I. Isingeniso
Phospholipidsziyizakhi ezibalulekile ezifundweni zemvelo futhi zidlala izindima ezibalulekile ezinhlanganweni ezahlukahlukene zomzimba. Ukuqonda ukwakheka kwabo kanye nomsebenzi wabo kubalulekile ukuze kuqondiswe ubunzima be-biology yamaselula kanye nama-molecular, kanye nokubaluleka kwabo empilweni yabantu nasezifo. Lokhu kubuka konke okuphelele kuhlose ukudonsa kuhlobo oluyinkimbinkimbi lwama-phospholipids, ukuhlola incazelo nesakhiwo sabo, kanye nokugqamisa ukubaluleka kokufunda la ma-molecule.
A. Ukuchazwa kanye nokwakheka kwama-phospholipids
I-Phospholipids iyisigaba sama-lipid aqukethe amaketanga amabili amafutha acid acid, iqembu le-phospsate, kanye ne-glycerol backbone. Isakhiwo esiyingqayizivele sama-phospholipid sibenza bakwazi ukwakha i-lipid bilayer, isisekelo se-membranes yeseli, nemisila ye-hydrophobic ebheke ngaphakathi kanye namakhanda we-hydrophilic abheke ngaphandle. Leli lungiselelo lihlinzeka ngesithiyo esishukumisayo esilawula ukuhamba kwezinto ngaphambi nangaphandle kweseli, ngenkathi liphinda futhi lingenelela izinqubo ezahlukahlukene ezifana nokusayina nokuhamba.
B. Ukubaluleka kokufunda ama-phospholipids
Ukutadisha ama-phospholipids kubalulekile ngenxa yezizathu eziningana. Okokuqala, zibalulekile esakhiweni nasekusebenzeni kolwelwesi lwamaseli, kuthonya uketshezi lwe-membrane, ukuqina nokuqina. Ukuqonda izakhiwo ze-phospholipids kubalulekile ekuvuthweni kwezindlela ezingaphansi kwezinqubo zeselula ezifana ne-endocytosis, execytosis, kanye nokudluliselwa kwesiginali.
Ngaphezu kwalokho, ama-phospholipid anemiphumela ebalulekile yempilo yabantu, ikakhulukazi mayelana nemibandela efana nesifo senhliziyo, ukuphazamiseka kwe-neurodegenerative, kanye nezinyembezi ze-metabolic. Ucwaningo kuma-phospholipids lunganikeza ukuqonda ekuthuthukisweni kwamasu okulashwa kwenoveli kanye nokungenelela kokudla okubhekisele kulezi zinkinga zezempilo.
Ngaphezu kwalokho, ukusetshenziswa kwezimboni nezentengiselwano kwama-phospholipid ezindaweni ezinjengemithi, amakhambi okudla okunempilo, kanye ne-biotechnology kugcizelela ukubaluleka kokuthuthukisa ulwazi lwethu kule nkambu. Ukuqonda izindima ezahlukahlukene ze-phospholipids kungaholela ekuthuthukisweni kwemikhiqizo emisha nobuchwepheshe obunemvelaphi ebanzi yokufinyelela ekuthuthukisweni komuntu kanye nentuthuko yezobuchwepheshe.
Ngamafuphi, ukutadisha ama-phospholipids kubalulekile ekwambuleni isayensi eyinkimbinkimbi ngemuva kokwakheka kwamaselula kanye nomsebenzi, ukuhlola umthelela wabo empilweni yabantu, kanye nokufaka amandla abo ahlukahlukene ezimbonini. Lokhu kubuka konke okuphelele kuhlose ukukhanyisela imvelo ehlukahlukene yama-phospholipid kanye nokubaluleka kwawo ezindaweni zokucwaninga ngemvelo, impilo yabantu, kanye nobuchwepheshe obusha.
II. Imisebenzi yemvelo yama-phospholipids
I-Phospholipids, isakhi esibucayi solwelwesi lwamaseli, dlala izindima ezahlukahlukene ukuze ulondoloze ukwakheka kwamaselula nokusebenza, kanye nomthelela ezinqubweni ezahlukahlukene zomzimba. Ukuqonda imisebenzi yemvelo yama-phospholipids kuhlinzeka ngokuqonda ngokubaluleka kwawo empilweni nasezifo.
