Umhlinzeki Wefektri I-β-Nicotinamide adenine dinucleotide Ehlanzekile (NAD)
I-β-Nicotinamide adenine dinucleotide (NAD) iyi-coenzyme etholakala kuwo wonke amaseli aphilayo, idlala indima ebalulekile ezinqubweni ezahlukene ze-metabolic. Ibalulekile ekukhiqizweni kwamandla, ukulungiswa kwe-DNA, kanye nokubonisana kwamaseli. I-NAD ikhona ngezindlela ezimbili: i-NAD+ kanye ne-NADH, ezihilelekile ekuphenduleni kwe-redox, zidlulisa ama-electron ngesikhathi sezindlela ze-metabolic. I-NAD ibalulekile ekugcineni ukusebenza kwamaseli kanye nempilo iyonke, futhi amazinga ayo angathinta izinqubo ezahlukene ze-physiological. Isetshenziswa kabanzi kwezemithi, ubuchwepheshe be-bio, kanye nezimboni zokudla, kanye nasekukhiqizweni kwezithasiselo kanye nokudla okusebenzayo okuhlose i-metabolism yamandla kanye nempilo yamaseli. Endaweni yasefektri, i-NAD ingakhiqizwa ngokubilisa, kusetshenziswa ama-microorganism ukuguqula ama-molecule angaphambi kwesikhathi abe yi-NAD. Inqubo yokukhiqiza ihilela ukulawula ngokucophelela izimo zokubilisa ukuze kuthuthukiswe ukuguqulwa kwama-precursor abe yi-NAD.
| Into | Inani |
| Inombolo ye-CAS | 53-84-9 |
| Amanye Amagama | i-beta-Nicotinamide adenine dinucleotide |
| MF | C21H27N7O14P2 |
| Inombolo ye-EINECS | 200-184-4 |
| Indawo Yokuqala | IShayina |
| Uhlobo | IziPhakathi ze-Agrochemical, IziPhakathi ze-Dyestuff, IziPhakathi ze-Flavor & Perfume, IziPhakathi ze-Syntheses Material |
| Ubumsulwa | 99% |
| Isicelo | Izinto Zokwenziwa Eziphakathi |
| Ukubukeka | Impuphu emhlophe |
| Igama | i-beta-Nicotinamide adenine dinucleotide |
| MW | 663.43 |
| MF | C21H27N7O14P2 |
| Ifomu | Okuqinile |
| Ukubukeka | Impuphu emhlophe |
| I-MOQ | 1kg |
| Amasampula | Kuyatholakala |
| Impilo Yeshelufu | iminyaka engu-2 |
Ukuhlanzeka Okuphezulu:I-NAD yethu ikhiqizwa kusetshenziswa izinqubo zokukhiqiza ezithuthukisiwe ukuqinisekisa ubumsulwa obuphezulu, ihlangabezana nezindinganiso zekhwalithi eziqinile ezidingekayo kwezokwelapha, ubuchwepheshe be-bio, kanye nezicelo zokudla.
Ikhwalithi Ehambisanayo:Sigcina izinyathelo eziqinile zokulawula ikhwalithi kuyo yonke inqubo yokukhiqiza ukuqinisekisa ukuthi imikhiqizo yethu ye-NAD ihlangabezana njalo nezimfuneko ezidingekayo kanye nezindinganiso zokusebenza.
Izicelo Ezihlukahlukene:I-NAD yethu ingasetshenziswa ezinhlobonhlobo zezicelo, okuhlanganisa imithi, izithasiselo zokudla, ukudla okusebenzayo, kanye nezinqubo ze-biotechnology, ngenxa yendima yayo ebalulekile ekusetshenzisweni kwamaseli nasekukhiqizweni kwamandla.
Ukuthobela Imithetho:Imikhiqizo yethu ye-NAD ilandela izindinganiso zomthetho zomhlaba wonke, iqinisekisa ukuhambisana neziqondiso nemithethonqubo efanele yokuphepha nekhwalithi.
Ukunikezwa Okuthembekile:Sinekhono lokukhiqiza kanye namakhono okuthutha ukuze sinikeze ukuhlinzekwa okuthembekile nokungaguquguquki kwe-NAD ukuze kuhlangatshezwane nezidingo zamakhasimende ethu.
