I. Isingeniso
Ama-phospholipids ayizingxenye ezibalulekile zolwelwesi lwamaseli futhi adlala indima ebalulekile ekugcineni ubuqotho besakhiwo kanye nokusebenza kwamangqamuzana obuchopho. Zakha i-lipid bilayer ezungeza futhi ivikele ama-neuron namanye amaseli ebuchosheni, okunikela ekusebenzeni okuphelele kwesistimu yezinzwa emaphakathi. Ukwengeza, ama-phospholipids abandakanyeka ezindleleni ezihlukahlukene zokubonisa izimpawu kanye nezinqubo ze-neurotransmission ezibalulekile ekusebenzeni kobuchopho.
Impilo yobuchopho nokusebenza kwengqondo kubalulekile enhlalakahleni yonke kanye nezinga lempilo. Izinqubo zengqondo ezifana nenkumbulo, ukunaka, ukuxazulula izinkinga, nokwenza izinqumo zibalulekile ekusebenzeni kwansuku zonke futhi zincike empilweni nokusebenza kahle kobuchopho. Njengoba abantu bekhula, ukulondoloza ukusebenza kwengqondo kuya ngokuya kubaluleke kakhulu, okwenza ucwaningo lwezinto ezithonya impilo yobuchopho lubaluleke kakhulu ekubhekaneni nokuncipha kwengqondo okuhlobene nobudala kanye nokuphazamiseka kwengqondo okunjengokuwohloka komqondo.
Inhloso yalolu cwaningo ukuhlola nokuhlaziya umthelela we-phospholipid empilweni yobuchopho nokusebenza kwengqondo. Ngokuphenya indima ye-phospholipids ekugcineni impilo yobuchopho kanye nokusekela izinqubo zokuqonda, lolu cwaningo luhlose ukunikeza ukuqonda okujulile kobudlelwane phakathi kwama-phospholipids nokusebenza kobuchopho. Ukwengeza, ucwaningo luzohlola imithelela engaba khona yokungenelela kanye nokwelashwa okuhloswe ngayo ukulondoloza nokuthuthukisa impilo yobuchopho nokusebenza kwengqondo.
II. Ukuqonda ama-Phospholipids
A. Incazelo yama-phospholipids:
Ama-Phospholipidsayisigaba samalipids ayingxenye enkulu yawo wonke ulwelwesi lwamangqamuzana, kuhlanganise nalawo asebuchosheni. Akhiwa i-molecule ye-glycerol, ama-fatty acids amabili, iqembu le-phosphate, neqembu lekhanda le-polar. Ama-phospholipids abonakala ngesimo sawo se-amphiphilic, okusho ukuthi anazo zombili izifunda ze-hydrophilic (eziheha amanzi) kanye ne-hydrophobic (evimbela amanzi). Lesi sakhiwo sivumela ama-phospholipids ukuthi akhe ama-bilayers e-lipid asebenza njengesisekelo sesakhiwo se-membrane yeseli, enikeza umgoqo phakathi kwengaphakathi leseli nendawo yalo yangaphandle.
B. Izinhlobo zama-phospholipids atholakala ebuchosheni:
Ubuchopho buqukethe izinhlobo eziningana ze-phospholipids, enobuningi kakhuluphosphatidylcholinephosphatidylethanolamine,phosphatidylserine, kanye ne-sphingomyelin. Lawa ma-phospholipids afaka isandla ezakhiweni eziyingqayizivele nemisebenzi yamangqamuzana obuchopho. Isibonelo, i-phosphatidylcholine iyingxenye ebalulekile ye-nerve cell membranes, kuyilapho i-phosphatidylserine ihilelekile ekudlulisweni kwesignali nokukhululwa kwe-neurotransmitter. I-Sphingomyelin, enye i-phospholipid ebalulekile etholakala kuzicubu zobuchopho, idlala indima ekugcineni ubuqotho be-myelin sheaths evikela futhi ivikele imicu yezinzwa.
