I-Thearubigins (TRs) iyiqembu lama-polyphenolic compounds atholakala etiyeni elimnyama, futhi athole ukunakwa ngendima yawo engaba khona ekulweni nokuguga. Ukuqonda izindlela ama-Thearubigins asebenzisa ngazo imiphumela yawo yokulwa nokuguga kubalulekile ekuhloleni ukusebenza kwawo kanye nezinhlelo zokusebenza ezingase zibe khona ekukhuthazeni ukuguga okunempilo. Le ndatshana ihlose ukuhlolisisa imininingwane yesayensi yokuthi iThearubigins isebenza kanjani ekulweni nokuguga, isekelwa ubufakazi obuvela ocwaningweni olufanele.
Izakhiwo zokulwa nokuguga ze-Thearubigins zingabalelwa emiphumeleni yazo enamandla ye-antioxidant kanye ne-anti-inflammatory. Ukucindezeleka okwenziwe nge-oxidative, okubangelwa ukungalingani phakathi kwama-radicals mahhala nama-antioxidants emzimbeni, kuwumshayeli oyinhloko wokuguga kanye nezifo ezihlobene neminyaka. I-Thearubigins isebenza njengama-antioxidants anamandla, isusa ama-radicals mahhala futhi ivikela amangqamuzana emonakalweni we-oxidative. Lesi sakhiwo sibalulekile ekuvimbeleni izimo ezihlobene neminyaka kanye nokukhuthaza impilo yonke nokuphila isikhathi eside.
Ngaphezu kwemiphumela yabo ye-antioxidant, i-Thearubigins ibonise izakhiwo eziqinile zokulwa nokuvuvukala. Ukuvuvukala okungapheli kuhlotshaniswa nokuguga kanye nezifo ezihlobene nobudala, futhi ngokunciphisa ukuvuvukala, i-Thearubigins ingase ibambe iqhaza elikhulu ekunciphiseni inqubo yokuguga nokunciphisa ingozi yezimo ezifana nesifo senhliziyo, isifo sikashukela, nokuphazamiseka kwe-neurodeergenerative.
Ngaphezu kwalokho, i-Thearubigins itholakale inemiphumela emihle empilweni yesikhumba nokubukeka. Ucwaningo luye lwabonisa ukuthi i-Thearubigins ingasiza ukuvikela isikhumba emonakalweni we-UV, ukunciphisa ukubukeka kwemibimbi, nokwenza ngcono ukunwebeka kwesikhumba. Lokhu okutholakele kusikisela ukuthi i-Thearubigins ingaba namandla njengesithako semvelo sokulwa nokuguga emikhiqizweni yokunakekelwa kwesikhumba, enikeza enye indlela ephephile nesebenzayo ekwelashweni okujwayelekile kokulwa nokuguga.
Izinzuzo zezempilo ezingaba khona ze-Thearubigins ekulweni nokuguga ziye zavusa isithakazelo ekusetshenzisweni kwazo njengesengezo sokudla. Nakuba itiye elimnyama liwumthombo wemvelo we-Thearubigins, ukugxila kwalezi zinhlanganisela kungahluka kuye ngezinto ezifana nezindlela zokucubungula itiye nezindlela zokuphuza utshwala. Ngenxa yalokho, kunesithakazelo esikhulayo ekuthuthukisweni kwezithako ze-Thearubigin ezinganikeza umthamo omisiwe walezi zinhlanganisela ezinamandla zokulwa nokuguga.
Kubalulekile ukuqaphela ukuthi nakuba i-Thearubigins ibonisa isithembiso njengama-anti-aging agents, ucwaningo olwengeziwe luyadingeka ukuze uqonde ngokugcwele izindlela zabo zokwenza kanye nemiphumela emibi engase ibe khona. Ukwengeza, i-bioavailability ye-Thearubigins kanye nomthamo wabo ophelele wezinzuzo zokulwa nokuguga kudinga uphenyo olwengeziwe. Noma kunjalo, indikimba ekhulayo yobufakazi obusekela izakhiwo zokulwa nokuguga ze-Thearubigins iphakamisa ukuthi ingaba namandla amakhulu okugqugquzela ukuguga okunempilo nokwandisa isikhathi sokuphila.
Sengiphetha, ama-Thearubigins (TRs) abonisa imiphumela elwa nokuguga ngokusebenzisa izakhiwo zawo ezinamandla ze-antioxidant, anti-inflammatory, kanye nesikhumba. Amandla abo okulwa nokucindezeleka okwenziwe nge-oxidative, ukunciphisa ukuvuvukala, nokuthuthukisa impilo yesikhumba kubabeka njengama-ejenti athembisayo ekulweni nokuguga kanye nezifo ezihlobene nobudala. Njengoba ucwaningo kule ndawo luqhubeka nokwanda, ukusetshenziswa okungenzeka kwe-Thearubigins ekukhuthazeni ukuguga okunempilo nokuphila isikhathi eside kungenzeka kubonakale ngokuqhubekayo.
Izithenjwa:
Khan N, Mukhtar H. Tea polyphenols ekukhuthazeni impilo yabantu. Izakhamzimba. 2018;11(1):39.
McKay DL, Blumberg JB. Indima yetiye empilweni yomuntu: isibuyekezo. J Am Coll Nutr. 2002;21(1):1-13.
Mandel S, Youdim MB. I-Catechin polyphenols: i-neurodegeneration kanye ne-neuroprotection ezifweni ze-neurodeergenerative. Mahhala Radic Biol Med. 2004;37(3):304-17.
I-Higdon JV, Frei B. I-catechins yetiye nama-polyphenols: imiphumela yezempilo, i-metabolism, nemisebenzi ye-antioxidant. I-Crit Rev Food Sci Nutr. 2003;43(1):89-143.
Isikhathi sokuthumela: May-10-2024