Ukusekela kwezobuchwepheshe:Ithimba lethu lochwepheshe linganikeza ukwesekwa kwezobuchwepheshe kanye nesiqondiso ekusebenziseni i-NAD ezinhlelweni ezahlukahlukene, ukuqinisekisa ukuthi amakhasimende ethu angasebenzisa izinzuzo zemikhiqizo yethu.
Sekukonke, imikhiqizo yethu ye-NAD ibonakala ngobumsulwa bayo obuphezulu, ikhwalithi engaguquguquki, ukuguquguquka, ukuhambisana nemithetho, ukuhlinzekwa okuthembekile, kanye nokusekelwa kobuchwepheshe okuphelele, okwenza ibe yindawo ekahle kakhulu yezinhlelo zokusebenza ezahlukahlukene zezimboni nezentengiselwano.
I-β-Nicotinamide adenine dinucleotide (NAD) emsulwa inikeza imisebenzi eminingana kanye nezinzuzo ezingaba khona zezempilo, okuhlanganisa:
Ukukhiqizwa Kwamandla:
I-NAD idlala indima ebalulekile ekukhiqizweni kwe-adenosine triphosphate (ATP), uhlobo lwemali oluyinhloko lwamandla lweseli. Ngokuhlanganyela ekuphenduleni kwe-redox, i-NAD yenza kube lula ukudluliselwa kwama-electron enkambisweni ye-oxidative phosphorylation, ebalulekile ekukhiqizeni i-ATP ku-mitochondria.
Ukuguqulwa Kweseli:
I-NAD ibandakanyeka ezindleleni ezahlukahlukene ze-metabolic, okuhlanganisa i-glycolysis, umjikelezo we-triccarboxylic acid (TCA), kanye ne-oxidation yama-fatty acid. Lezi zinqubo ziyisisekelo sokuqhekeka nokusetshenziswa kwezakhamzimba ekukhiqizweni kwamandla kanye nokusebenza kwamaseli.
Ukulungiswa kwe-DNA:
I-NAD iyi-substrate ehlanganisiwe yama-enzyme ahilelekile ezinqubweni zokulungisa i-DNA, njenge-poly(ADP-ribose) polymerases (PARPs) kanye ne-sirtuins. Lawa ma-enzyme adlala indima ebalulekile ekugcineni ukuzinza kwe-genomic kanye nokulungisa umonakalo we-DNA obangelwa yizinto ezihlukahlukene ezibangela ukucindezeleka.
Ukubonisana Kweseli:
I-NAD isebenza njengesisekelo sama-sirtuin, uhlobo lwamaprotheni ahilelekile ekulawuleni izinqubo zamaseli njengokubonakaliswa kwezakhi zofuzo, i-apoptosis, kanye nokusabela kokucindezeleka. Ama-Sirtuin ahilelekile ekuphileni isikhathi eside futhi ahlotshaniswa nezinzuzo ezingaba khona zezempilo.
Izinzuzo Ezingaba Khona Zempilo:
Ucwaningo luphakamisa ukuthi ukwengezwa noma ukuguqulwa kwe-NAD kwamazinga e-NAD kungaba nezinzuzo ezingaba khona zempilo, okuhlanganisa ukusekela ukusebenza kwe-mitochondrial, ukukhuthaza ukuguga okunempilo, kanye nezimo ezingaba nomthelela ezihambisana nokungasebenzi kahle kwe-metabolic kanye nokucindezeleka kwamaseli.
I-β-Nicotinamide adenine dinucleotide (NAD) emsulwa inezinhlobo ezahlukene zezicelo kuzo zonke izimboni ngenxa yendima yayo ebalulekile ekusetshenzisweni kwamaseli kanye nokukhiqizwa kwamandla. Ezinye zezicelo ezibalulekile ze-NAD emsulwa zifaka:
Imboni Yezemithi:
I-NAD isetshenziswa njengengxenye ebalulekile ekwakhiweni kwemithi, ikakhulukazi emithini ehlose ukuphazamiseka kwe-metabolic, ukungasebenzi kahle kwe-mitochondrial, kanye nezimo ezihlobene nobudala. Iphinde isetshenziswe ocwaningweni nasekuthuthukisweni kokungenelela okungenzeka kokwelapha.