C. Isakhiwo kanye nomsebenzi wama-phospholipids:
Isakhiwo se-phospholipids siqukethe iqembu lekhanda le-hydrophilic phosphate elinamathiselwe ku-molecule ye-glycerol kanye nemisila emibili ye-hydrophobic fatty acid. Lesi sakhiwo se-amphiphilic sivumela ama-phospholipids ukuthi akhe ama-lipid bilayers, amakhanda angama-hydrophilic abheke ngaphandle kanye nemisila ye-hydrophobic ebheke ngaphakathi. Leli lungiselelo lama-phospholipids linikeza isisekelo semodeli ye-mosaic ewuketshezi yolwelwesi lwamaseli, olwenza ukwazi ukukhetha okungenasici okudingekayo ekusebenzeni kwamaselula. Ngokusebenza, ama-phospholipids adlala indima ebalulekile ekugcineni ubuqotho nokusebenza kwamangqamuzana obuchopho. Banikela ekuzinzeni nasekuzinzeni kwamangqamuzana olwelwesi lwamangqamuzana, benze lula ukuthuthwa kwama-molecule kulwelwesi lonke, futhi babambe iqhaza ekuboniseni amaseli nokuxhumana. Ukwengeza, izinhlobo ezithile ze-phospholipids, njenge-phosphatidylserine, ziye zahlotshaniswa nemisebenzi yokuqonda kanye nezinqubo zenkumbulo, ezigqamisa ukubaluleka kwazo empilweni yobuchopho kanye nokusebenza kwengqondo.
III. Umthelela we-Phospholipids Empilweni Yengqondo
A. Ukugcinwa kwesakhiwo seseli yobuchopho:
Ama-phospholipids adlala indima ebalulekile ekugcineni ubuqotho besakhiwo samangqamuzana obuchopho. Njengengxenye enkulu yolwelwesi lwamangqamuzana, ama-phospholipid ahlinzeka ngohlaka oluyisisekelo lokwakheka nokusebenza kwama-neurons namanye amangqamuzana obuchopho. I-phospholipid bilayer yakha umgoqo oguquguqukayo futhi oguquguqukayo ohlukanisa indawo yangaphakathi yamangqamuzana obuchopho endaweni ezungezile yangaphandle, elawula ukungena nokuphuma kwama-molecule nama-ion. Lokhu buqotho besakhiwo kubalulekile ekusebenzeni kahle kwamangqamuzana obuchopho, njengoba kwenza ukugcinwa kwe-homeostasis ye-intracellular, ukuxhumana phakathi kwamaseli, nokudluliswa kwamasignali e-neural.
B. Iqhaza ku-neurotransmission:
Ama-phospholipids aneqhaza elikhulu enqubweni ye-neurotransmission, ebalulekile emisebenzini ehlukahlukene yengqondo njengokufunda, inkumbulo, nokulawulwa kwemizwelo. Ukuxhumana kwemizwa kuncike ekukhululweni, ekusakazweni, nasekutholeni ama-neurotransmitters kuwo wonke ama-synapses, futhi ama-phospholipids abandakanyeka ngokuqondile kulezi zinqubo. Isibonelo, ama-phospholipids asebenza njengezandulela zokuhlanganiswa kwama-neurotransmitters futhi aguqule umsebenzi wama-neurotransmitter receptors kanye nabathuthi. Ama-phospholipids aphinde athinte uketshezi kanye nokungeneka kwamangqamuzana olwelwesi lwamangqamuzana, okuthonya i-exocytosis kanye ne-endocytosis yama-vesicle ane-neurotransmitter kanye nokulawulwa kokudluliswa kwe-synaptic.
C. Ukuvikelwa ekucindezelekeni kwe-oxidative:
Ubuchopho busengozini enkulu yokulimala kwe-oxidative ngenxa yokusebenzisa kakhulu umoya-mpilo, amazinga aphezulu ama-polyunsaturated fatty acids, kanye namazinga aphansi kakhulu ezindlela zokuzivikela ezilwa nokuvuvukala. Ama-phospholipids, njengezakhi eziyinhloko zolwelwesi lwamangqamuzana obuchopho, aneqhaza ekuvikeleni ekucindezelekeni kwe-oxidative ngokusebenza njengezinhloso kanye nama-reservoirs ama-molecule e-antioxidant. Ama-phospholipids aqukethe i-antioxidant compounds, efana ne-vitamin E, adlala indima ebalulekile ekuvikeleni amangqamuzana obuchopho ku-lipid peroxidation nokugcina ubuqotho be-membrane kanye nomswakama. Ngaphezu kwalokho, ama-phospholipids asebenza njengama-molecule ezimpawu ezindleleni zokuphendula zamaselula ezilwa nengcindezi ye-oxidative futhi zikhuthaze ukusinda kwamaseli.
