I. Isingeniso
I-Turkey Tail Extract, ephuma ku-Trametes versicolor mushroom, iyinto yemvelo ethakazelisayo ethathe isithakazelo sabacwaningi kanye nabathandi bezempilo ngokufanayo.Lesi siqephu, esiphinde saziwa ngegama laso lesayensi i-Coriolus versicolor, sihlonishwa ngenxa yezindawo zokuphulukisa ezingase zibe khona futhi sinomlando omude wokusetshenziswa ezinhlelweni zemithi yendabuko kuwo wonke amasiko ahlukene.Ngaphakathi komphakathi wesayensi, kukhona ukwazisa okukhulayo ngezinhlanganisela ze-bioactive ezitholakala ku-Turkey Tail Extract, okukholakala ukuthi zineqhaza emiphumeleni yayo yokwelapha.Njengoba isithakazelo emakhambi emvelo siqhubeka sikhula, kubaluleke kakhulu ukutadisha izici zokwelapha ze-Turkey Tail Extract ukuze uthole amandla ayo aphelele futhi ekugcineni kuzuze impilo yabantu.
II.Ukusetshenziswa Kwendabuko Kwe-Turkey Tail Extract
I-Turkey Tail Extract, eyaziwa nangokuthiI-Coriolus versicolor, inomlando ocebile wokusetshenziswa kwendabuko emasikweni ahlukahlukene, lapho iye yaziswa khona ngezici zayo zokuphulukisa ezingase zibe khona.Amarekhodi omlando aveza ukuthi lokhu kukhishwa bekusetshenziswa ezinhlelweni zemithi yendabuko yonkana e-Asia, eYurophu, naseNyakatho Melika amakhulu eminyaka, kugcizelela ukubaluleka kwayo okuhlala njalo ezimweni ezihlukahlukene zamasiko.E-China yasendulo, i-Turkey Tail Extract yayisetshenziswa njenge-tonic yokuthuthukisa ubungqabavu nokukhuthaza inhlalakahle jikelele.Umuthi wendabuko waseShayina uthi unamandla okusekela izivikelo zemvelo zomzimba nokubuyisela ibhalansi.Ngokufanayo, emithini yesintu yaseJapane, i-Turkey Tail Extract yayihlonishwa ngenxa yezakhiwo zayo zokuqinisa amasosha omzimba futhi yayivame ukuhlanganiswa namakhambi endabuko.Ngaphezu kwalokho, emasikweni endabuko aseNyakatho Melika, izinzuzo ze-Turkey Tail Extract zaqashelwa, futhi yasetshenziswa njengokwelapha okungokwemvelo kwezifo ezihlukahlukene, okubonisa indima yayo ebalulekile emikhubeni yokwelapha yendabuko.
Ukubaluleka kwamasiko kweTurkey Tail Extract kugxilile ezinkolelweni nasezinkambisweni zezifunda ezihlukahlukene, okubonisa ukuxhumana komlando nokomoya phakathi kwabantu nomhlaba wemvelo.Emiphakathini yendabuko eNyakatho Melika, ikhowe le-turkey tail libaluleke ngendlela engokomfanekiso futhi lihlonishwa ngokuhlotshaniswa kwalo nempilo, ukuphila isikhathi eside, nokuphila kahle ngokomoya.Kulawa masiko, imibala egqamile yamakhowe namaphethini ayinkimbinkimbi kukholakala ukuthi ahlanganisa amandla nobungqabavu bendawo yemvelo, okulenza libe uphawu olunamandla lokukhuthazela nokuxhumana.Ngaphezu kwalokho, emasikweni ase-Asia, ukusetshenziswa komlando kwe-Turkey Tail Extract kuye kwahlanganiswa nezimiso zokulinganisela nokuvumelana, ukuhambisana nezindlela zendabuko eziphelele zezempilo nokuphila kahle.Ukubaluleka okuhlala njalo kwamasiko kwe-Turkey Tail Extract kugcizelela inhlonipho ejulile imiphakathi eyahlukene ebinayo ngaleli khambi lemvelo kuwo wonke umlando, okuvusa isithakazelo esiqhubekayo sokuhlola izici zayo zokuphulukisa ezingase zibe khona.