A. Iqhaza kusakhiwo se-membrane kanye nomsebenzi
Umsebenzi oyinhloko wezinto eziphilayo ze-phospholipids umnikelo wazo esakhiweni nasekusebenzeni kolwelwesi lwamaseli. I-Phospholipids yakha i-lipid bilayer, uhlaka oluyisisekelo lwe-membranes yeseli, ngokuzihlelela ngemisila yazo e-hydrophobic ngaphakathi nangaphandle kwe-hydrophilic ngaphandle. Lesi sakhiwo sakha ulwelwesi olungaguquki olulawula ukudlula kwezinto ngaphakathi nangaphandle kweseli, ngaleyo ndlela ligcine i-homeostasis yamaselula futhi lula imisebenzi ebalulekile njengokuthathwa kwezakhi, ukungcola kwemfucuza, kanye nokusayinwa kweseli.
B. Ukusayina nokuxhumana kumaseli
I-Phospholipids nayo isebenza njengezakhi ezibalulekile ze-Signaling Patways kanye nokuxhumana kweseli. Ama-phospholipipids athile, afana nePhosphatidylinolitol, asebenze njengabendulele ukusayina ama-molekyuli (isib. Lawa ma-molekyuli asayina adlala izindima ezibalulekile kuma-cascade ahlukahlukene okusayina ama-intracellular kanye nezolamphakathi, ethonya izimpendulo ezahlukahlukene zomzimba kanye nokuziphatha kwamaselula.
C. Igalelo kubuchwepheshe bempilo yobuchopho nomsebenzi wokuqonda
I-Phospholipids, ikakhulukazi i-phosphatidylcholine, ne-phosphatidylserine, ziningi ebuchosheni futhi zibalulekile ukuze zilondoloze ukwakheka kwayo nokusebenza kwayo. I-Phospholipids ifaka isandla ekwakhekeni nasekuqineni kolwelwesi lwe-neuronal, usizo ekukhishweni kwe-neurotransmitter futhi libandakanyeka, futhi libandakanyeka e-synaptic Plastic, okubalulekile. Ngaphezu kwalokho, ama-phospholipids adlala indima ezinhlelweni zezinzwa futhi avele abhekane nokwehla kwengqondo okuhambisana nokuphazamiseka kokuguga nokuma nobuntu.
D. Umthelela Emsebenzini Wezempilo Nenhliziyo
I-Phospholipids ikhombisile imiphumela ebalulekile emsebenzini wenhliziyo kanye nomsebenzi wenhliziyo. Babambe iqhaza esakhiweni nasekusebenzeni kwama-lipoproteins, athutha i-cholesterol namanye ama-lipid asegazini. I-Phospholipids ngaphakathi kwama-lipoprotein inikela ngokuqina kwawo kanye nokusebenza kwabo, ithonya i-lipid metabolism ne-cholesterol homeostasis. Ngokwengeziwe, ama-phospholipids afundwe amandla awo aguqule amaphrofayili egazi le-lipid futhi anciphise ubungozi bezifo zenhliziyo, aqokomise imiphumela yabo yokungabikho yokulapha ekuphatheni impilo yenhliziyo.
E. Ukubandakanyeka ku-lipid metabolism kanye nokukhiqizwa kwamandla
Ama-phospholipids ahlanganiswe ku-lipid metabolism kanye nokukhiqizwa kwamandla. Babandakanyeka ekuhlanganiseni nasekuqhekekeni kwama-lipid, kufaka phakathi ama-triglycerides ne-cholesterol, futhi badlale izindima ezibucayi eLipid ezokuhamba kanye nesitoreji. I-Phospholipids ibuye ibe nomthelela ekusebenzeni kwe-mitochondrial kanye nokukhiqizwa kwamandla ngokuzibandakanya kwabo kwi-phosphorylation yabo kanye ne-elektroni yokuhamba, kugcizelela ukubaluleka kwawo ku-metabolism yamandla kagesi.