IV. Ithonya le-Phospholipids Kumsebenzi Wokuqonda
A. Incazelo yama-phospholipids:
Ama-phospholipids ayikilasi lama-lipids ayingxenye enkulu yawo wonke ulwelwesi lwamangqamuzana, kuhlanganise nalawo asebuchosheni. Akhiwa i-molecule ye-glycerol, ama-fatty acids amabili, iqembu le-phosphate, neqembu lekhanda le-polar. Ama-phospholipids abonakala ngesimo sawo se-amphiphilic, okusho ukuthi anazo zombili izifunda ze-hydrophilic (eziheha amanzi) kanye ne-hydrophobic (evimbela amanzi). Lesi sakhiwo sivumela ama-phospholipids ukuthi akhe ama-bilayers e-lipid asebenza njengesisekelo sesakhiwo se-membrane yeseli, enikeza umgoqo phakathi kwengaphakathi leseli nendawo yalo yangaphandle.
B. Izinhlobo zama-phospholipids atholakala ebuchosheni:
Ubuchopho buqukethe izinhlobo ezimbalwa ze-phospholipids, eningi kakhulu i-phosphatidylcholine, i-phosphatidylethanolamine, i-phosphatidylserine, ne-sphingomyelin. Lawa ma-phospholipids afaka isandla ezakhiweni eziyingqayizivele nemisebenzi yamangqamuzana obuchopho. Isibonelo, i-phosphatidylcholine iyingxenye ebalulekile ye-nerve cell membranes, kuyilapho i-phosphatidylserine ihilelekile ekudlulisweni kwesignali nokukhululwa kwe-neurotransmitter. I-Sphingomyelin, enye i-phospholipid ebalulekile etholakala kuzicubu zobuchopho, idlala indima ekugcineni ubuqotho be-myelin sheaths evikela futhi ivikele imicu yezinzwa.
C. Isakhiwo kanye nomsebenzi wama-phospholipids:
Isakhiwo se-phospholipids siqukethe iqembu lekhanda le-hydrophilic phosphate elinamathiselwe ku-molecule ye-glycerol kanye nemisila emibili ye-hydrophobic fatty acid. Lesi sakhiwo se-amphiphilic sivumela ama-phospholipids ukuthi akhe ama-lipid bilayers, amakhanda angama-hydrophilic abheke ngaphandle kanye nemisila ye-hydrophobic ebheke ngaphakathi. Leli lungiselelo lama-phospholipids linikeza isisekelo semodeli ye-mosaic ewuketshezi yolwelwesi lwamaseli, olwenza ukwazi ukukhetha okungenasici okudingekayo ekusebenzeni kwamaselula. Ngokusebenza, ama-phospholipids adlala indima ebalulekile ekugcineni ubuqotho nokusebenza kwamangqamuzana obuchopho. Banikela ekuzinzeni nasekuzinzeni kwamangqamuzana olwelwesi lwamangqamuzana, benze lula ukuthuthwa kwama-molecule kulwelwesi lonke, futhi babambe iqhaza ekuboniseni amaseli nokuxhumana. Ukwengeza, izinhlobo ezithile ze-phospholipids, njenge-phosphatidylserine, ziye zahlotshaniswa nemisebenzi yokuqonda kanye nezinqubo zenkumbulo, ezigqamisa ukubaluleka kwazo empilweni yobuchopho kanye nokusebenza kwengqondo.
V. Izinto Ezithinta Amazinga ePhospholipid
A. Imithombo yokudla yama-phospholipids
Ama-phospholipids ayizingxenye ezibalulekile zokudla okunempilo futhi angatholakala emithonjeni ehlukahlukene yokudla. Imithombo eyinhloko yokudla ye-phospholipids ihlanganisa izikhupha zamaqanda, ubhontshisi wesoya, inyama yesitho, nezilwane ezithile zasolwandle ezifana ne-herring, i-mackerel, ne-salmon. Izikhupha zamaqanda, ikakhulukazi, zicebile nge-phosphatidylcholine, enye yama-phospholipids amaningi kakhulu ebuchosheni kanye nesandulela se-neurotransmitter acetylcholine, ebaluleke kakhulu kwinkumbulo nokusebenza kwengqondo. Ukwengeza, ubhontshisi wesoya ungumthombo obalulekile we-phosphatidylserine, enye i-phospholipid ebalulekile enemiphumela enenzuzo ekusebenzeni kwengqondo. Ukuqinisekisa ukudla okunokulinganisela kwale mithombo yokudla kungaba nomthelela ekugcineni amazinga e-phospholipid alungile empilweni yobuchopho nokusebenza kwengqondo.
