Izindaba - Lokho Iqabunga Le-Antioxidant-Ginkgo Leaf lemvelo!

I. Isingeniso

Ukuqalisa

Yiziphi izinzuzo zezempilo ze-Ginkgo Biloba Extract Powder (2)

Ukukhishwa Kweqabunga le-GinkGoIngabe into esebenzayo yemvelo ekhishwe amaqabunga e-ginkgo. Izakhi zayo eziphambili ngama-flavonoroids nama-ginkgo lactones. I-PAF ethile (i-Platelet-activation factor, i-Platelet-active factor) i-receptor anaging. Imisebenzi yayo yecala ifaka phakathi: Ukuthuthukisa ukusakazwa kwe-cerebral kanye ne-cell metabolism; Ukwanda komsebenzi we-Red Perce Cell Superoxide Dismutase (Sod) kanye ne-Glutathione Peroxidase (GSH-PX), kanye nokunciphisa i-membrane membrane i-lipids (MDA). ukukhiqizwa, ama-scavenge ama-radicals wamahhala, ukuvimbela ukulimala kwamakhambi e-cardiomyocytes namaseli we-vascur endothelial; Khetha ukukhetha ukuhlanganisa ukuhlanganiswa kwe-platelet, i-thrombosis encane, kanye nokuphazamiseka kwe-metabolism ye-lipid okubangelwa yiPlatelet PAF; Thuthukisa ukujikeleza kwenhliziyo ye-coronary yenhliziyo futhi kuvikele i-Ischemic myocardium; Khuphula amandla okuwohloka kwamangqamuzana abomvu egazi, anciphise ukuvuleka kwegazi, futhi aqede ukuphazamiseka kwe-microcirngotory; Vimba ukuhlanganiswa kwe-Thromboxboxane (TXA2) futhi uvuse ukukhishwa kwe-Prostaglandin PGI2 kusuka kumaseli we-vascular endothelial.

Umthombo wesitshalo

I-GinkGo Biloba yiqabunga le-Ginkgo Biloba L., isitshalo somndeni we-Ginkgo. Ukukhishwa kwayo (i-EGB) inemisebenzi ehlukahlukene yezempilo futhi isetshenziswa kabanzi ekudleni nasezimophini. Ukwakhiwa kwamakhemikhali ama-Ginkgo amaqabunga kuyinkimbinkimbi kakhulu, ngamakhompiyutha angaphezu kuka-140 ahlukaniswe kuwo. Ama-Flavonoids nama-terpene lactones yizithako ezimbili eziphambili ezisebenzayo zamaqabunga e-ginkgo. Ngaphezu kwalokho, futhi iqukethe i-polyprenol, ama-organic acid, ama-polysaccharides, ama-amino acid, ama-phenols kanye nezinto ezilandelwayo. Ngokusho kwezibalo ezingaphelele, ukukhishwa kwamanje kwamaqabunga ajwayelekile e-GinkGo Leaf yi-EGB761 ekhiqizwa ngokusho kwenqubo ye-Schane's Patent Potent. Kuvela njengempuphu ensundu futhi inephunga elincane leqabunga le-GinkGo. Ukwakheka kwamakhemikhali kungama-24% ama-flavonoid, ama-6% terpene lactones, ngaphansi kwe-7.0% proanthocyanidins, ama-glycososis ayi-13.0%, ama-20% ama-flavonoid glycosides, kanye nama-polymer ahlanganisiwe. I-%, I-INorganic Faceboc 5.0%, umswakama u-solvent 3.0%, abanye 3.0%.

Izici ze-antioxidant kanye nendlela

Ukukhishwa kweqabunga le-GinkGo kungasusa ngqo ama-radicals wamahhala we-lipid, i-lipid peroxidation yamahhala yama-radicals alkane ama-radicals, njll. Ngasikhathi sinye, futhi singalawula futhi sithuthukise umsebenzi wama-enzyme antioxidant afana ne-superoxide dismutase kanye ne-glutathione peroxidase. Umphumela we-antioxidant wama-flavonoids ku-EGB weqa leyo yamavithamini, futhi unezakhiwo ezihlasela ezingenakulwa ne-anti-free radical attack eVitro.

Imiphumela ye-antioxidant ye-Ginkgo ekhishwe izindlela ezahlukahlukene ihlukile, futhi imiphumela ye-antioxidant yokukhishwa okungcolile nemikhiqizo ecwengekile nayo ihlukile. Ma Xhan et al. Uthole ukuthi i-petroleum ether-ethanol ekhipha i-antioxidant inomphumela oqinile we-antioxidant kumafutha okudlwengulwa uma kuqhathaniswa namaqabunga e-GinkGo Leaf atholwe ngezindlela ezahlukahlukene zokulungiselela. Umthamo we-antioxidant we-crude ginkgo leaf extract ephakeme kancane kunaleso sokukhishwa okucwengekile. Lokhu kungahle kube khona ngenxa yokwakhi okukhishwe kuqukethe ezinye izithako ze-antioxidant, ezifana nama-organic acid, ama-amino acid, ama-tannins, ama-alkalo, nezinye izinto ezinemiphumela ye-synergistic.

