I-Camptotheca Acuminata Extract
I-Camptotheca acuminata extractuhlobo oluhlanganisiwe lwe-camptothecin ehlanganisiwe, etholakala egxolweni nasemaqabungeni esihlahla se-Camptotheca acuminata. I-extract icutshungulwa ukuze iqukathe u-98% min pure camptothecin powder.I-Camptotheciniyi-alkaloid eyenzeka ngokwemvelo ebonise izakhiwo ezithembisayo zokulwa nomdlavuza. Isebenza ngokuvimbela umsebenzi we-enzyme i-topoisomerase, ehilelekile ekuphindaphindweni kwe-DNA kanye nokuhlukaniswa kwamaseli. Ucwaningo luye lwabonisa ukuthi i-camptothecin ingahlasela futhi ibulale amaseli omdlavuza ngempumelelo. Ngakho-ke, lesi sithako sivame ukusetshenziswa ekuthuthukisweni kwemithi yamakhemikhali kanye neminye imithi yokwelapha izinhlobo ezahlukene zomdlavuza. Kodwa-ke, kubalulekile ukuqaphela ukuthi i-camptothecin iyinhlanganisela enamandla futhi kufanele isetshenziswe kuphela ngaphansi kokuqondisa nokuqondiswa kochwepheshe bezokwelapha.
| Igama Lomkhiqizo | I-Camptothecin | Impilo Yeshelufu | iminyaka engu-2 |
| Ingxenye Esetshenzisiwe | impande | Ukubukeka | impuphu ecolekile ephuzi ekhanyayo |
| Imininingwane | 98% | ||
| Isitoreji | Gcina esitsheni esivalwe kahle kude nomswakama kanye nokukhanya kwelanga okuqondile | ||
| Impilo Yeshelufu | Izinyanga ezingu-36 uma zivaliwe futhi zigcinwe kahle | ||
| Indlela Yokubulala Inzalo | Izinga lokushisa eliphezulu, alishisi. | ||
| Into | Imininingwane | Umphumela wokuhlolwa |
| Ukulawula Okungokomzimba | ||
| Ukubukeka | impuphu epinki ekhanyayo | Ukuhambisana |
| Iphunga | Isici | Ukuhambisana |
| Ukunambitha | Isici | Ukuhambisana |
| Ingxenye Esetshenzisiwe | hamba | Ukuhambisana |
| Ukulahlekelwa Kokomisa | ≤5.0% | Ukuhambisana |
| Umlotha | ≤5.0% | Ukuhambisana |
| Indlela Yokukhiqiza | Ukukhishwa kwe-CO2 okubucayi kakhulu | Ukuhambisana |
| Ama-allergen | Akukho | Ukuhambisana |
| Ukulawulwa Kwamakhemikhali | ||
| Izinsimbi ezisindayo | I-NMT 10ppm | Ukuhambisana |
| I-Arsenic | I-NMT 2ppm | Ukuhambisana |
| Umholi | I-NMT 2ppm | Ukuhambisana |
| I-Cadmium | I-NMT 2ppm | Ukuhambisana |
| I-Mercury | I-NMT 2ppm | Ukuhambisana |
| Isimo se-GMO | Ayinayo i-GMO | Ukuhambisana |
| Ukulawulwa Kwezinto Eziphilayo | ||
| Inani Eliphelele Lepuleti | 10,000cfu/g Ubuningi | Ukuhambisana |
| Imvubelo Nokukhunta | 1,000cfu/g Ubuningi | Ukuhambisana |
| I-E.Coli | Okubi | Okubi |
| I-Salmonella | Okubi | Okubi |
(1)Ukuhlushwa okuphezulu:Iqukethe i-98% yempuphu ye-camptothecin emsulwa.
(2)Imvelaphi yemvelo:Kuthathwe ku-Camptotheca acuminata, isihlahla esidabuka eShayina.