B. Indlela yokuphila kanye nezici zemvelo
Indlela yokuphila kanye nezici zemvelo zingathinta kakhulu amazinga e-phospholipid emzimbeni. Isibonelo, ukucindezeleka okungapheli kanye nokuchayeka ebuthini bemvelo kungaholela ekwandeni kokukhiqizwa kwama-molecule avuvukalayo athinta ukwakheka nobuqotho bolwelwesi lwamangqamuzana, kuhlanganise nalawo asengqondweni. Ngaphezu kwalokho, izici zendlela yokuphila ezinjengokubhema, ukuphuza ngokweqile, nokudla okunamafutha amaningi kanye namafutha agcwele kungaba nomthelela omubi kumetabolism nokusebenza kwe-phospholipid. Ngokuphambene, ukuvivinya umzimba njalo nokudla okucebile ngama-antioxidants, ama-omega-3 fatty acids, nezinye izakhi ezibalulekile kungakhuthaza amazinga e-phospholipid enempilo futhi kusekele impilo yobuchopho nokusebenza kwengqondo.
C. Amathuba okungezelela
Njengoba kunikezwe ukubaluleka kwama-phospholipid empilweni yobuchopho kanye nokusebenza kwengqondo, kunentshisekelo ekhulayo emandleni e-phospholipid supplementation ukusekela nokwandisa amazinga e-phospholipid. Izithako ze-phospholipid, ikakhulukazi lezo eziqukethe i-phosphatidylserine ne-phosphatidylcholine etholakala emithonjeni efana ne-soy lecithin nama-phospholipids olwandle, ziye zacwaningwa ngemiphumela yazo yokuthuthukisa ingqondo. Izivivinyo zemitholampilo zibonise ukuthi ukwesekwa kwe-phospholipid kungathuthukisa inkumbulo, ukunaka, kanye nesivinini sokucubungula kokubili kubantu abadala nabancane. Ngaphezu kwalokho, izithasiselo ze-phospholipid, uma zihlanganiswa ne-omega-3 fatty acids, zibonise imiphumela ye-synergistic ekukhuthazeni ukuguga kobuchopho obunempilo nokusebenza kwengqondo.
VI. Izifundo zocwaningo kanye nemiphumela
A. Uhlolojikelele Locwaningo Oluhlobene Nge-Phospholipids nempilo Yengqondo
Ama-phospholipids, izakhi eziyinhloko zolwelwesi lwamangqamuzana, adlala indima ebalulekile empilweni yobuchopho nokusebenza kwengqondo. Ucwaningo ngomthelela we-phospholipids empilweni yobuchopho lugxile ezindimeni zabo ku-synaptic plasticity, umsebenzi we-neurotransmitter, kanye nokusebenza kwengqondo okuphelele. Ucwaningo luye lwaphenya imiphumela ye-phospholipids yokudla, njenge-phosphatidylcholine ne-phosphatidylserine, ekusebenzeni kwengqondo kanye nempilo yobuchopho kuzo zombili izinhlobo zezilwane nezihloko zabantu. Ukwengeza, ucwaningo luye lwahlola izinzuzo ezingaba khona ze-phospholipid supplementation ekukhuthazeni ukuthuthukiswa kwengqondo nokusekela ukuguga kobuchopho. Ngaphezu kwalokho, izifundo ze-neuroimaging zinikeze ukuqonda ebudlelwaneni phakathi kwama-phospholipids, ukwakheka kobuchopho, nokuxhumana okusebenzayo, okukhanyisa izindlela eziwumthelela we-phospholipids empilweni yobuchopho.
B. Okutholakele Okubalulekile kanye neziphetho ezivela ezifundweni
Ukuthuthukiswa kwengqondo:Ucwaningo oluningana lubike ukuthi i-phospholipids yokudla, ikakhulukazi i-phosphatidylserine ne-phosphatidylcholine, ingathuthukisa izici ezihlukahlukene zokusebenza kwengqondo, okuhlanganisa inkumbulo, ukunaka, kanye nesivinini sokucubungula. Esivivinyweni somtholampilo esilawulwa ngokungahleliwe, esiyimpumputhe esiphindwe kabili, esilawulwa yi-placebo, i-phosphatidylserine supplementation yatholakala ukuze ithuthukise inkumbulo kanye nezimpawu zokuphazamiseka kokunganakwa kwezingane, okusikisela ukusetshenziswa kokwelapha okungaba khona ukuze kuthuthukiswe ingqondo. Ngokufanayo, izithasiselo ze-phospholipid, lapho zihlanganiswa ne-omega-3 fatty acids, zibonise imiphumela ehambisanayo ekukhuthazeni ukusebenza kwengqondo kubantu abanempilo kuwo wonke amaqembu obudala obuhlukahlukene. Le miphumela igcizelela amandla e-phospholipids njengezithuthukisi zokuqonda.
