I-Cepharanthine Powder Ehlanzekile Yemvelo
I-Cepharanthine Powder Ehlanzekile Yemveloiwuhlobo oluyimpuphu lwe-cephalanthine ehlanganisiwe, etholakala esitshalweni i-Stephania cephalantha. I-alkaloid yemvelo ye-bisbenzylisoquinoline futhi ibilokhu isetshenziswa ngokwesiko kwezokwelapha zaseShayina nezaseJapane ngenxa yezakhiwo zayo zemithi, okuhlanganisa imisebenzi ye-antioxidant, anti-inflammatory, immunomodulatory, antitumoral, kanye ne-antiviral.
Ngokwesimo se-COVID-19, i-cephalanthine ibonise umsebenzi othembisayo wokulwa ne-COVID-19. Ibonise ukuvimbela okukhulu kokuphindaphindana kwe-SARS-CoV-2 ngegciwane, igciwane elibangela i-COVID-19. Amanani e-IC50 kanye ne-IC90 e-cephalanthine ngokumelene ne-SARS-CoV-2 angama-1.90 µM kanye nama-4.46 µM, ngokulandelana.
Ngaphezu kwalokho, i-cephalanthine iboniswe ukuthi iguqula ukumelana nemithi eminingi okubangelwa yi-P-glycoprotein (P-gp) kumaseli e-K562 futhi ithuthukise ukuzwela kwemithi yokulwa nomdlavuza kumamodeli egundane le-xenograft. Iphinde ibonise imiphumela yokuvimbela kuma-enzyme e-cytochrome P450 esibindi somuntu njenge-CYP3A4, CYP2E1, kanye ne-CYP2C9.
Kuyindlela ehlanganisiwe yale nhlanganisela, engasetshenziswa ngezinhloso ezahlukene, okuhlanganisa ucwaningo, ukuthuthukiswa kwemithi, kanye nokwakheka kwayo.
Uhlobo lwempuphu luvumela ukuphathwa, ukukala, kanye nokuhlanganiswa kwe-cephalanthine kalula, okwenza kube lula ukusetshenziswa ezinhlotsheni ezahlukene. Lungasetshenziswa ekuthuthukiseni imithi, izithasiselo, noma ezinye izindlela zokwelapha ezisebenzisa izakhiwo zokwelapha ze-cephalanthine.
I-Cepharanthine Powder Ehlanzekile Yemvelongokuvamile itholakala ngezinqubo zokukhipha nokuhlanza ukuqinisekisa izinga eliphezulu lokuhlanzeka nekhwalithi. Lokhu kuqinisekisa ukuthi impuphu ayinazo izinto ezingcolile, ukungcola, noma ezinye izinto ezingathinta ukusebenza kwayo noma ukuphepha kwayo.
| Into | Imininingwane | Imiphumela Yokuhlolwa |
| Ukubukeka | Impuphu emhlophe, iphunga elingathathi hlangothi, i-hygroscopic kakhulu | Ukuhambisana |
| Ukuhlonza | I-TLC: Isixazululo esijwayelekile kanye nesisombululo sokuhlola indawo efanayo, i-RF | Ukuhambisana |
| Ukuhlolwa (Isisekelo Esomile) | 98.0%--102.0% | 98.1% |
| I-Optical Eqondile | -2.4°~ -2.8° | -2.71° |
| PH | 4.5~7.0 | 5.3 |
| Izinsimbi Ezisindayo (Njengo-Pb) | ≤10ppm | <10ppm |
| As | ≤1ppm | Akutholakalanga |
| Pb | ≤0.5ppm | Akutholakalanga |
| Cd | ≤1ppm | Akutholakalanga |
| Hg | ≤0.1ppm | Akutholakalanga |
| Into ehlobene | Indawo ayinkulu kunejwayelekile indawo yesisombululo | Akukho ndawo |
| Isinyibilikisi esisele | <0.5% | Imithetho |
| Okuqukethwe kwamanzi | <2% | 0.18% |
(1) I-Pure Natural Cepharanthine Powder itholakala emithonjeni yemvelo, ikakhulukazi isitshalo i-Stephania cephalantha Hayata.
(2) Luhlobo oluhlanganisiwe lwe-cephalanthine ehlanganisiwe, okuvumela ukuphathwa, ukukalwa, kanye nokuhlanganiswa okulula.
(3) Le mpuphu ifanelekela izinjongo ezahlukahlukene, okuhlanganisa ucwaningo, ukuthuthukiswa kwemithi, kanye nokwakheka kwayo.
(4) Idlula ezinqubweni zokukhipha nokuhlanza ukuqinisekisa ukuhlanzeka okuphezulu kanye nekhwalithi, okungenakungcola noma ukungcola.
(5) Ingasetshenziswa ekuthuthukiseni imithi, izithasiselo, noma ezinye izindlela zokusebenzisa izakhiwo zokwelapha ze-cephalanthine.