Ngokufingqwa, imisebenzi yemvelo yama-phospholipids ayiminyene futhi ifaka izindima zawo nge-membrane ye-membrane kanye nomsebenzi, umthelela ekusebenzeni kwengqondo kanye nomsebenzi wenhliziyo, nokuzibandakanya ku-lipid metabolism kanye nokukhiqizwa kwamandla. Lokhu kubuka konke okuphelele kuhlinzeka ngokuqonda okujulile kwemisebenzi yemvelo ehlukahlukene yama-phospholipids kanye nemiphumela yawo yempilo yabantu nenhlala-kahle.
III. Izinzuzo zezempilo ze-phospholipids
I-Phospholipids iyizakhi ezibalulekile zomelweli weseli ngezindima ezahlukahlukene empilweni yabantu. Ukuqonda izinzuzo zezempilo zama-phospholipids kungasikhanyisela ngezicelo zazo zokwelapha ezingaba khona kanye nokunempilo.
Imiphumela kumazinga we-cholesterol
Ama-phospholipids adlala indima ebalulekile ku-lipid metabolism kanye nezokuthutha, okuthinta ngqo amazinga e-cholesterol emzimbeni. Ucwaningo lukhombisile ukuthi ama-phospholipids angalingisa i-cholesterol metabolism ngokuthinta ukuhlanganiswa, ukumuncwa, kanye ne-excretion ye-cholesterol. Kubikwe ama-phospholipipipipipipipipipit ukuze kusiza ekuqinisekisweni nasekunyuleni kwamafutha okudla, ngaleyo ndlela kusiza ukumuncwa kwe-cholesterol emathunjini. Ngokwengeziwe, ama-phospholipids abandakanyeka ekwakhekeni kwama-lipoproteints aphezulu we-lipoproteins (HDL), ezaziwa ngendima yawo ekususeni i-cholesterol eyeqile egazini, ngaleyo ndlela anciphise ubungozi be-atherosteosis kanye nezifo zenhliziyo. Ubufakazi buveza ukuthi ama-phospholipid angaba namandla okuthuthukisa amaphrofayili we-lipid futhi afake isandla ekugcinweni kwamazinga we-cholesterol anempilo emzimbeni.
Izakhiwo ze-antioxidative
I-Phospholipids ibonisa izakhiwo ze-antioxidative efaka isandla emiphumeleni yazo ezuzisayo empilweni. Njengezakhi ezihlanganayo ze-membranes yamaselula, ama-phospholipids atholakala kumonakalo oxidative ngama-radicals wamahhala nezinhlobo ze-oksijini ezisebenzayo. Kodwa-ke, ama-phospholipids anawo umthamo we-antioxidative wezemvelo, osebenza njenge-scavenger yama-radicals wamahhala futhi avikele amaseli ekucindezelekeni oxidative. Ucwaningo lukhombisile ukuthi ama-phospholipid athile, njenge phosphatidylcholine ne-phosphatidliwayonethanolamine, anganciphisa ngempumelelo ukulimala kwe-oxidative futhi avimbele i-lipid peroxidation. Ngaphezu kwalokho, ama-phospholipids afakiwe ekuthuthukiseni uhlelo lokuvikela ama-antioxidant ngaphakathi kwamaseli, ngaleyo ndlela afake ithonya elivikela ukulimazeka oxetitive kanye nama-pathologies ahlobene nawo.
Izicelo ezingaba khona zokwelapha kanye nokudla okunempilo
Izinzuzo zezempilo ezihlukile ze-phospholipids ziye zakhiqiza inzalo ngezicelo zazo zokwelapha ezingaba khona kanye nokudla okunempilo. Izindlela zokwelapha ezisuselwa ku-phospholipid ziyahlolwa ngenxa yamandla abo ekuphatheni ukuphazamiseka okuhlobene ne-lipid, njenge-hypercholestolemia ne-dyslipidemia. Ngaphezu kwalokho, ama-phospholipids akhombise isithembiso ekuthuthukiseni impilo yesibindi nokusekela umsebenzi wesibindi, ikakhulukazi ezimeni ezibandakanya i-hepatic lipid metabolism kanye nengcindezi ye-oxidative. Izicelo zokudla okunempilo kwama-phospholipids sezibonwe endaweni yokudla okusebenzayo kanye nezithasiselo zokudla, lapho kusungulwa khona ukwakhiwa kwe-phospholipid ukuthuthukisa ukutholwa kwe-LIPID, ukukhuthaza impilo yenhliziyo, kanye nokusekelwa inhlala-kahle.