Ukwakheka Nokusebenza Kobuchopho: Ucwaningo lwe-Neuroimaging lunikeze ubufakazi bokuhlangana phakathi kwe-phospholipids nesakhiwo sobuchopho kanye nokuxhumana okusebenzayo. Isibonelo, ucwaningo lwe-magnetic resonance spectroscopy luveze ukuthi amazinga e-phospholipid ezindaweni ezithile zobuchopho ahlotshaniswa nokusebenza kwengqondo nokuncipha kwengqondo okuhlobene neminyaka. Ukwengeza, ucwaningo lwe-diffusion tensor imaging lubonise umthelela wokubunjwa kwe-phospholipid ekuthembekeni kwezinto ezimhlophe, okubalulekile ekuxhumaneni kwe-neural okuphumelelayo. Lokhu okutholakele kusikisela ukuthi ama-phospholipids adlala indima ebalulekile ekugcineni ukwakheka nokusebenza kobuchopho, ngaleyo ndlela abe nomthelela kumakhono okuqonda.
Imiphumela Yokuguga Kobuchopho:Ucwaningo lwama-phospholipids luphinde lube nomthelela ekugugeni kobuchopho kanye nezimo ze-neurodegenerative. Ucwaningo lubonise ukuthi izinguquko ekubunjweni kwe-phospholipid kanye ne-metabolism kungase kube nomthelela ekwehleni kwengqondo okuhlobene neminyaka kanye nezifo ze-neurodegenerative ezifana nesifo i-Alzheimer's. Ngaphezu kwalokho, i-phospholipid supplementation, ikakhulukazi ngokugxila ku-phosphatidylserine, ibonise isithembiso ekusekeleni ukuguga kobuchopho obunempilo kanye nokunciphisa ukwehla kwengqondo okuhlobene nokuguga. Lokhu okutholakele kugqamisa ukubaluleka kwe-phospholipids kumongo wokuguga kobuchopho kanye nokukhubazeka kwengqondo okuhlobene neminyaka.
VII. Imithelela Yomtholampilo Neziqondiso Zesikhathi esizayo
A. Izinhlelo zokusebenza ezingaba nempilo yobuchopho nokusebenza kwengqondo
Umthelela we-phospholipids empilweni yobuchopho nokusebenza kwengqondo kunemithelela efinyelela kude yezinhlelo zokusebenza ezingaba khona kuzilungiselelo zomtholampilo. Ukuqonda indima ye-phospholipids ekusekeleni impilo yobuchopho kuvula umnyango wokungenelela kwezokwelapha okunoveli kanye namasu okuvimbela okuhloswe ngawo ukuthuthukisa ukusebenza kwengqondo nokunciphisa ukwehla kwengqondo. Izicelo ezingase zibe khona zihlanganisa ukuthuthukiswa kokungenelela kokudla okusekelwe ku-phospholipid, izimiso zokwengeza ezihambisanayo, nezindlela zokwelapha ezihlosiwe zabantu abasengozini yokukhubazeka kwengqondo. Ukwengeza, ukusetshenziswa okungenzeka kokungenelela okusekelwe ku-phospholipid ekusekeleni impilo yobuchopho nokusebenza kwengqondo emitholampilo ehlukahlukene, kuhlanganise nabantu asebekhulile, abantu abanezifo ze-neurodeergenerative, nalabo abanokukhubazeka kwengqondo, kunesithembiso sokuthuthukisa imiphumela yonke yokucabanga.
