Ama-Thearubigin (ama-TR) ziyiqembu lama-polyphenolic compounds atholakala etiyeni elimnyama, futhi athole ukunakwa ngendima yawo engaba khona ekulweni nokuguga. Ukuqonda izindlela ama-Thearubigins asebenzisa ngazo imiphumela yawo yokulwa nokuguga kubalulekile ekuhloleni ukusebenza kwawo kanye nezicelo zawo ezingaba khona ekukhuthazeni ukuguga okunempilo. Lesi sihloko sihlose ukuhlolisisa ukuqonda kwesayensi ngemuva kokuthi ama-Thearubigins asebenza kanjani ekulweni nokuguga, okusekelwa ubufakazi obuvela ocwaningweni olufanele.
Izakhiwo zokulwa nokuguga ze-Thearubigins zingabangelwa yimiphumela yazo enamandla yokulwa nokuguga kanye nemiphumela yokulwa nokuvuvukala. Ukucindezeleka kwe-oxidative, okubangelwa ukungalingani phakathi kwama-free radicals nama-antioxidants emzimbeni, kuyimbangela eyinhloko yokuguga kanye nezifo ezihlobene nokuguga. Ama-Thearubigins asebenza njengama-antioxidants anamandla, esusa ama-free radicals futhi evikela amaseli ekulimaleni kwe-oxidative. Le mfanelo ibalulekile ekuvimbeleni izimo ezihlobene nokuguga kanye nokukhuthaza impilo yonke kanye nokuphila isikhathi eside.
Ngaphezu kwemiphumela yawo yokulwa nama-antioxidant, ama-Thearubigins abonise izakhiwo ezinamandla zokulwa nokuvuvukala. Ukuvuvukala okungapheli kuhlotshaniswa nokuguga nezifo ezihlobene nokuguga, futhi ngokunciphisa ukuvuvukala, ama-Thearubigins angadlala indima ebalulekile ekunciphiseni inqubo yokuguga nokunciphisa ingozi yezimo ezifana nesifo senhliziyo, isifo sikashukela, kanye nezinkinga ze-neurodegenerative.
Ngaphezu kwalokho, ama-Thearubigins atholakale enemiphumela emihle empilweni yesikhumba nasekubukekeni. Izifundo zibonise ukuthi ama-Thearubigins angasiza ekuvikeleni isikhumba ekulimaleni okubangelwa yi-UV, anciphise ukubonakala kwemibimbi, futhi athuthukise ukuqina kwesikhumba. Lokhu okutholakele kusikisela ukuthi ama-Thearubigins angaba nomthelela njengesithako semvelo sokulwa nokuguga emikhiqizweni yokunakekelwa kwesikhumba, enikeza enye indlela ephephile nephumelelayo kunezindlela zokwelapha ezivamile zokulwa nokuguga.
Izinzuzo zezempilo ezingaba khona ze-Thearubigins ekulweni nokuguga ziye zavusa isithakazelo ekusetshenzisweni kwazo njengesithasiselo sokudla. Nakuba itiye elimnyama lingumthombo wemvelo we-Thearubigins, ukuhlushwa kwalezi zinhlanganisela kungahluka kuye ngezici ezifana nezindlela zokucubungula itiye kanye namasu okwenza ubhiya. Ngenxa yalokho, kunesithakazelo esikhulayo ekuthuthukisweni kwezithasiselo ze-Thearubigin ezinganikeza umthamo ojwayelekile walezi zinhlanganisela ezinamandla zokulwa nokuguga.
Kubalulekile ukuqaphela ukuthi nakuba ama-Thearubigins ethembisa njengezinto ezilwa nokuguga, kudingeka ucwaningo olwengeziwe ukuze kuqondwe ngokugcwele izindlela zawo zokusebenza kanye nemiphumela emibi engaba khona. Ngaphezu kwalokho, ukutholakala kwe-Thearubigins kanye nesilinganiso sawo esifanele sezinzuzo zokulwa nokuguga kudinga uphenyo olwengeziwe. Noma kunjalo, ubufakazi obandayo obusekela izakhiwo zokulwa nokuguga zama-Thearubigins busikisela ukuthi angaba namandla amakhulu okukhuthaza ukuguga okunempilo nokwandisa isikhathi sokuphila.
Ekuphetheni, ama-Thearubigins (TRs) abonisa imiphumela yokulwa nokuguga ngezakhiwo zawo ezinamandla zokulwa ne-antioxidant, ukulwa nokuvuvukala, kanye nokuvikela isikhumba. Amandla awo okulwa nokucindezeleka kwe-oxidative, ukunciphisa ukuvuvukala, kanye nokuthuthukisa impilo yesikhumba awenza abe yizinto ezithembisayo ekulweni nokuguga kanye nezifo ezihlobene nokuguga. Njengoba ucwaningo kule ndawo luqhubeka nokukhula, ukusetshenziswa okungenzeka kwama-Thearubigins ekukhuthazeni ukuguga okunempilo kanye nokuphila isikhathi eside cishe kuzobonakala kakhulu.
Izinkomba:
Khan N, Mukhtar H. Ama-polyphenol etiye ekukhuthazeni impilo yabantu. Izakhamzimba. 2018;11(1):39.
McKay DL, Blumberg JB. Indima yetiye empilweni yabantu: isibuyekezo. J Am Coll Nutr. 2002;21(1):1-13.
UMandel S, uYoudim MB. Ama-polyphenol e-Catechin: ukonakala kwemizwa kanye nokuvikelwa kwemizwa ezifweni eziwohlokayo zemizwa. I-Free Radic Biol Med. 2004;37(3):304-17.
I-Higdon JV, i-Frei B. Ama-catechin etiye nama-polyphenols: imiphumela yezempilo, i-metabolism, kanye nemisebenzi ye-antioxidant. I-Crit Rev Food Sci Nutr. 2003;43(1):89-143.
Isikhathi sokuthunyelwe: Meyi-10-2024