Ekuphetheni, izinzuzo zezempilo zama-phospholipids zibandakanya imiphumela yazo emazingeni e-cholesterol, izakhiwo ze-antioxidative, kanye nezicelo zazo zokwelapha ezingaba khona. Ukuqonda izindima ezihlangene zama-phospholipid ngokugcina i-homeostasis yomzimba kanye nokunciphisa ubungozi bezifo kuhlinzeka ngokuqonda okubalulekile ekubaluleni kwazo ekuthuthukiseni impilo yomuntu nenhlala-kahle.
IV. Imithombo yama-phospholipids
Ama-phospholipids, njengezakhi ze-lipid ezibalulekile ze-membranes yamaselula, zibalulekile ekugcineni ubuqotho kanye nokusebenza kwamaseli. Ukuqonda imithombo yama-phospholipids kubaluleke kakhulu ukwazisa ukubaluleka kwawo kuzo zombili izinsizakalo zokudla okunempilo kanye nezinsizakalo zezimboni.
A. Imithombo yokudla
Imithombo yokudla: I-Phospholipids ingatholakala emithonjeni ehlukahlukene yokudla, neminye yemithombo ecebe kakhulu ibe yi-yolk yeqanda, inyama ye-organ, kanye nama-soya. Amaqanda amaqanda amaningi ikakhulukazi ePhosphatidylcholine, uhlobo lwe-phospholipid, kanti ama-soya aqukethe i-phosphatidylserine ne-phosphatidliwayonositol. Eminye imithombo yokudla yama-phospholipids ifaka imikhiqizo yobisi, amantongomane nembewu yelanga.
Ukubaluleka Kwemvelo: Ukudla kwe-phospholipids kubalulekile ekudleni komuntu futhi kudlale izindima ezibalulekile ezinhlanganweni ezahlukahlukene zomzimba. Lapho esekwe, ama-phospholipids agaywe futhi agaywe emathunjini amancane, lapho asebenza khona njengamabhulokhi wokwakha ama-membrane weseli womzimba futhi anikele ekwakhekeni kwe-cholesterol kanye ne-triglycerides.
Imiphumela Yezempilo: Ucwaningo selukhombisile ukuthi ama-phospholipid okudla angahle abe nezinzuzo zezempilo, kufaka phakathi ukuthuthukisa umsebenzi wesibindi, ukusekela impilo yobuchopho, kanye nokufaka isandla empilweni yenhliziyo. Ngaphezu kwalokho, ama-phospholipids asuselwa emithonjeni yasolwandle, njengamafutha aseKrill, athole ukunakwa ngezakhiwo zawo zokulwa nokuvuvukala kanye ne-antioxidant.
B. Imithombo Yezimboni Nezemithi
Ukukhishwa kwezimboni: I-Phospholipids nayo itholakala emithonjeni yezimboni, lapho ikhishwe khona ngezinto zokwenziwa zemvelo ezinjenge-soybeans, imbewu yelanga, kanye ne-rapeseeds. Lawa ma-phospholipids bese acutshungulwa futhi asetshenziswe ezinhlelweni ezahlukahlukene zezimboni, kufaka phakathi ukukhiqizwa kwama-emulsifiers, izinkundla, kanye nama-ejenti wokudla, amakhambi kanye nezimboni zezimonyo.
Izicelo zezemithi: I-Phospholipids idlala indima enkulu embonini yezemithi, ikakhulukazi ezinhlelweni zokulethwa kwezidakamizwa. Zisetshenziswa njengezinhlelo ze-ExcuPient ekwakhekeni kwezinhlelo ze-Lipid ezisuselwa kwezidakamizwa ukuthuthukisa ama-bioavailability, ukuqina kanye nokuqondiswa kwamakhompiyutha emithi. Ngokwengeziwe, ama-phospholipids ahlolisisiwe ngenxa yamandla abo ekwakheni izithwali zezidakamizwa zokulethwa kwezidakamizwa okuhlosiwe nokukhishwa okuqhubekayo kokulashwa.