Ukusetshenziswa komlando kanye nokubaluleka kwamasiko kwe-Turkey Tail Extract kunikeza ukuqonda okubalulekile ekuthakaseleni okuhlala njalo nezindawo zayo zokuphulukisa okuhloswe ngazo kanye nokusebenzisana okuhlala njalo phakathi kwemvelo nenhlalakahle yomuntu.Njengoba intshisekelo emakhambi emvelo iqhubeka ikhula, ukubaluleka kokuvuma nokuhlola ukusetshenziswa kwendabuko kanye nokubaluleka kwamasiko kwe-Turkey Tail Extract kuba sobala kakhulu.Izimo ezihlukahlukene zomlando namasiko zokusetshenziswa kwalo zisebenza njengobufakazi benani elihlala njalo elibekwe kuleli khambi lemvelo, likhuthaza ukuhlola okuqhubekayo nokucwaninga ngezinzuzo zalo zokwelapha ezingaba khona.Ngokuhlolisisa umlando namasiko we-Turkey Tail Extract, singathola ukwazisa okujulile ngezici zayo zokuphulukisa ezingase zibe khona futhi sivule indlela yokuqonda okubanzi kwendima yayo ekukhuthazeni impilo nempilo yabantu.
III.Ucwaningo Lwesayensi nge-Turkey Tail Extract
Ucwaningo lwesayensi lwe-Turkey Tail Extract luthuthuke ekuqondeni kwethu izinzuzo zezempilo ezingaba khona ezitholakala kule nhlanganisela yemvelo.Njengoba ucwaningo oluningi luye lwahlola ukwakheka kwamangqamuzana kanye nemiphumela yomzimba, kuye kwavela ingcebo yemiphumela esekela indima yayo njenge-ejenti yokwelapha ebalulekile.Izinhlanganisela ze-bioactive ezikhona ku-Turkey Tail Extract, njenge-polysaccharides, i-polysaccharides, ne-triterpenoids, kube yisizinda socwaningo, eveza i-tapestry ecebile yezakhiwo ezisekela ukubaluleka kwayo kwezokwelapha.Le webhu eyinkimbinkimbi yezakhi zamakhemikhali iye yaphenywa ngezindima zayo ekulungiseni isimiso somzimba sokuzivikela ezifweni, ukulwa nengcindezi ye-oxidative, kanye nokunciphisa ukuvuvukala, okubeka isiteji sokuhlolwa okujulile kwamandla ayo okuphulukisa.
Emkhakheni wocwaningo lwesayensi, izifundo ezikhona zikhanyisele izakhiwo ze-Turkey Tail Extract, zembula amandla ayo okuqinisa izindlela zokuzivikela zomzimba.Ngokukhuthazwa kwamangqamuzana omzimba omzimba kanye nokuguqulwa kwezimpendulo zokuzivikela komzimba, lokhu kukhishwa kwemvelo kubonise isithembiso ekuqiniseni isimiso somzimba sokuzivikela ezifweni nasekuthuthukiseni impilo yonke.Ngaphezu kwalokho, ucwaningo lwembule izakhiwo zalo ezinamandla ze-antioxidant kanye ne-anti-inflammatory, olunikeza amazwibela amandla ayo okulwa nemiphumela eyingozi yokulimala kwe-oxidative kanye nokuvuvukala okungapheli.Kusukela ezifundweni zamaselula kuye kumamodeli ezilwane, ubufakazi busekela umbono wokuthi i-Turkey Tail Extract inamandla amakhulu okuthuthukisa impilo kahle kanye nokubhekana nenqwaba yokukhathazeka ngezempilo.