(3)Izakhiwo zokulwa nomdlavuza:I-Camptothecin ibonise umsebenzi oqinile wokulwa nomdlavuza.
(4)Inhlanganisela ye-chemotherapy:Isetshenziswa ekwelapheni umdlavuza okuqondiwe.
(5)I-ejenti enamandla yokulwa nomdlavuza:Isebenza kahle ekuvimbeleni ukukhula kwezimila.
(6)Kukhuthaza ukufa kwamangqamuzana omdlavuza:Kubangela i-apoptosis kumaseli omdlavuza.
(7)Okunye ongakwenza esikhundleni sokwelashwa kwendabuko:Inikeza indlela yemvelo yokwelapha umdlavuza.
(8)Umkhiqizo wemvelo ongase ube khona wokulwa nomdlavuza:Kucatshangelwa ucwaningo olwengeziwe kanye nentuthuko.
(9)I-antioxidant enamandla:Kusiza ukulwa nokucindezeleka kwe-oxidative futhi kunciphisa ukulimala kwamangqamuzana.
(10)Ukuphepha kanye nokuqinisekiswa kwekhwalithi:Kwenziwe ngaphansi kwezindinganiso zokulawula ikhwalithi eziqinile.
(1) Izakhiwo zokulwa nomdlavuza:I-Camptothecin, isakhi esiyinhloko esisebenzayo ku-extract ye-acuminata ye-camptotheca, ibonise umsebenzi othembisayo wokulwa nomdlavuza ezifundweni zangaphambi kokwelashwa. Ivimbela i-enzyme i-topoisomerase I, ehilelekile ekuphindaphindweni nasekubhalweni kwe-DNA, ekugcineni okuholela ekuvinjelweni kokukhula kwamaseli omdlavuza.
(2) Umsebenzi we-Antioxidant:Kutholakale ukuthi i-Camptotheca acuminata extract inomsebenzi we-antioxidant, osiza ekunciphiseni ama-free radical ayingozi emzimbeni. Ama-antioxidants angasiza empilweni iyonke ngokuvikela amaseli ekulimaleni okubangelwa ukucindezeleka kwe-oxidative.
(3) Imiphumela yokulwa nokuvuvukala:Ezinye izifundo ziphakamise ukuthi i-camptotheca acuminata extract ingaba nezakhiwo zokulwa nokuvuvukala. Ukuvuvukala kuhlotshaniswa nezifo ezahlukahlukene ezingamahlalakhona, futhi ukunciphisa ukuvuvukala kungaba nomthelela omuhle empilweni iyonke.
(4) Umsebenzi wokulwa namagciwane:Ucwaningo lokuqala lubonise ukuthi i-camptotheca acuminata extract, ikakhulukazi i-camptothecin, ingase ibonise izakhiwo zokulwa namagciwane. Ibonise imiphumela yokuvimbela amagciwane athile, okuhlanganisa igciwane le-herpes simplex kanye negciwane le-cytomegalovirus labantu.
(1) I-Camptotheca acuminata extract ivame ukusetshenziswa ku-imithi yendabuko yaseShayinangenxa yezakhiwo zayo zokulwa nomdlavuza.
(2) Iqukethe i-camptothecin, ikhemikhali yemvelo evimbelaukuphindaphindwa kwamaseli omdlavuza.
(3) Isetshenziswe ku-ukwelashwa ngamakhemikhalikwezinhlobo ezithile zomdlavuza, okuhlanganisa umdlavuza wamaphaphu, wesibeletho, kanye nomdlavuza we-colorectal.
(4) Iphinde yabonisa amandla ekwelapheniizimila zobuchopho kanye ne-leukemia.
(5) Lesi siqeshana sinezakhiwo zokulwa ne-antioxidant futhi singasizavikela ekucindezelekeni kwe-oxidative kanye nomonakalo we-DNA.
