nokuvuvukala nge-Pomegranate Rind extract ekhishwe ne-ElleGic acid ilona kuphela. Ukusetshenziswa okuphezulu kwe-microemulsion of Pomegranate ekhishwe usebenzisa i-polyysorbate survit (phakathi kwama-80®) ngokuqhathanisa okuhlukaniswa kobuso amasonto ayi-12 ngezihloko eziyi-11, kuboniswe i-melanin ye-tyrosinase) futhi kuncishiswe i-erythema yokuvimbela imoto.
3.8. Isosi
3.8.1. Umlando, ukusetshenziswa, izimangalo
Ama-soybeans anokudla okuphezulu kwamaprotheni anezinto ezi-bioactive ezingaba nemiphumela yokulwa nokuguga. Ikakhulu, ama-soya aphezulu e-isoflavines, engahle abe nemiphumela ye-anticarcinogenic nemiphumela efana ne-estrogen ngenxa yesakhiwo se-diphenolic. Le miphumela efana ne-estrogen ingaba nentukuthelo eminye imiphumela yokuya esikhathini ngokuguga kwesikhumba.
3.8.2. Ukwakheka kanye nendlela yokwenza isenzo
I-Soy, kusuka ku-Glycine Maxi, iphakeme ngamaprotheni futhi iqukethe i-isoflagones, kufaka phakathi i-glycitein, i-equol, uDaidzein neGenistein. Lezi zinto ze-isoflagones, ezibizwa nangokuthi ama-phytoectogens, angaba nemiphumela ye-estrogenic kubantu.
3.8.3. Ubufakazi besayensi
Ama-soybeans aqukethe ama-isoflavines amaningi anezinzuzo ezingaba khona zokulwa nokuguga. Phakathi kweminye imiphumela ye-biologic, i-glycitein ikhombisa imiphumela ye-antioxidant. Ama-Dermal Fibroblasts aphathwe nge-Glycitein akhombise ukwanda kwengxabano kanye nokufuduka kweseli, ukwanda kokuhlanganiswa kwezinhlobo ezi-collagen I neii, futhi kwehlisiwe i-MMP-1. Ocwaningweni oluhlukile, ukukhishwa kwesoya kwahlanganiswa ne-haematococcus extract (i-angae yamanzi ahlanzekile futhi ephezulu kakhulu e-antioxidants), i-MMMA ne-Mrna kanye ne-Protein Express. UDaidzein, i-soy isoflavone, ukhombisile ukubhala, ukukhanyisa isikhumba, kanye nemiphumela yezikhumba. I-Diadlein ingasebenza ngokwenza i-estrogen-ββ esikhunjeni, okuholele enkulumo ethuthukisiwe yama-antioxidant endoxenous futhi yehlise ukuvezwa kwezinto zokubhala eziholela ekwandeni kwe-keratinocyte nokufuduka. I-soy-derived isoflavonoid equol yandise i-collagen kanye ne-elastin futhi yehlile ama-MMPs kuma-cell coute.
Ezengeziwe eVivo Murine Study show yehlisiwe Ukufa kwe-UVB-okubangelwa yi-UVB kanye nobukhulu obunciphile kumaseli ngemuva kokusetshenziswa kwe-topical kokukhishwa kwe-isoflavone. Esifundweni somshayeli we-postmenopausal Advermeasausal, Ukuphathwa ngomlomo kwe-isoflavone ekhishwe izinyanga eziyisithupha kuholele ekukhulumeni kwe-epidermal okukhuphukile kanye nokwanda kwe-dermal collagen njengoba kulinganiswa ngezindawo ezivikelwe yilanga. Ocwaningweni oluhlukile, ahlanjululwe ama-soy isoflavoones avinjelwe ukufa kwe-keratinocyte efakiwe kwe-UV futhi anciphile tuws, ubukhulu be-ephermermal, kanye ne-erythema esihlahleni segundane elivezwe i-UV.