Izinzuzo zezempilo ezingaba khona ezisekelwa ucwaningo zihlanganisa uhla olubanzi lwemiphumela engokomzimba egcizelela ukuguquguquka kwe-Turkey Tail Extract njengento yokwelapha.Izakhiwo ze-antiviral kanye ne-antibacterial ezibhaliwe zalesi siqeshana zikhomba amandla ayo okulwa nezifo kanye nokuqinisa umzimba ngokumelene nabahlaseli be-microbial.Ngaphezu kwalokho, indima yayo ekudambiseni ukuqhubeka kwezinhlobo ezithile zomdlavuza ivuse isasasa elikhulu, yayibeka njengokwelapha okuphoqelekile endaweni ye-oncology.Ukuhlola umthelela wawo empilweni yamathumbu, i-gut microbiota, nokusebenza kwesibindi nakho kube nomthelela endaweni yocwaningo egcizelela ubunjalo obunezici eziningi bezakhiwo zayo zokwelapha.Njengoba uphenyo lwesayensi lujula emandleni okwelapha e-Turkey Tail Extract, umbono wokusebenzisa izinzuzo zawo empilweni yabantu ukhula uthembisa kakhulu.
IV.Izithako Ezisebenzayo e-Turkey Tail Extract
Izithako ezisebenzayo ezitholakala ku-Turkey Tail Extract zizuze ukunakwa okubalulekile kwezindawo zazo zokuphulukisa ezingase zibe khona.Ngokuhlaziywa kwamakhemikhali okuphelele, abacwaningi bahlonze izinhlanganisela ezibalulekile ezifaka inani lokwelapha lalesi sici semvelo.Ama-Polysaccharides, ama-polysaccharides, nama-triterpenoids aphakathi kwezakhi ezivelele ze-bioactive ezikhona eTurkey Tail Extract, ngayinye ihlinzeka ngohlu oluhlukile lwezakhiwo zokwelapha ezithathe isithakazelo somphakathi wesayensi.
I-Polysaccharopeptides, eyaziwa ngemiphumela yayo yokuzivikela komzimba, ikhonjiswe ukuthi ivuselela futhi ithuthukise umsebenzi wamangqamuzana omzimba omzimba, okungenzeka iqinise izindlela zokuzivikela zemvelo zomzimba.Lezi zinhlanganisela zinesithembiso ekusekeleni amasosha omzimba futhi zingadlala indima ebalulekile ekugcineni impilo nempilo yonke.Ukwengeza, i-polysaccharides etholakala ku-Turkey Tail Extract iye yaphenywa ngenxa yezakhiwo zayo ezinamandla zokulwa ne-antioxidant, ezingasiza ekulweni nama-radicals mahhala kanye nokucindezeleka okwenziwe nge-oxidative, ngaleyo ndlela ivikele amangqamuzana emonakalweni futhi ibe nomthelela emiphumeleni eminingi yezempilo, kuhlanganise nemiphumela yokulwa nokuguga nokuvimbela izifo.
I-Triterpenoids, elinye ikilasi lama-bioactive compounds atholakala ku-Turkey Tail Extract, athole ukunakwa kwamandla abo okulwa nokuvuvukala kanye nokulwa nomdlavuza.Lezi zinhlanganisela ziye zabonisa ikhono lokulinganisa izindlela zokuvuvukala, ezinikeza isithembiso sezimo ezibonakala ngokuvuvukala okungapheli.Ngaphezu kwalokho, ucwaningo luye lwabonisa ukuthi ama-triterpenoid angase abe nemiphumela ye-anticancer ngokusebenzisa izindlela ezihlukahlukene, okuwenza abe isihloko esithakaselwa kakhulu emkhakheni we-oncology.Njengoba umphakathi wesayensi uqhubeka nokungena ezicini eziyinkimbinkimbi zalezi zinhlanganisela ezibalulekile ku-Turkey Tail Extract, imithelela engase ibe khona empilweni yomuntu kanye nokuphathwa kwezifo iyindawo yokuhlola okuqhubekayo nokutholakala.