Indlela yokulungiselela

. Njengoba amanye ama-solvents aphilayo anobuthi noma aguquguqukayo, i-ethanol ngokuvamile isetshenziswa njenge-ejenti yokukhishwa. Ukuhlolwa kukaZhang Yonghong kanti abanye bakhombisa ukuthi izimo ezinhle kakhulu zokukhipha ama-flavonoid avela kuma-ginkgo amaqabunga njengekhambi le-90% C, isilinganiso sokukhishwa kungu-1: 20, isikhathi ngasinye sibonisa amahora angama-1.5.

. Ngakho-ke, ukukhishwa kwe-ultrasonic kwama-flavonoids kunezinzuzo ezinhle. Imiphumela yokuhlola etholwe nguLiu jingzhi et al. Khombisa ukuthi izimo zenqubo zokukhishwa kwe-ultrasonic yilezi: Imvamisa ye-ultrasonic 40Khz, isikhathi sokwelashwa se-ultrasonic, izinga lokushisa 35min, lokuma kwe-3H. Ngalesi sikhathi, isilinganiso sokukhishwa singama-81.9%.

Isicelo

Ama-flavonoids kuma-ginkgo anamaqabunga anezakhiwo ze-antioxidant futhi angangezwa kumafutha namakhekhe njenge-antioxidants. Ama-flavonoid aphelele aphuzi kakhulu futhi abe ne-soubity ebanzi, womabili amanzi ancibilikayo futhi anamafutha, ngakho-ke ama-flavonoid aphelele angasetshenziselwa ukufakwa imibala. umphumela we-agent. UGinkgo Biloba ucutshungulwa empuphu ye-ultrafine futhi wengezwa ekudleni. Amaqabunga e-Ginkgo awohloka kahle futhi angezwe kumaqebelengwane, amabhisikidi, ama-noodle, amaswidi, kanye no-ayisikhilimu ngesilinganiso se-5% kuya ku-10% ukuwacubungula ekudleni kwamaqabunga e-GinkGo ngemiphumela yokunakekelwa kwempilo.
I-GinkGo Leaf Extract isetshenziswa njengesengezo sokudla eCanada futhi ivunyelwe njengezidakamizwa ezingaphezu kwe-gerany eJalimane naseFrance. I-GinkGo Leaf ifakiwe e-United States pharmacopoeia (i-24th edition) futhi ingasetshenziswa njengesengezo sokudla e-United States.

Imiphumela yekhemisi

1. Umphumela ohlelweni lwenhliziyo
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. Ingavimbela ukungasebenzi kwenhliziyo okubangelwa ukuwohloka kwenhliziyo kuzingulube eziqhelile ze-Guinea.
. Ukukhishwa kweqabunga le-GinkGo kungavimba ukwanda kobubanzi be-mesenteric microvascular ububanzi obubangelwa yi-endotoxin ye-intravenous. Emodeli yeCanine endotoxin, i-GinkGo Biloba ekhipha izinguquko ze-hemodynamic; Emodelikweni yamaphaphu yezimvu, i-GinkGo Biloba ekhipha i-hypertension ye-hypertension ne-pulmonary edema ebangelwa ukuphazamiseka kwe-lymphatic okubangelwa yi-endotoxin.
. Ngemuva kwezinsuku ezingama-40, okuqukethwe kwe-serum triglyceride kwancishiswa kakhulu. I-GinkGo Biloba ekhipha (i-20 mg / kg ngosuku) ilawulwa ngomlomo onogwaja ethola ukudla okujwayelekile nokuhlanzekile. Ngemuva kwenyanga eyodwa, amazinga we-cholesterol achazwe nge-hyper ku-plasma kanye ne-aorta yomvundla abathola ukudla kwe-atherogenic babencishiswa kakhulu. Noma kunjalo amazinga we-cholesterol wamahhala ahlala engashintshiwe.
(5) UGinkgo Terpene Lactone ungumbhalo okhethekile we-paf receptor. I-GinkGo Leaf Extract noma i-GinkGo Terpene Lactone ingavimbela i-Platelet-activation Factor (PAF) ne-cyclooxygenase noma i-lipoxygenase. Ukukhishwa kweqabunga le-GinkGo bekubekezelelwa kahle futhi okuhlanganisiwe kwePlatethalolet okubangelwa yi-PAF kepha akuzange kuthintiwe ukuhlanganiswa okubangelwa i-ADP.

2. Umphumela ohlelweni lwezinzwa oluphakathi
(1) Ukukhishwa kweqabunga le-GinkGo kuthinta uhlelo lwe-endocrine kanye nokuxhumana phakathi kwamasosha omzimba kanye nohlelo oluphakathi lwezinzwa ngokuvimbela isenzo se-PAF. Kungathuthukisa i-metabolism yokujikeleza ubuchopho futhi kuthuthukiswe umsebenzi wememori.
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. kuthuthukisa umsebenzi wezinja ngemuva kokuthola ukulungiswa kwe-neuronal kokuqala kwe-neuronal kanye nokuncishiswa komonakalo we-neuronal kulandela i-ischemia eHippocampus yeBerbil Brain; Yehlisa kakhulu ukulahleka kwe-ATP, amp, e-Creatine ne-Creatine kanye ne-Creatine Phosphate ku-Ischecmic Frasis yenja ye-mongrel. UGinkgo Biloba Lactone B uyasebenziseka ekwelashweni komtholampilo unhlangothi.

