Isingeniso
Ama-Ginsenosideskuyisigaba samakhemikhali emvelo atholakala ezimpandeni zesitshalo se-Panax ginseng, esisetshenziswe amakhulu eminyaka kwezokwelapha zendabuko zaseShayina. Lawa makhemikhali asebenzayo athole ukunakwa okukhulu eminyakeni yamuva ngenxa yezinzuzo zawo zezempilo ezingaba khona. Kulesi sihloko, sizohlola izinzuzo ezahlukahlukene zama-ginsenosides, okuhlanganisa nemiphumela yawo ekusebenzeni kwengqondo, ukuguqulwa kwesistimu yomzimba, izakhiwo zokulwa nokuvuvukala, kanye nomsebenzi ongaba khona wokulwa nomdlavuza.
Umsebenzi Wokuqonda
Enye yezinzuzo ezaziwa kakhulu zama-ginsenosides ukuthi angakwazi ukuthuthukisa ukusebenza kwengqondo. Izifundo eziningana zibonise ukuthi ama-ginsenosides angathuthukisa inkumbulo, ukufunda, kanye nokusebenza kwengqondo okuphelele. Le miphumela kucatshangwa ukuthi ibangelwa izindlela ezahlukene, okuhlanganisa ukuguqulwa kwama-neurotransmitter, njenge-acetylcholine ne-dopamine, kanye nokukhuthazwa kwe-neurogenesis, inqubo yokukhiqiza ama-neurons amasha ebuchosheni.
Ocwaningweni olwanyatheliswa kuyi-Journal of Ethnopharmacology, abacwaningi bathole ukuthi ama-ginsenoside angathuthukisa ukufunda kwendawo kanye nenkumbulo kumagundane ngokuthuthukisa ukubonakaliswa kwe-neurotrophic factor (BDNF) etholakala ebuchosheni, iphrotheni esekela ukusinda nokukhula kwama-neurons. Ngaphezu kwalokho, ama-ginsenoside aboniswe ukuthi avikela ekuwohlokeni kwengqondo okuhlobene nokuguga kanye nezifo ze-neurodegenerative, njengesifo i-Alzheimer's kanye ne-Parkinson's, ngokunciphisa ukucindezeleka kwe-oxidative kanye nokuvuvukala ebuchosheni.
Ukuguqulwa Kwesistimu Yokuzivikela Emzimbeni
Ama-ginsenosides atholakale futhi eguqula isimiso somzimba sokuzivikela, athuthukise ikhono laso lokuzivikela ezifweni nasezifweni. Lawa ma-compounds aboniswe ukuthi akhuthaza ukukhiqizwa kanye nomsebenzi wamaseli ahlukahlukene omzimba, njengamaseli okubulala emvelo, ama-macrophage, nama-T lymphocyte, adlala indima ebalulekile ekuvikeleni komzimba ezifweni ezibangelwa amagciwane kanye namaseli omdlavuza.
Ucwaningo olushicilelwe kumagazini i-International Immunopharmacology lubonise ukuthi ama-ginsenoside angathuthukisa impendulo yomzimba emagundwini ngokwandisa ukukhiqizwa kwama-cytokine, okuyizimpawu zama-molecule alawula ukusebenza kwamaseli omzimba. Ngaphezu kwalokho, ama-ginsenoside aboniswe ukuthi anezakhiwo zokulwa namagciwane kanye nezokulwa namagciwane, okwenza abe ikhambi lemvelo elithembisayo lokusekela impilo yomzimba kanye nokuvimbela ukutheleleka.
Izakhiwo Ezilwa Nokuvuvukala
Ukuvuvukala kuyindlela yemvelo yokusabela kwesimiso somzimba sokuzivikela ekulimaleni nasekuthelelekeni, kodwa ukuvuvukala okungapheli kungasiza ekuthuthukisweni kwezifo ezahlukahlukene, okuhlanganisa isifo senhliziyo, isifo sikashukela, kanye nomdlavuza. Ama-ginsenoside atholakale enezakhiwo ezinamandla zokulwa nokuvuvukala, ezingasiza ekunciphiseni imiphumela elimazayo yokuvuvukala okungapheli emzimbeni.