V. Izicelo Kwezokwelapha Zanamuhla
I-Turkey Tail Extract ibilokhu igxile ocwaningweni olunzulu ngenxa yezicelo zayo ezingase zibe khona kwezokwelapha zesimanje.Ukusetshenziswa kwamanje nokungase kube khona ekunakekelweni kwezempilo kuhlanganisa izinzuzo eziningi zokwelapha, okuhlanganisa ukuguquguquka komzimba, imiphumela elwa nokuvuvukala, izakhiwo ze-antioxidant, kanye nomsebenzi ongase ube khona wokulwa nomdlavuza.Izivivinyo zemitholampilo kanye nemithi esekelwe ebufakazini idlala indima ebalulekile ekuqinisekiseni lokhu kusetshenziswa nasekulungiseni ukuqonda kwethu izici zokuphulukisa ze-Turkey Tail Extract.
Emkhakheni wezokunakekelwa kwempilo, i-Turkey Tail Extract ibonise isithembiso ekusekeleni umsebenzi wokuzivikela komzimba, okwenza kube umngane ongase abe umsizi ekulawuleni izimo ezihlukahlukene ezihlobene nokuzivikela komzimba.Ucwaningo luphakamisa ukuthiama-polysaccharopeptidesekhona eTurkey Tail Extract ingashintsha amasosha omzimba, ithuthukise ikhono layo lokulwa nezifo nezinye izifo ezihlobene nokuzivikela komzimba.Ngaphezu kwalokho, i-izakhiwo ze-antioxidantkokukhishwa kungase kube nomthelela empilweni yonke, engase inikeze imiphumela yokuzivikela ezifweni ezihlobene nokucindezeleka okwenziwe nge-oxidative.
Izivivinyo zemitholampilo zinikeze ukuqonda okubalulekile ekusetshenzisweni okungaba khona kwe-Turkey Tail Extract ekwelapheni nasekuvimbeleni umdlavuza.Ucwaningo luye lwahlola amandla ayo okuhambisana nokwelashwa komdlavuza wendabuko ngemiphumela yawo ye-immunomodulatory kanye namandla ayo okuvimbela ukukhula kwesimila.Ubufakazi obuvela kulezi zivivinyo buphakamisa ukuthi i-Turkey Tail Extract ingase iqinisekise uphenyo olwengeziwe njengokwelashwa okuhambisanayo ekunakekelweni komdlavuza.
Ngaphezu kwalokho, i-anti-inflammatorykanye namandla okulwa nomdlavuza we-triterpenoid atholakala eTurkey Tail Extract kuye kwavusa isithakazelo sabacwaningi.Izivivinyo zemitholampilo zibalulekile ekucaciseni izindlela zokwenza kanye nokuhlola ukuphepha nokusebenza ngempumelelo kwalezi zinhlanganisela ze-bioactive.Njengoba indikimba yobufakazi iqhubeka ikhula, odokotela nabacwaningi bangaqhubeka behlola amandla e-Turkey Tail Extract ekulawuleni izimo ezivuthayo kanye nendima yayo engenzeka ekuthuthukiseni ukungenelela kokwelapha okunoveli.
Sengiphetha, ukusetshenziswa kwamanje nokungase kube khona kwe-Turkey Tail Extract kwezokwelapha zesimanje kuletha umngcele othokozisayo ekunakekelweni kwezempilo.Izivivinyo zomtholampilo eziqinile kanye nemithi esekelwe ebufakazini ibalulekile ekuqinisekiseni izinhlelo zayo zokwelapha kanye nokuvula indlela yokuhlanganiswa kwayo emikhubeni yokunakekelwa kwezempilo evamile.Njengoba ucwaningo lwalo mkhakha luthuthuka, izakhiwo zokuphulukisa ze-Turkey Tail Extract zingase zibe nesithembiso esibalulekile sokuthuthukisa impilo kanye nokuphila kahle kwabantu.