(6) Izifundo zibonise ukuthi i-Camptotheca acuminata extract ingaba nemiphumela yokulwa nokuvuvukala, okwenza ibe wusizo ezimweni ezifanaisifo samathambo kanye nesifo samathumbu esivuvukalayo.
(7) Futhi kuyacwaningwa ukuthi kungenzeka yiniukwelapha i-HIV kanye ne-hepatitis.
(8) Isetshenziswa ku-imikhiqizo yokunakekelwa kwesikhumbangenxa yekhono layo lokukhuthaza ukukhiqizwa kwe-collagen nokuthuthukisa ukunwebeka kwesikhumba.
(9) Bekulokhu kusetshenziswa ngokwesikoizakhiwo zayo zokunciphisa ubuhlungu.
(10) Lesi siqephu siseseyindawo yocwaningo esebenzayo, futhi kudingeka izifundo ezengeziwe ukuze kuhlolwe amandla aso ezindleleni ezahlukene zezokwelapha.
(1) Ukuvuna:Isitshalo se-Camptotheca acuminata sivunwa esigabeni esifanele lapho okuqukethwe kwe-camtothecin kuphezulu.
(2) Ukomisa:Izinto zesitshalo ezivuniwe zomiswa kusetshenziswa indlela efanele, njengokomisa ngomoya noma ukomisa ngosizo lokushisa.
(3) Ukugaya:Izinto zesitshalo ezomisiwe zigaywa kahle zibe yimpuphu kusetshenziswa imishini yokugaya.
(4) Ukukhipha:Impuphu egayiwe ifakwa enkambisweni yokukhipha kusetshenziswa isinyibilikisi esifanele, ngokuvamile inhlanganisela yamanzi kanye nezinyibilikisi eziphilayo.
(5) Ukuhlunga:Isixazululo esikhishiwe siyahlungwa ukuze kususwe noma yikuphi ukungcola okuqinile noma izinsalela zezitshalo.
(6) Ukugxila:Isixazululo esihlungiwe sigxishwe ngaphansi kwengcindezi encishisiwe noma ngokuhwamukisa isinyibilikisi ukuze kwandiswe ukugcwala kwe-camptothecin.
(7) Ukuhlanzwa:Izindlela ezengeziwe zokuhlanza, njenge-chromatography, i-crystallization, noma i-solvent partitioning, zingasetshenziswa ukuhlukanisa nokuhlanza i-camptothecin.
(8) Ukomisa:I-camtothecin ehlanziwe iyomiswa ukuze kususwe noma yimuphi umswakama osele.
(9) Ukugaya:I-camtothecin eyomisiwe iyagaywa ukuze kutholakale ifomu eliyimpuphu elicolekile.
(10) Ukulawulwa Kwekhwalithi:Umkhiqizo wokugcina uhlolwa ngokulawula ikhwalithi ngokuqinile ukuqinisekisa ukuthi uhlangabezana nemigomo efiselekayo ye-98% camptothecin.
(11) Ukupakisha:Impuphu ye-camptothecin engu-98% ephumayo ipakishwa ezitsheni ezifanele, ilungele ukusatshalaliswa noma ukucutshungulwa okuqhubekayo.
Indawo Yokugcina: Gcina endaweni epholile, eyomile, nehlanzekile, Vikela emswakama nasekukhanyeni okuqondile.
Iphakheji Elikhulu: 25kg/isigubhu.
Isikhathi Sokuhola: Izinsuku eziyi-7 ngemuva kwe-oda lakho.
Impilo Yeshelufu: Iminyaka emi-2.
Phawula: Ukucaciswa okwenziwe ngezifiso nakho kungafinyelelwa.