Ucwaningo olushicilelwe ku-Journal of Ginseng Research lubonise ukuthi ama-ginsenoside angavimbela ukukhiqizwa kwama-cytokine abangela ukuvuvukala futhi avimbele ukusebenza kwezindlela zokubonisa ukuvuvukala emaseli omzimba. Ngaphezu kwalokho, ama-ginsenoside aboniswe ukuthi anciphisa ukubonakaliswa kwezindlela zokuvuvukala, njenge-cyclooxygenase-2 (COX-2) kanye ne-inducible nitric oxide synthase (iNOS), ezihilelekile empendulweni yokuvuvukala.
Umsebenzi Wokulwa Nomdlavuza
Esinye isici esithakazelisayo ocwaningweni lwe-ginsenoside umsebenzi wazo ongaba khona wokulwa nomdlavuza. Izifundo eziningana ziphakamise ukuthi ama-ginsenoside angase abe nemiphumela yokulwa nomdlavuza ngokuvimbela ukukhula nokwanda kwamaseli omdlavuza, okubangela i-apoptosis (ukufa kwamaseli okuhleliwe), kanye nokucindezela i-angiogenesis yesimila (ukwakheka kwemithambo yegazi emisha ukusekela ukukhula kwesimila).
Ukubuyekezwa okwanyatheliswa kuyi-International Journal of Molecular Sciences kugcizelele amandla okulwa nomdlavuza we-ginsenosides, ikakhulukazi kumdlavuza webele, wamaphaphu, wesibindi kanye nowe-colorectal. Ukubuyekezwa kuxoxisane ngezindlela ezahlukene ama-ginsenosides asebenzisa ngazo imiphumela yawo yokulwa nomdlavuza, okuhlanganisa ukuguqulwa kwezindlela zokubonisana kwamaseli, ukulawulwa kokuqhubeka komjikelezo weseli, kanye nokuthuthukiswa kwempendulo yomzimba ngokumelene namaseli omdlavuza.
Isiphetho
Ekuphetheni, ama-ginsenosides ayizakhi eziphilayo ezitholakala ku-Panax ginseng ezinikeza izinzuzo eziningi ezingaba khona zempilo. Lokhu kufaka phakathi ukuthuthukiswa kokusebenza kwengqondo, ukuguqulwa kwesimiso somzimba sokuzivikela, izakhiwo zokulwa nokuvuvukala, kanye nomsebenzi ongase ube khona wokulwa nomdlavuza. Nakuba kudingeka ucwaningo olwengeziwe ukuze kuqondwe ngokugcwele izindlela zokusebenza kanye namandla okwelapha ama-ginsenosides, ubufakazi obukhona busikisela ukuthi lawa mazakhi athembisa njengemithi yemvelo yokukhuthaza impilo kanye nenhlalakahle iyonke.
Izinkomba
UKim, JH, kanye no-Yi, YS (2013). I-Ginsenoside Rg1 icindezela ukusebenza kwamaseli e-dendritic kanye nokwanda kwamaseli e-T ngaphakathi kwe-vitro kanye nangaphakathi kwe-vivo. I-International Immunopharmacology, 17(3), 355-362.
ULeung, KW, & Wong, AS (2010). I-Pharmacology ye-ginsenosides: isibuyekezo sezincwadi. Imithi YaseShayina, 5(1), 20.
Radad, K., Gille, G., Liu, L., Rausch, WD, kanye nokusetshenziswa kwe-ginseng kwezokwelapha ngokugcizelela ezinkingeni ze-neurodegenerative. Ijenali Yesayensi Yezemithi, 100(3), 175-186.
UWang, Y., kanye noLiu, J. (2010). I-Ginseng, isu lokuvikela izinzwa elingase libe khona. Umuthi Ohambisanayo Nowehlukile Osekelwe Ebufakazini, 2012.
Yun, TK (2001). Isingeniso esifushane sePanax ginseng CA Meyer. Ijenali ye-Korean Medical Science, 16(Suppl), S3.
Isikhathi sokuthunyelwe: Ephreli-16-2024