VI.Ukuthuthukisa Amandla e-Turkey Tail Extract
Amathuba ocwaningo olwengeziwe endaweni yeTurkey Tail Extract maningi, anezindlela zokuhlola ezihlanganisa imikhakha yezokwelapha ehlukahlukene kanye nezicelo.Ukuphenya ngendima yayo engaba khona ezinkingeni ze-autoimmune, izifo ezithathelwanayo, nokuvuvukala okungapheli kuveza amathemba ajabulisayo, ikakhulukazi uma kubhekwa izici zayo zokuzivikela komzimba kanye nokulwa nokuvuvukala.Ukwengeza, ukuhlolisisa ukusebenzisana kwe-microbiological phakathi kweTurkey Tail Extract kanye ne-gut microbiota kungase kunikeze ukuqonda okubalulekile ezindleleni zayo zokusebenza kanye nezicelo ezingase zibe khona empilweni yamathumbu kanye nokuphazamiseka kokugaya ukudla.Ngaphezu kwalokho, ucwaningo ngemiphumela engaba khona ye-synergistic uma kuhlanganiswa nemithi yokwelapha evamile yomdlavuza nezinye izifo ezingelapheki lunganikeza idatha ebalulekile yokuthuthukisa izinqubo zokwelapha nokuthuthukisa imiphumela yesiguli.Ngakho-ke, ukuqhubeka nokuhlola ezindaweni eziningi zokwelapha zeTurkey Tail Extract kunesithembiso esibalulekile sokuthuthukisa ulwazi lwezokwelapha kanye nokwenza ngcono ukunakekelwa kwesiguli.
Ukucatshangelwa kokukhipha kanye nokwakhiwa kwe-Turkey Tail Extract kubalulekile ekwandiseni i-bioavailability yayo kanye nempumelelo yokwelapha.Ukukhethwa kwezindlela ezifanele zokukhipha, ezifana nokukhipha amanzi ashisayo noma ukukhipha utshwala, kudlala indima ebalulekile ekutholeni ukukhishwa okunamandla nokujwayelekile okunamazinga angaguquki ezinhlanganisela ze-bioactive.Ngaphezu kwalokho, ukwakhiwa kwe-Turkey Tail Extract ibe izinhlelo ezihlukahlukene zokulethwa, njengama-capsules, ama-tinctures, noma amalungiselelo e-topical, kudinga ukucatshangelwa ngokucophelela ukuze kuqinisekiswe ukuzinza, ukuphila kweshalofu, kanye nokulethwa okuphelele kwezinto zayo ezisebenzayo.Ukwengeza, ukuhlola amasu amasha, afana ne-nanoformulation noma i-encapsulation, kungase kunikeze i-bioavailability ethuthukisiwe kanye nokulethwa okuhlosiwe, ngaleyo ndlela kuthuthukise ukusebenza kahle okuphelele kwe-Turkey Tail Extract ekusetshenzisweni komtholampilo kanye nokwelapha.Ngakho-ke, ukunaka ngamabomu ukucutshungulwa nokucatshangelwa kokwakhiwa kubalulekile ukuze kusetshenziswe amandla aphelele e-Turkey Tail Extract kanye nokuhumusha izici zayo zokwelapha zibe ukungenelela kokwelapha okuphephile nokusebenzayo.
VII.Isiphetho
Kukho konke lokhu kuhlolwa kwe-Turkey Tail Extract, kuye kwaba sobala ukuthi le nto yemvelo inenqwaba yezinto zokuphulukisa.Ucwaningo lwesayensi luye lwabonisa imiphumela yalo enamandla yokuvikela amasosha omzimba, igqamisa amandla ayo okusekela umsebenzi wamasosha omzimba kanye nokusabela kumagciwane.Ngaphezu kwalokho, izakhiwo zayo zokulwa nokuvuvukala ziboniswe ukuthi zinemiphumela efinyelela kude ezimweni ezibonakala ngokuvuvukala okungapheli, okuhlanganisa ukuphazamiseka kwe-autoimmune kanye nesifo sokugaya ukudla.Umthamo we-antioxidant we-Turkey Tail Extract, njengoba kufakazelwa okuqukethwe kwayo okuphezulu kwama-phenolic compounds nama-polysaccharides, igcizelela amandla ayo ekwehliseni ukucindezeleka okwenziwe nge-oxidative kanye nemiphumela yayo yezempilo ehambisanayo.Ukwengeza, indima yayo njengokwelapha okuhambisanayo ekwelapheni umdlavuza isidale intshisekelo enkulu, ngocwaningo olukhombisa ikhono layo lokuthuthukisa ukusebenza ngempumelelo kwezindlela zokwelapha ezijwayelekile ngenkathi kunciphisa imiphumela yazo emibi.Sekukonke, izici zokuphulukisa ze-Turkey Tail Extract zihlanganisa uchungechunge olubanzi lwezinzuzo zomzimba kanye nokwelapha, okuyenza ibe isihloko esiphoqayo ukuze kuqhutshekwe nokuhlolwa futhi kusetshenziswe ezimweni zomtholampilo.