3. Umphumela ohlelweni lokugaya ukudla
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. Lokhu kukhombisa ukuthi ukukhishwa kweqabunga le-GinkGo kunethonya lezokwelapha elingaba khona ku-Cirrhosis yesibindi. Kungavimba ukwakheka kwama-radicals angenama-oksijini e-mouse acute pancreatitis okubangelwa cholecystokinin. UGinkgo Terpene Lactone B angaba neqhaza ekwelapheni i-pancreatitis ebukhali.

4. Umphumela ohlelweni lokuphefumula
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. Ukukhishwa kweqabunga le-GinkGo kubaluleke kakhulu ekuvimbeleni nasekuphatheni nge-bronchial hyperronsiveness.

I-5. Ukulwa nokuguga
Ginkgobiflavoroids, isoginkgobiflavoroids, i-Ginkgo Biloba, ne-Qucetin eGinkgo ishiya konke kuvimbela i-lipid peroxidation, ikakhulukazi njengoba i-qurcetin inomsebenzi oshubile. Izivivinyo zenziwa ngamagundane futhi kwatholakala ukuthi ama-GinkGo Leaf amaqabunga akhishwe ngamanzi (0.95mg / ML) anganciphisa kakhulu ama-perconoids we-reemur, i-acink sod yomsebenzi angakhuphula amandla okuvunywa kwegazi ngenkathi enciphisa umsebenzi we-sgpt ngenkathi enciphisa umsebenzi we-sgpt.

7. Indima ekwenqatshelweni kwe-Fenklant nokunye ukuphendula okungasebenzi
Ukukhishwa kweqabunga le-GinkGo kunganweba isikhathi sokusinda se-Skin Graffs, i-heterotopic inhliziyo Xenograft, kanye ne-Orthotopic Light Xenograft. Ukukhishwa kweqabunga le-GinkGo kungavimba umsebenzi wezeseli wemvelo wemvelo wokubulala umzimba ngokumelene namaseli wethagethi ye-KC526, futhi kungavimba futhi umsebenzi weseli wemvelo owenziwe nge-interferon.

8. Umphumela we-Anti-Stamsur
Ukukhishwa okukhishwe kwamaqabunga aluhlaza we-ginkgo biloba, ingxenye enamafutha, ingavimba igciwane le-epstein -br. I-Heptadecene Salicylic acid kanye neBilo-Betin inomsebenzi oqinile wokuvimbela; Ama-flavonoid aphelele e-ginkgo angakhuphula isisindo se-thymus samagundane athela isimilala. kanye namazinga omsebenzi we-sod, ahlanganisa ikhono lomzimba lemvelo le-anti-tum; I-QeceCetin ne-Myrierrietitin ingavimbela ukwenzeka kwama-carcinogens.

Amanothi kanye nokuphikisana

Ukuphendula okunamandla kwe-GinkGo Leaf Extract: Ngesinye isikhathi ukungakhululeki kwamathumbu, njenge-anorexia, isicanucanu, ukuqunjelwa, ukubhekana nezitofu ezikhululekile, njll.; Kungahle kube nokunyuka kwesilinganiso senhliziyo, ukukhathala, njll., Kepha lokhu akuthinti ekwelashweni. Ngemuva kokuphathwa komlomo kwesikhathi eside, izinkomba ezifanele ze-Rhelogy yegazi kufanele zibuyekezwe njalo. Uma unezimpawu zesisu, ungayithatha ngemuva kokudla esikhundleni salokho.

Ukusebenzisana kwezidakamizwa

Lo mkhiqizo unomphumela we-synergistic uma usetshenziswa ngokuhambisana nokunye okubonakalayo okwehlisa izidakamizwa, njenge-sodium alginate diester, i-acetate, njll., Okungathuthukisa ukusebenza kahle.

Isimo sokuthuthuka

Amaqabunga e-ginkgo aqukethe inani elincane lama-proanthocyanidins nama-acid e-urushiolic, asanobuthi emzimbeni womuntu. Lapho i-Ginkgo ishiya njengezinto ezingavuthiwe ukucubungula ukudla, ukwelashwa okukhethekile kuyadingeka ukunciphisa okuqukethwe kwama-proanthocyanidins nama-acid e-urushiolic. Kodwa-ke, ngaphakathi kwebanga ledosi elisetshenzisiwe njengamanje, akukho ubuthi obukhulu noma obungapheli futhi akukho miphumela ye-teratogenic. UMnyango Wezempilo uvumile uGinkgo Biloba ukhiphe njengesengezo sokudla esisha ngo-1992. Eminyakeni yamuva nje, i-GinkGo Biloba I-Flavonoids isetshenziswe kabanzi embonini yokudla, nocwaningo kanye nokwakhiwa kukaGinkgo Biloba kunamathemba abanzi.