Ukubaluleka Kwezimboni: Izinsizakusebenza zezimboni ze-phospholipids zandisa ngaphezu kwemithi ukufaka ukusetshenziswa kwazo ekukhiqizweni kokudla, lapho zisebenza njengama-emulsifiers kanye nokuzinza ngokudla okuhlukahlukene okusetshenzwe. I-Phospholipids nayo isetshenziswa ekukhiqizeni ukunakekelwa komuntu siqu kanye nemikhiqizo yezimonyo, lapho banikela khona ekuzinzeni nasekusebenzeni kokwakhiwa okufana nokhilimu, ama-lotion kanye nama-liposomes.
Ekuphetheni, ama-phospholipids atholwa kuwo wonke umsuka wokudla kanye nezezimboni, edlala izindima ezibalulekile ekudleni komuntu, ezempilo nasezinhlungwini zezimboni ezahlukahlukene. Ukuqonda imithombo ehlukahlukene kanye nokusetshenziswa kwama-phospholipids kubalulekile ekwaziseni ukubaluleka kwawo ekudla okunempilo, kwezempilo kanye nasezimboni.
V. Ucwaningo kanye Nezicelo
A. Izitayela zocwaningo zamanje ePhospholipid
Ucwaningo lwamanje lweSayensi ku-phospholipid isayensi luhlanganisa uhlu oluningi lwezihloko ezigxile ekuqondeni ukwakheka, ukusebenza, kanye nezindima ze-phospholipid ezinqubweni ezahlukahlukene zebhayoloji. Izitayela zakamuva zifaka ukuphenya izindima ezithile amakilasi ahlukene ama-phospholipids adlala ngokusayina kweseli, amandla ashukumo kanye ne-lipid metabolism. Ngokwengeziwe, kunentshisekelo enkulu ekuqondeni ukuthi ukuguqulwa kwe-phospholipid kungaba nomthelela kanjani emzileni we-phospholipid, kanye nokuthuthukiswa kwamasu amasha wokuhlaziya okufunda ama-phospholipid kumazinga amaselula nama-molecular.
B. Izicelo zezimboni nezemithi
Ama-phospholipids athole izinhlelo eziningi zezimboni nezemithi ngenxa yezakhiwo zazo ezihlukile nezemakhemikhali. Emkhakheni wezimboni, ama-phospholipids asetshenziswa njenge-emulsifiers, abaqinisi, kanye nama-ejenti avumelanayo ekudleni, izimboni, kanye nezimboni zokunakekelwa komuntu. Emikhakheni, ama-phospholipids asetshenziswa kabanzi ezinhlelweni zokulethwa kwezidakamizwa, kufaka phakathi ama-liposomes kanye nokwakheka okusekwe kwi-lipid, ukuthuthukisa i-solubity kanye ne-bioavailability yezidakamizwa. Ukusetshenziswa kwama-phospholipids kulezi zicelo kunwebe kakhulu umthelela wawo ongaba khona ezimbonini ezahlukahlukene.
C. Izikhombisi ezizayo nezinselelo ku-phospholipid ucwaningo
Ikusasa locwaningo lwe-phospholipid liphethe isithembiso esihle, ngezindlela ezingaba khona ezibandakanya ukuthuthukiswa kwezinto ezisuselwa kunoveli ze-photospolipid zezicelo ze-biotechnological kanye ne-nanotechnological, kanye nokuhlolwa kwama-phospholipids njengezisulu zokungenelela kokwelapha. Izinselelo zizofaka ukubhekana nezinkinga ezihlobene nokukhubazeka, ukuvela kabusha, kanye nokusebenza kwezindleko zemikhiqizo esekwe kwi-phospholipid. Ngaphezu kwalokho, ukuqonda ukusebenzisana okuyinkimbinkimbi phakathi kwama-phospholipids kanye nezinye izinto zamaselula, kanye nezindima zawo ezinqubweni zezifo, kuzoba indawo ebalulekile yophenyo oluqhubekayo.