B. Ukucatshangelwa kocwaningo olwengeziwe nezivivinyo zomtholampilo
Ucwaningo olwengeziwe nezivivinyo zomtholampilo zibalulekile ukuze sithuthukise ukuqonda kwethu umthelela we-phospholipids empilweni yobuchopho nokusebenza kwengqondo kanye nokuhumusha ulwazi olukhona lube ukungenelela komtholampilo okuphumelelayo. Ucwaningo lwesikhathi esizayo kufanele luhlose ukucacisa izindlela ezingaphansi kwemiphumela ye-phospholipids empilweni yobuchopho, kuhlanganise nokusebenzisana kwabo nezinhlelo ze-neurotransmitter, izindlela zokubonisa amaselula, kanye nezindlela ze-neural plasticity. Ngaphezu kwalokho, ukuhlolwa kwemitholampilo yesikhathi eside kuyadingeka ukuze kuhlolwe imiphumela yesikhathi eside yokungenelela kwe-phospholipid ekusebenzeni kwengqondo, ukuguga kobuchopho, kanye nengozi yezimo ze-neurodegenerative. Ukucatshangelwa kocwaningo olwengeziwe kuhlanganisa nokuhlola imiphumela engaba khona ye-synergistic ye-phospholipids nezinye izinhlanganisela ze-bioactive, njengama-omega-3 fatty acids, ekuthuthukiseni impilo yobuchopho nokusebenza kwengqondo. Ukwengeza, izivivinyo zomtholampilo ezihlukanisiwe ezigxile emiphakathini ethile yeziguli, njengabantu ngabanye abasezigabeni ezihlukene zokukhubazeka kwengqondo, zinganikeza imininingwane ebalulekile ekusetshenzisweni okuhambisanayo kokungenelela kwe-phospholipid.
C. Imithelela empilweni nasemfundweni yomphakathi
Imithelela ye-phospholipids empilweni yobuchopho nokusebenza kwengqondo idlulela empilweni yomphakathi kanye nemfundo, nemithelela engaba khona kumasu okuvimbela, izinqubomgomo zezempilo zomphakathi, nezinhlelo zemfundo. Ukusatshalaliswa kolwazi mayelana nendima ye-phospholipids empilweni yobuchopho nokusebenza kwengqondo kungazisa imikhankaso yezempilo yomphakathi ehloselwe ukukhuthaza imikhuba yokudla enempilo esekela ukudla okwanele kwe-phospholipid. Ngaphezu kwalokho, izinhlelo zemfundo ezibhekiswe kubantu abahlukahlukene, okuhlanganisa abantu abadala asebekhulile, abanakekeli, nabasebenzi bezempilo, zingaqwashisa ngokubaluleka kwama-phospholipids ekugcineni ukuqina kwengqondo nokunciphisa ingozi yokuncipha kwengqondo. Ngaphezu kwalokho, ukuhlanganiswa kolwazi olusekelwe ebufakazini kuma-phospholipids kukharikhulamu yezemfundo yabasebenzi bezokunakekelwa kwempilo, izazi zokudla okunomsoco, kanye nothisha kungathuthukisa ukuqonda kwendima yokudla okunomsoco empilweni yengqondo futhi kunikeze abantu amandla okwenza izinqumo ezinolwazi mayelana nempilo yabo yengqondo.
VIII. Isiphetho
Kukho konke lokhu kuhlolwa komthelela we-phospholipids empilweni yobuchopho kanye nokusebenza kwengqondo, amaphuzu amaningana abalulekile avele. Okokuqala, ama-phospholipids, njengezingxenye ezibalulekile zolwelwesi lwamangqamuzana, adlala indima ebalulekile ekugcineni ubuqotho besakhiwo nokusebenza kobuchopho. Okwesibili, ama-phospholipids anomthelela ekusebenzeni kwengqondo ngokusekela i-neurotransmission, i-synaptic plasticity, kanye nempilo yonke yobuchopho. Ngaphezu kwalokho, ama-phospholipids, ikakhulukazi lawo acebile ku-polyunsaturated fatty acids, ahlotshaniswa nemiphumela ye-neuroprotective kanye nezinzuzo ezingaba khona ekusebenzeni kwengqondo. Ukwengeza, izici zokudla nendlela yokuphila ezithonya ukwakheka kwe-phospholipid zingathinta impilo yobuchopho nokusebenza kwengqondo. Okokugcina, ukuqonda umthelela we-phospholipids empilweni yobuchopho kubalulekile ekuthuthukiseni ukungenelela okuhlosiwe ukukhuthaza ukuqina kwengqondo nokunciphisa ingozi yokuncipha kwengqondo.