I-Express
Ngaphansi kwe-100kg, izinsuku ezi-3-5
Isevisi yokungena emnyango kulula ukuyithatha izimpahla
Ngasolwandle
Ngaphezulu kwama-300kg, cishe izinsuku ezingama-30
Kudingeka umthengisi wezinsizakalo zokukhishwa kwemvume ochwepheshe
Ngomoya
100kg-1000kg, Izinsuku ezi-5-7
Kudingeka umthengisi wezinsizakalo zokuhlanza ochwepheshe kusukela esikhumulweni sezindiza kuya esikhumulweni sezindiza
I-Camptotheca Acuminata Extractiqinisekiswe ngesitifiketi se-ISO, isitifiketi se-HALAL, kanye nesitifiketi se-KOSHER.
Isicanucanu nokuhlanza: I-Camptothecin ngokwayo ingabangela ukuphazamiseka kwamathumbu, okuhlanganisa isicanucanu nokuhlanza. Le miphumela emibi ingalawulwa ngemithi yokulwa nokugabha.
Uhudo:Isifo sohudo singenye imiphumela emibi evamile ye-camptothecin. Ukuthola amanzi anele kanye nemithi efanele yokulwa nesifo sohudo kungadingeka ukuze kulawulwe lo mphumela omubi.
Ukucindezela i-Myelosuppression:I-Camptothecin ingacindezela umongo wethambo futhi ithinte ukukhiqizwa kwamaseli egazi, okuholela ekunciphiseni kwamaseli egazi abomvu namhlophe nama-platelet. Lokhu kungabangela i-anemia, ukwanda kokuthambekela ekuthelelekeni, kanye nengozi eyengeziwe yokopha. Kudingeka ukuhlolwa kwegazi njalo ukuze kuqashwe inani lamaseli egazi ngesikhathi sokwelashwa.
Ukukhathala:Ukukhathala kuwumphumela ovamile wemithi eminingi yamakhemikhali, okuhlanganisa ne-camptothecin. Kubalulekile ukuphumula nokonga amandla ngesikhathi sokwelashwa.
Ukulahlekelwa izinwele:I-Camptothecin ingabangela ukulahleka kwezinwele, okuhlanganisa izinwele zesikhumba, zomzimba kanye nezobuso.
Ingozi yokutheleleka:I-Camptothecin ingawenza buthaka amasosha omzimba, yandise ingozi yokutheleleka. Kubalulekile ukuthatha izinyathelo zokuphepha ukuze kuncishiswe ingozi yokuchayeka ezifweni ezithathelwanayo ngesikhathi sokwelashwa.
Ukusabela kokungezwani komzimba:Abanye abantu bangase babe nokusabela kokungezwani komzimba ne-camptotheca acuminata extract. Izimpawu zingaba zimbi kakhulu futhi zingafaka phakathi ukuqubuka, ukulunywa, ukuphelelwa umoya, nokuvuvukala. Kufanele kufunwe usizo lwezokwelapha ngokushesha uma kwenzeka ukusabela okukhulu kokungezwani komzimba.
Ubuthi besibindi:I-Camptothecin ingabangela ubuthi esibindini, okuholela ekukhuleni kwama-enzyme esibindi kanye nomonakalo wesibindi. Ukuhlolwa kokusebenza kwesibindi kufanele kuhlolwe njalo ngesikhathi sokwelashwa.
Ukusabela kwe-Hypersensitivity:Akuvamile ukuthi abantu babhekane nokusabela kwe-hypersensitivity ku-camptothecin, okungabandakanya izimpawu ezifana nomkhuhlane, ukubanda, kanye nobunzima bokuphefumula. Kufanele kufunwe usizo lwezokwelapha ngokushesha uma kuvela lezi zimpawu.
Kubalulekile ukuxoxa nganoma yimiphi imiphumela emibi engaba khona kanye nezinyathelo zokuphepha nochwepheshe wezempilo ngaphambi kokuqala noma yikuphi ukwelashwa nge-camptotheca acuminata extract. Bangakunikeza iseluleko esiqondene nomuntu ngamunye ngokusekelwe emlandweni wezokwelapha kanye nokwakheka okuqondile kwe-extract esetshenziswayo.