Izithasiselo Zokudla:
I-NAD ifakwa ezithasiseleni zokudla ezihlose ukusekela impilo yamaseli, ukwakheka kwamandla, kanye nenhlalakahle iyonke. Lezi zithasiseleli zithengiswa ngenxa yamandla azo okukhuthaza ukuguga okunempilo kanye nokusebenza kwe-metabolic.
Ukudla Okusebenzayo Neziphuzo:
I-NAD isetshenziswa ekuthuthukisweni kokudla neziphuzo ezisebenzayo ezenzelwe ukusekela ukukhiqizwa kwamandla, impilo yamaseli, kanye nokulinganisela kwe-metabolic. Le mikhiqizo ingabhekisa kubathengi abafuna izindlela zemvelo zokuthuthukisa impilo yabo iyonke kanye namandla abo.
I-Biotechnology:
I-NAD isetshenziswa ezinqubweni ezahlukahlukene ze-biotechnological, okuhlanganisa ukukhuliswa kwamaseli, ukubiliswa, kanye nobunjiniyela be-enzyme. Isebenza njenge-cofactor ebalulekile ekuphenduleni okuningi kwe-enzyme kanye nezindlela ze-metabolic, okwenza ibe usizo ekucutshungulweni kwezinto eziphilayo kanye nasekukhiqizweni kwezinto eziphilayo.
Ucwaningo Nentuthuko:
I-NAD isetshenziswa njengethuluzi lokucwaninga emalabhorethri ezemfundo kanye nezimboni ukutadisha imetabolism yamaseli, ukukhiqizwa kwamandla, kanye nezinzuzo zezempilo ezingaba khona ezihlobene nokuguqulwa kwe-NAD. Futhi kuyisihloko socwaningo lwesayensi ngemiphumela yayo ekugugeni, ezifweni zemetabolism, kanye nezimo zokonakala kwemizwa.
Izimonyo:
I-NAD ifakwa emikhiqizweni yokunakekelwa kwesikhumba kanye nezimonyo ngenxa yamandla ayo okusekela impilo yamangqamuzana kanye namandla. Imakethwa njengesithako esinezakhiwo zokulwa nokuguga kanye nokuvuselela ubusha.
I-Extract yethu esekelwe ezitshalweni ikhiqizwa kusetshenziswa izindlela zokulawula ikhwalithi eziqinile futhi ilandela amazinga aphezulu ezinqubo zokukhiqiza. Sibeka phambili ukuphepha nekhwalithi yomkhiqizo wethu, siqinisekisa ukuthi uhlangabezana nezidingo zomthetho kanye nezitifiketi zemboni. Lokhu kuzibophezela kwikhwalithi kuhlose ukwakha ukwethembana nokuqiniseka ekuthembekeni komkhiqizo wethu. Inqubo yokukhiqiza ejwayelekile imi kanje:
Indawo Yokugcina: Gcina endaweni epholile, eyomile, nehlanzekile, Vikela emswakama nasekukhanyeni okuqondile.
Iphakheji Elikhulu: 25kg/isigubhu.
Isikhathi Sokuhola: Izinsuku eziyi-7 ngemuva kwe-oda lakho.
Impilo Yeshelufu: Iminyaka emi-2.
Phawula: Ukucaciswa okwenziwe ngezifiso nakho kungafinyelelwa.
25kg/ibhokisi
Ukupakisha okuqinisiwe
Ukuphepha kwempahla
I-Express
Ngaphansi kwe-100kg, izinsuku ezi-3-5
Isevisi yokungena emnyango kulula ukuyithatha izimpahla
Ngasolwandle
Ngaphezulu kwama-300kg, cishe izinsuku ezingama-30
Kudingeka umthengisi wezinsizakalo zokukhishwa kwemvume ochwepheshe
Ngomoya
100kg-1000kg, Izinsuku ezi-5-7
Kudingeka umthengisi wezinsizakalo zokuhlanza ochwepheshe kusukela esikhumulweni sezindiza kuya esikhumulweni sezindiza
I-Bioway ithola izitifiketi ezifana nezitifiketi ze-USDA kanye ne-EU organic, izitifiketi ze-BRC, izitifiketi ze-ISO, izitifiketi ze-HALAL, kanye nezitifiketi ze-KOSHER.