Ukuqonda umthelela we-phospholipids empilweni yobuchopho kanye nokusebenza kwengqondo kubaluleke kakhulu ngezizathu ezimbalwa. Okokuqala, ukuqonda okunjalo kunikeza ukuqonda ezinkambisweni eziyisisekelo somsebenzi wokuqonda, okunikeza amathuba okuthuthukisa ukungenelela okuhlosiwe ukusekela impilo yobuchopho nokuthuthukisa ukusebenza kwengqondo kuyo yonke iminyaka yokuphila. Okwesibili, njengoba iminyaka yabantu emhlabeni wonke kanye nokusabalala kokuncipha kwengqondo okuhlobene neminyaka kukhuphuka, ukucacisa indima ye-phospholipids ekugugeni kwengqondo kuya ngokuya kubaluleka ekukhuthazeni ukuguga okunempilo kanye nokugcina ukusebenza kwengqondo. Okwesithathu, ukuguqulwa okungaba khona kokubunjwa kwe-phospholipid ngokusebenzisa ukungenelela kokudla kanye nendlela yokuphila kugcizelela ukubaluleka kokuqwashisa kanye nemfundo mayelana nemithombo kanye nezinzuzo zama-phospholipids ekusekeleni umsebenzi wokuqonda. Ngaphezu kwalokho, ukuqonda umthelela we-phospholipids empilweni yobuchopho kubalulekile ekwaziseni amasu ezempilo yomphakathi, ukungenelela komtholampilo, nezindlela eziqondene nomuntu ezihloselwe ukukhuthaza ukuqina kwengqondo kanye nokunciphisa ukwehla kwengqondo.
Sengiphetha, umthelela we-phospholipids empilweni yobuchopho kanye nokusebenza kwengqondo kuyindawo yocwaningo enezici eziningi futhi eguquguqukayo enemithelela ebalulekile empilweni yomphakathi, umkhuba womtholampilo, kanye nenhlalakahle yomuntu ngamunye. Njengoba ukuqonda kwethu indima yama-phospholipids ekusebenzeni kwengqondo kuqhubeka nokuvela, kubalulekile ukuqaphela amandla okungenelela okuhlosiwe kanye namasu omuntu siqu asebenzisa izinzuzo ze-phospholipids ukuze kuthuthukiswe ukuqina kwengqondo kuyo yonke iminyaka yokuphila. Ngokuhlanganisa lolu lwazi ezinhlelweni zezempilo zomphakathi, umkhuba wokwelapha, kanye nemfundo, singanika abantu amandla okwenza izinqumo ezinolwazi ezisekela impilo yobuchopho nokusebenza kwengqondo. Ekugcineni, ukugqugquzela ukuqonda okuphelele komthelela we-phospholipids empilweni yobuchopho nokusebenza kwengqondo kunesithembiso sokuthuthukisa imiphumela yengqondo nokukhuthaza ukuguga okunempilo.
Ireferensi:
1. Alberts, B., et al. (2002). I-Molecular Biology yeseli (4th ed.). ENew York, NY: Garland Science.
2. Vance, JE, & Vance, DE (2008). I-Phospholipid biosynthesis kumaseli ezincelisayo. I-Biochemistry kanye ne-Cell Biology, 86(2), 129-145. https://doi.org/10.1139/O07-167
3. Svennerholm, L., & Vanier, MT (1973). Ukusatshalaliswa kwe-lipids ohlelweni lwezinzwa lomuntu. II. Ukwakheka kwe-lipid yobuchopho bomuntu ngokuhlobene neminyaka, ubulili, kanye nesifunda se-anatomical. Ubuchopho, 96(4), 595-628. https://doi.org/10.1093/brain/96.4.595
4. U-Agnati, LF, & Fuxe, K. (2000). Ukudluliswa kwevolumu njengesici esiyinhloko sokuphathwa kolwazi ohlelweni lwezinzwa olumaphakathi. Inani elisha lokuhumusha elingaba khona lomshini wohlobo lwe-B we-Turing. Inqubekelaphambili Ocwaningweni Lobuchopho, 125, 3-19. https://doi.org/10.1016/S0079-6123(00)25003-X
5. Di Paolo, G., & De Camilli, P. (2006). I-Phosphoinositides ku-cell regulation kanye ne-membrane dynamics. Imvelo, 443(7112), 651-657. https://doi.org/10.1038/nature05185
6. Markesbery, WR, & Lovell, MA (2007). Ukulimala kwe-lipids, amaprotheni, i-DNA, ne-RNA ekukhubazekeni kwengqondo okuncane. Izingobo zomlando ze-Neurology, 64(7), 954-956. https://doi.org/10.1001/archneur.64.7.954
7. I-Bazinet, RP, & Layé, S. (2014). Amafutha e-Polyunsaturated fatty acids nama-metabolites awo ekusebenzeni kobuchopho nezifo. Ukubuyekezwa Kwemvelo I-Neuroscience, i-15 (12), i-771-785. https://doi.org/10.1038/nrn3820
8. Jäger, R., Purpura, M., Geiss, KR, Weiß, M., Baumeister, J., Amatulli, F., & Kreider, RB (2007). Umphumela we-phosphatidylserine ekusebenzeni kwegalofu. Ijenali ye-International Society of Sports Nutrition, 4(1), 23. https://doi.org/10.1186/1550-2783-4-23
9. Cansev, M. (2012). Amafutha acid abalulekile kanye nobuchopho: Imithelela yezempilo engaba khona. I-International Journal ye-Neuroscience, i-116 (7), i-921-945. https://doi.org/10.3109/00207454.2006.356874
10. Kidd, PM (2007). I-Omega-3 DHA kanye ne-EPA yokuqaphela, ukuziphatha, kanye nesimo sengqondo: okutholwe emitholampilo kanye nokusebenzelana kwesakhiwo ne-cell membrane phospholipids. Ukubuyekezwa Kwemithi Ehlukile, 12(3), 207-227.