D.Phospholipid liposomalImikhiqizo ye-serial
Imikhiqizo ye-Phospholipid Liposomal iyindawo ebalulekile yokugxila ezisetshenzisweni zemithi. Ama-liposomes, okuyi-vesicles eyindilinga eyakhiwa ama-phospholipid ababili, afundwe kakhulu njengezinhlelo ezingaba khona kwezidakamizwa. Le mikhiqizo inikela ngezinzuzo ezinjengekhono lokufaka ama-hydrophobic kanye nemithi ye-hydrophilic, ihlose izicubu noma amaseli athile, futhi unciphise imiphumela emibi yezidakamizwa ezithile. Ukucwaninga okuqhubekayo kanye nentuthuko kuhlose ukuthuthukisa ukuqina, umthamo olayisha izidakamizwa, kanye namakhono okuqondisa imikhiqizo ye-phospholipid esekelwe e-liposolid ehlukahlukene yezicelo zokwelapha.
Lokhu kubuka konke okuphelele kuhlinzeka ngokuqonda emkhakheni we-burgeoning ocwaningweni lwe-phospholipid, kufaka phakathi izitayela zamanje, izinhlelo zezimboni kanye nemithi, izinkomba nezinselelo zesikhathi esizayo, kanye nokuthuthukiswa kwemikhiqizo ye-phososolipid-esekwe ku-liposomisol-based Liposomisols-based Liposomisol-based Liposomisod-based Liposolid. Lolu lwazi luqokomisa imiphumela namathuba ahlukahlukene ahambisana nama-phospholipids emikhakheni ehlukahlukene.
VI. Ukugcina
A. Isifinyezo Sokutholakele Okusemqoka
I-Phospholipids, njengezakhi ezibalulekile zolwelwesi lwebhayoloji, dlala izindima ezibalulekile ekugcinweni kwesakhiwo kanye nomsebenzi. Ucwaningo seluveze izindima ezahlukahlukene zama-phospholipids ekusayineni kwamaselula, i-membrane dynamics, kanye ne-lipid metabolism. Amakilasi athile ama-phospholipids atholakele ukuthi anokusebenza okuhlukile ngaphakathi kwamaseli, izinqubo ezithonya ezifana nokwehlukanisa iseli, ukwanda, kanye ne-apoptosis. Ngaphezu kwalokho, ukuxhumeka okuyinkimbinkimbi phakathi kwama-phospholipids, amanye ama-lipid, namaprotheni alwelwelwe ulwelwesi aqhamuke njengophawu olubalulekile lomsebenzi weselula. Ngokwengeziwe, ama-phospholipid anezicelo ezibalulekile zezimboni, ikakhulukazi ekukhiqizweni kwama-emulsifiers, abaqinisi, kanye nezinhlelo zokulethwa kwezidakamizwa. Ukuqonda ukwakheka nokusebenza kwama-phospholipids kuhlinzeka ngokuqonda ekusetshenzisweni kwawo okungaba khona kanye nokusetshenziswa kwezimboni.
B. Imiphumela Yezempilo Nezimboni
Ukuqonda okuphelele kwama-phospholipids kunemiphumela ebalulekile kubo bobabili impilo nemboni. Ngokwesimo sempilo, ama-phospholipids abalulekile ekugcineni ukuthembeka kwamaselula nokusebenza. Ukungalingani ekwakhiweni kwe-phospholipid kuhlotshaniswe nezifo ezahlukahlukene, kufaka phakathi ukuphazamiseka kwe-metabolic, izifo ze-neurodegenerative, umdlavuza. Ngakho-ke, ukungenelela okuhlosiwe ukuguqula i-phospholipid metabolism nomsebenzi kungenzeka ube namandla okulashwa. Ngaphezu kwalokho, ukusetshenziswa kwama-phospholipids ezinhlelweni zokulethwa kwezidakamizwa kunikeza izindlela ezithembisayo zokuthuthukisa ukusebenza kahle kanye nokuphepha kwemikhiqizo yezemithi. Emkhakheni wezimboni, ama-phospholipids aqukethe ukukhiqizwa kwemikhiqizo ehlukahlukene yabathengi, kufaka phakathi ama-emulsions okudla, izimonyo kanye nokwakhiwa kwemithi. Ukuqonda ubudlelwano bomsebenzi we-Phospholipids bungashayela izinto ezintsha kulezi zimboni, okuholele ekuthuthukisweni kwemikhiqizo yenoveli ngokuqina okuthuthukile kanye ne-bioavailability.