I-RCT ephethwe kabili yabesifazane abangu-30 abaneminyaka engama-45-55 baqhathanisa ukusetshenziswa kwe-topical of estrogen ne-genistein (soy isoflavone) esikhunjeni amasonto angama-24. Yize leli qembu lisebenzisa i-estrogen esikhunjeni lalinemiphumela ephakeme, womabili la maqembu akhombisa ukwanda kohlobo lwe-I neii collagen i-collagen ye-III esekelwe esikhunjeni se-biopsies yesikhumba. Ama-Soy Oligopepdes anganciphisa inkomba ye-erythema e-UVB-expred Skin (Forearm) futhi anciphise amaseli we-sunburn kanye nama-cyclobutene pyrimidine ama-foreskin cell e-UVB-infladiated cell ex vivo. Isivivinyo somtholampilo esingenakuqhathaniswa nemitholampilo esingahleliwe esingu-12 esibandakanya izifundo zabesifazane ezingama-65 ngokulinganisela kobuso be-PhotoDamage bakhombise ukuthuthuka ku-pigmentation emaphethelweni, ama-blotchiness, ama-dullness, imigqa emihle, ukuthungwa kwesikhumba, kanye nethoni yesikhumba uma kuqhathaniswa nemoto. Ngokubambisana, lezi zinto zinganikeza imiphumela engaba khona yokulwa nokuguga, kepha izivivinyo zemitholampilo ezinamandla ezinamandla zidingeka ukukhombisa ngokwanele inzuzo yayo.
4. Ingxoxo
Imikhiqizo ye-botanical, kufaka phakathi lezo okuxoxwe ngazo lapha, yiba nemiphumela yokulwa nokuguga. Izindlela zokulwa nama-botanicals angu-anti-aguga afaka amathuba okubalwa kwamahhala asetshenzisiwe afakiwe, ukuvikelwa kwelanga, ukugqugquzelwa kwe-Skin-Skin, kanye nemiphumela eminingi eholela ekwakheni ukwakheka kwe-collagen noma okwehlisiwe. Eminye yale miphumela inesizotha uma iqhathaniswa nemithi, kepha lokhu akunciphisi inzuzo yawo engaba khona lapho isetshenziswa ngokuhambisana nezinye izindlela ezinjengokuvinjelwa kwelanga, ukushukunyiswa kwelanga kanye nokwelashwa okufanele kwezokwelapha kwezimo zesikhumba ezikhona.
Ngaphezu kwalokho, ama-botanicals anikela ngezinye izithako ezisebenzayo zemvelo ezisebenzayo ezigulini ezithanda ukusebenzisa izithako "zemvelo" esikhunjeni sazo. Yize lezi zithako zitholakala emvelweni, kubalulekile ukugcizelela iziguli ukuthi lokhu akusho ukuthi lezi zithako zinemiphumela emibi ye-zero imiphumela, eqinisweni, imikhiqizo eminingi ye-botanical iyaziwa ukuthi iyimbangela ye-dermatitis yokuxhumana ne-alealic.
Njengoba imikhiqizo yezimonyo ayidingi inani elifanayo lobufakazi ukufakazela ukusebenza ngempumelelo, kuvame ukuba nzima ukuthola ukuthi izimangalo zemiphumela yokulwa nokuguga ziyiqiniso. Ama-botanicals amaningi abhalwe lapha, noma kunjalo, anemiphumela engaba khona yokulwa nokuguga, kepha kudingeka izivivinyo zomtholampilo eziqinile. Yize kunzima ukubikezela ukuthi laba bantu basebenza ngokuqondile bazuze kanjani ngokuqondile iziguli nabathengi ngokuzayo, kungenzeka ukuthi iningi lale mikhiqizo yokuphepha lizoqhubeka nokulethwa imikhiqizo yokunakekelwa kwesikhumba futhi uma zigcina zibe yingxenye yezindlela zokunakekelwa kwesikhumba, zizohlala ziyingxenye yezindlela zokunakekelwa kwesikhumba, zihlinzeka ngezinzuzo ezincane zempilo yesikhumba. Inani elilinganiselwe lalaba bantu be-botanical, noma kunjalo, umthelela omkhulu kubantu obujwayelekile angatholwa ngokuqinisa ubufakazi besenzo sabo semvelo, ngokulandela imigomo evamile ye-biomarker futhi ngemuva kwalokho okuthembela kakhulu ekuhlolweni kwesivivinyo somtholampilo.
Isikhathi sePosi: Meyi-11-2023