11. Lukiw, WJ, & Bazan, NG (2008). I-Docosahexaenoic acid kanye nobuchopho obuguga. Ijenali Yezokudla, 138(12), 2510-2514. https://doi.org/10.3945/jn.108.100354
12. Hirayama, S., Terasawa, K., Rabeler, R., Hirayama, T., Inoue, T., & Tatsumi, Y. (2006). Umthelela wokuphathwa kwe-phosphatidylserine enkumbulo kanye nezimpawu ze-attention-deficit hyperactivity disorder: Isivivinyo somtholampilo esilawulwa ngokungahleliwe, esingaboni kabili, esilawulwa yi-placebo. Ijenali Yokudla Kwabantu Nezokudla, 19(2), 111-119. https://doi.org/10.1111/j.1365-277X.2006.00610.x
13. Hirayama, S., Terasawa, K., Rabeler, R., Hirayama, T., Inoue, T., & Tatsumi, Y. (2006). Umthelela wokuphathwa kwe-phosphatidylserine enkumbulo kanye nezimpawu ze-attention-deficit hyperactivity disorder: Isivivinyo somtholampilo esilawulwa ngokungahleliwe, esingaboni kabili, esilawulwa yi-placebo. Ijenali Yokudla Kwabantu Nezokudla, 19(2), 111-119. https://doi.org/10.1111/j.1365-277X.2006.00610.x
14. Kidd, PM (2007). I-Omega-3 DHA kanye ne-EPA yokuqaphela, ukuziphatha, kanye nesimo sengqondo: okutholwe emitholampilo kanye nokusebenzelana kwesakhiwo ne-cell membrane phospholipids. Ukubuyekezwa Kwemithi Ehlukile, 12(3), 207-227.
15. Lukiw, WJ, & Bazan, NG (2008). I-Docosahexaenoic acid kanye nobuchopho obuguga. Ijenali Yezokudla, 138(12), 2510-2514. https://doi.org/10.3945/jn.108.100354
16. Cederholm, T., Salem, N., Palmblad, J. (2013). ω-3 Fatty acids ekuvimbeleni ukwehla kwengqondo kubantu. Intuthuko kwezokudla, 4(6), 672-676. https://doi.org/10.3945/an.113.004556
17. Fabelo, N., Martín, V., Santpere, G., Marín, R., Torrent, L., Ferrer, I., Díaz, M. (2011). Ushintsho olukhulu ekubunjweni kwe-lipid ye-frontal cortex lipid rafts kusukela ku-Parkinson's disease kanye nengozi 18. Isifo sika-Parkinson. Umuthi wamangqamuzana, 17(9-10), 1107-1118. https://doi.org/10.2119/molmed.2011.00137
19. Kanoski, SE, and Davidson, TL (2010). Amaphethini ahlukene okukhubazeka kwenkumbulo ahambisana nokugcinwa kwesikhashana kanye nesikhathi eside ekudleni okunamandla amakhulu. Ijenali ye-Experimental Psychology: Izinqubo Zokuziphatha Kwezilwane, 36(2), 313-319. https://doi.org/10.1037/a0017318
Isikhathi sokuthumela: Dec-26-2023