C. Amathuba okuqhubeka nocwaningo kanye nentuthuko
Ukucwaninga okuqhubekayo ku-phospholipid isayensi ye-phospholipid kuveza izindlela eziningi zokuhlola nokuthuthuka okuqhubekayo. Indawo eyodwa ebalulekile ukucaciswa kwezindlela zamangqamuzana ezisindelayo ukubandakanyeka kwama-phospholipids ezindaweni ezisayinayo nezifo. Lolu lwazi lungavuswa ukuthuthukisa izindlela zokwelapha ezihlosiwe ezishintsha i-phospholipid metabolism yenzuzo yokwelapha. Ngokwengeziwe, kuqhubeka uphenyo ngokusetshenziswa kwama-phospholipids njengezimoto zokulethwa kwezidakamizwa kanye nokuthuthukiswa kwezindlela zokwakheka kwe-Lovel Lipid zizothuthukisa inkambu yezemithi. Emkhakheni wezimboni, ukucwaninga okuqhubekayo kanye nemizamo yentuthuko kungagxila ekuthuthukiseni izinqubo zokukhiqiza kanye nokusetshenziswa kwemikhiqizo esekwe kwi-phospholipid ukufeza izimfuno zezimakethe zabathengi ezahlukahlukene. Ngaphezu kwalokho, kuhlola imithombo enobungani eqhubekayo nemvelo yama-phospholipids okusetshenziswa kwezimboni kungenye indawo ebalulekile yentuthuko.
Ngakho-ke, ukubuka konke okuphelele kwesayensi ye-phospholipid kuqokomisa ukubaluleka okubucayi kwama-phospholipids emsebenzini wamaselula, amandla abo okulashwa ezokunakekelwa kwempilo, kanye nezicelo zazo ezahlukahlukene zezimboni. Ukuhlolwa okuqhubekayo kocwaningo lwe-phospholipid kuveza amathuba ajabulisayo okubhekana nezinselelo ezihlobene nezempilo nokushayela okusha ezimbonini ezahlukahlukene.
Izinkomba:
UVance, de, & Ridgway, ND (1988). I-methylation ye-phosphatidylethanolamine. Inqubekela phambili ekucwaningweni kwe-lipid, 27 (1), 61-79.
Cui, Z., Houweling, M., NO-VANS, de (1996). Ukuvezwa kwe-phosphatidliwayonethanolamine n-methyltransferase-2 ku-mCardle-Rh7777 Hepatoma amaseli kabusha kabusha ama-phosphatidylethanolanolanolamine kanye ne-triacyllysglycerol pools. I-Journal of Biological Chemistry, 271 (36), 21624-21631.
UHannun, Ya, & Obeid, LM (2012). Ama-ceramide amaningi. I-Journal of Biological Chemistry, 287 (23), 19060-19068.
UKornHuber, J., Medlin, A., Bleich, S., Jendrossek, v., Henlin, Henlin, G. (2005). Umsebenzi ophakeme we-acid spingemyelinase ngokudangala okukhulu. Ijenali yokudluliselwa kwe-neural, 112 (12), 15833-1590.
I-KRSTIC, D., kanye ne-kinsel, i. (2013). Ukuqondisa indlela yokuthola imali ephansi ye-alzheimer yesifo se-alzheimer esekwephuzile. Imvelo Ukubuyekezwa Neurology, 9 (1), 25-34.
Jiang, XC, LI, Z., & LIU, R. (2018). I-Andreotti, G, iphinde ibuyele ukuxhumana phakathi kwama-phospholipids, ukuvuvukala kanye ne-atherossteosis. I-Clinical Lipidology, 13, 15-17.
Hallill, B. (2007). Biochemistry of oxidative xity. Ukukhokhelwa kwe-Biochemical Society, 35 (5), 1147-1150.