Imithelela yezakhiwo zokuphulukisa zeTurkey Tail Extract idlulela ngalé kwemingcele yolwazi olukhona kanye nezinhlelo zokusebenza.Amandla okusetshenziswa nokucwaninga esikhathini esizayo makhulu, anezindlela eziningi zokuhlola nokusungula izinto ezintsha.Emkhakheni wokuphazamiseka kwe-autoimmune, imiphumela ye-immunomodulatory ye-Turkey Tail Extract iveza amathuba okuthuthukiswa kokungenelela okuhlosiwe kokwelapha okuhloswe ukubuyisela ibhalansi yamasosha omzimba kanye nokunciphisa izifo ze-autoimmune.Ngokufanayo, izakhiwo zayo zokulwa nokuvuvukala zinikeza isithembiso sokuphathwa kwezimo ezingapheli zokuvuvukala, okunomthelela ezimeni ezifana nesifo samathambo, isifo sokuqaqamba kwamalunga, kanye nokuphazamiseka kwesikhumba.Imiphumela engaba khona ye-synergistic ye-Turkey Tail Extract ngokuhlanganyela nemithi evamile yokwelapha umdlavuza ayinikezi nje kuphela uphenyo olwengeziwe mayelana nendima yayo njengokwelashwa kwe-adjuvant kodwa futhi iphakamisa ithemba lezindlela zomuntu siqu nezihlanganisiwe zokunakekelwa komdlavuza.Ngaphezu kwalokho, ukusebenzisana kwe-microbiological phakathi kweTurkey Tail Extract kanye ne-gut microbiota kubonisa indawo ephoqelela yocwaningo enemithelela efinyelela kude yempilo yamathumbu, ukuphazamiseka kwe-metabolic, kanye nempilo yonke.Sekukonke, imithelela yokusetshenziswa kwesikhathi esizayo kanye nocwaningo igcizelela isidingo sokuqhubeka nokuhlola amandla okwelapha e-Turkey Tail Extract kuzo zonke izinhlobo zezifundo zezokwelapha nezinhlelo zokusebenza.
Izithenjwa:
1. Jin, M., et al.(2011)."Imiphumela yokulwa nokuvuvukala kanye ne-anti-oxidative yokukhishwa kwamanzi e-Turkey Tail mushroom (Trametes versicolor) nomsebenzi wayo wokulwa nomdlavuza ku-A549 kanye ne-H1299 imigqa yamangqamuzana omdlavuza wamaphaphu womuntu."I-BMC Complementary and Alternative Medicine, 11: 68.
2. Standish, LJ, et al.(2008)."I-Trametes versicolor mushroom immune therapy kumdlavuza webele."Ijenali ye-Society for Integrative Oncology, 6(3): 122–128.
3. Wang, X., et al.(2019)."Imiphumela ye-Immunomodulatory ye-polysaccharopeptide (PSP) kumaseli e-dendritic atholakala ku-monocyte."Ijenali yocwaningo lwe-Immunology, 2019: 1036867.
4. Wasser, SP (2002)."Amakhowe okwelapha njengomthombo we-antitumor kanye ne-immunomodulating polysaccharides."I-Microbiology esetshenziswayo kanye ne-Biotechnology, 60(3): 258–274.
Isikhathi sokuthumela: Dec-12-2023