I-Lattka, E. U-Illig, u-Illig, uT. Heinrich, J., & Koletzko, B. (2010). Ingabe ama-acid anamafutha obisini lwabantu avikelekile ekukhulupheleleni? I-International Journal of Ofesity, 34 (2), 157-163.
Cohn, JS, noKamili, A. (2010). Wat, E, no-Adeli, izindima ezivelayo ze-proprotein preprotease Subtisisin / Kexin Type 9 inhibition in Lipid Metabolism kanye ne-atherosserosis. Imibiko yamanje ye-atherossclerosis imibiko, 12 (4), 308-315.
UZeisel Sh. UCHOLONE: Iqhaza elibalulekile ngesikhathi sokuthuthuka kwe-fetus kanye nezidingo zokudla kubantu abadala. U-Annu Surver Fyow. 2006; 26: 229-50. I-DoI: 10.11146 / Annurev.nutr.26.061505.111156.
Liu l, geng j, srinivasarao m, et al. Phospholipid eicosapentaenoeonicid acid phospholipids ukuthuthukisa umsebenzi we-neurobehavioral kumagundane alandela ukulimala kobuchopho be-neonatal hypoxic-ischemic. Pediatr res. 2020; 88 (1): 73-82. Doi: 10.1038 / S41390-019-0633-8.
Garg r, singh r, Manchanda SC, Singla D. Iqhaza lezinhlelo zonoveli zokulethwa kwezidakamizwa ezisebenzisa ama-nanostars noma ama-narossondes. I-South Aff J Bot. 2021; 139 (1): 109-120. DOI: 10.1016 / J.Sajb.2021.01.023.
UKelley, isib, Albert, Ad, & Sullivan, Mo (2018). Ama-membrane lipids, ama-eicosanoids, kanye nokushintshana ngokuhlukahluka kwe-phospholipid, ama-prostaglandins kanye ne-nitric oxide. I-Handbook of Experimental Pharmacology, 233, 235-270.
UVan Meer, G., Voelker, Dr, & Feigenson, GW (2008). Ama-membrane lipids: lapho bakhona nokuthi baziphatha kanjani. Imvelo Ukubuyekezwa kwe-Molecular Cell Biology, 9 (2), 112-124.
IBABANIBA, N., Shambat, G., Marsac, P., & Cansell, M. (2019). Intuthuko ekuhlolweni kwezimboni zama-phospholipids. I-ChemPyyschem, 20 (14), 1776-1782.
Tortulin, VP (2005). Ukuthuthuka kwakamuva ngama-liposomes njengezithwali zemithi. Imvelo ibukeza ukutholakala kwezidakamizwa, 4 (2), 145-160.
UBrezesinski, G., Zhao, Y Gutberlet, T. (2021). Imihlangano yePhospholipid: I-topology ye-headgroup, ukushaja, nokuvumelana nezimo. Umbono wamanje ku-colloid & interface Science Science, 51, 81-93.
I-ABRA, RM, & Hunt, CA (2019). Ama-Liposomal Drug Delivery Systems: Ukubuyekezwa okuneminikelo evela kwi-biophysics. Ukubuyekezwa kwamakhemikhali, ngo-119 (10), 6287-6306.
Allen, TM, & Cullis, Pr (2013). Izinhlelo zokulethwa kwezidakamizwa ze-Liposomal: Kusuka kumqondo kuya kwizicelo zemitholampilo. Ukubuyekezwa okuthuthukile kwezidakamizwa, 65 (1), 36-48.
I-Vance Je, vence de. Phospholipid biosynthesis eMammalian cell. Biochem cell biol. 2004; 82 (1): 113-128. doi: 10.11139 / O03-073
UVan Meer G, Voelker Dr, Feigenson GW. Ama-membrane lipids: lapho bakhona nokuthi baziphatha kanjani. INat Rev Mol Relle Biol. 2008; 9 (2): 112-124. doi: 10.1038 / NRM2330
I-Boon J. Iqhaza lama-phospholipids ekusebenzeni kwamaprotheni alwelwe ulwelwesi. I-Biochim Biophys Acta. 2016; 1858 (10): 2256-2268. DOI: 10.1016 / J.Bbamem.2016.030
Isikhathi sePosi: DEC-21-2023