(1) I-Pure Natural Cepharanthine Powder iboniswe ukuthi inezakhiwo ezinamandla zokulwa ne-antioxidant, isusa ama-free radicals futhi inciphise ukucindezeleka kwe-oxidative.
(2) Ibonisa imiphumela yokulwa nokuvuvukala, okungasiza ekunciphiseni izimpawu ezihambisana nezimo ezihlobene nokuvuvukala.
(3) I-Cepharanthine ihlolwe ngenxa yomsebenzi wayo ongaba khona wokulwa namagciwane, ikhombisa ukusebenza kahle ngokumelene nezinhlobo ezahlukene zamagciwane kanye nesikhunta.
(4) Kungase kube nezakhiwo zokulwa namagciwane futhi kuye kwahlolwa ukuthi kungenzeka yini ukuthi ilwa namagciwane ngokumelene namagciwane athile.
(5) Kutholakale ukuthi i-Cepharanthine inemiphumela yokulawula amasosha omzimba, okungenzeka ithuthukise impendulo yamasosha omzimba.
(6) Izifundo ziphakamisa ukuthi ingaba nezakhiwo zokulwa nomdlavuza, ivimbele ukukhula nokusabalala kwamaseli omdlavuza ezinhlotsheni ezahlukene zomdlavuza.
(7) Kuye kwahlolwa ngezinzuzo zayo ezingaba khona zenhliziyo nemithambo yegazi, njengokuthuthukisa ukugeleza kwegazi nokusekela impilo yenhliziyo.
(8) I-Cepharanthine ingaba nemiphumela yokuvikela izinzwa, okungenzeka inikeze ukwesekwa ezimweni zezinzwa.
Ibonisa ithemba emkhakheni wezokwelapha isikhumba, okungenzeka ukuthi inezakhiwo zokuvikela isikhumba kanye nokwelapha amanxeba.
(1) Imboni yezemithi
(2) Izakhamzimba kanye nezithako zokudla
(3) Izimonyo nokunakekelwa kwesikhumba
(4) Imithi yendabuko
(5) Ucwaningo nentuthuko
(1) Ukutshalwa kwezitshalo:Izinto zokusetshenziswa, izitshalo ze-Stephania cephalantha, zitshalwa ezindaweni ezifanele zezolimo.
(2) Ukuvuna:Izitshalo ezivuthiwe zikhethwa ngesandla ngokucophelela ukuqinisekisa ikhwalithi.
(3) Ukomisa:Izitshalo ezivuniwe zomiswa kusetshenziswa izindlela zendabuko noma amasu esimanje okususa umswakama.
(4) Ukukhipha:Izinto zesitshalo ezomisiwe ziyagaywa zibe yimpuphu ecolekile bese zikhishwa kusetshenziswa izinyibilikisi ezifana ne-ethanol noma amanzi.
(5) Ukuhlunga:I-extract iyahlungwa ukuze kususwe ukungcola futhi kutholakale ikhambi elicacile.
(6) Ukugxila:I-filtrate igxilile ukuze kususwe i-solvent eyengeziwe futhi kwandiswe ukugcwala kwe-Cepharanthine.
(7) Ukuhlanzwa:Ukukhishwa okugxilile kudlula ezinqubweni zokuhlanzwa okwengeziwe njenge-chromatography noma i-crystallization ukuze kutholakale i-Cepharanthine emsulwa.
(8) Ukomisa:I-Cepharanthine ehlanziwe iyomiswa ukuze kususwe noma yimuphi umswakama osele.
(9) Ukufaka ufulawa:I-Cepharanthine eyomisiwe iyagaywa ibe yimpuphu ecolekile.
(10) Ukulawulwa kwekhwalithi:Impuphu ihlolwa kanzima ukuqinisekisa ukuthi ihlangabezana nezindinganiso zekhwalithi zokuhlanzeka, amandla kanye nokuphepha.
(11) Ukupakisha:Umkhiqizo wokugcina upakishwa ezitsheni ezingangeni moya ukuze kulondolozwe ikhwalithi yawo kanye nesikhathi sokuphila kwawo eshalofini.
(12) Isitoreji:Impuphu ye-Cepharanthine epakishiwe igcinwa ezimweni ezifanele ukuze ihlale izinzile futhi isebenza kahle.
Qaphela: Inqubo yokukhiqiza yangempela ingahluka kuye ngomkhiqizi kanye nezidingo ezithile.
Indawo Yokugcina: Gcina endaweni epholile, eyomile, nehlanzekile, Vikela emswakama nasekukhanyeni okuqondile.
Iphakheji Elikhulu: 25kg/isigubhu.
Isikhathi Sokuhola: Izinsuku eziyi-7 ngemuva kwe-oda lakho.
Impilo Yeshelufu: Iminyaka emi-2.
Phawula: Ukucaciswa okwenziwe ngezifiso nakho kungafinyelelwa.
20kg/isikhwama 500kg/iphalethi
Ukupakisha okuqinisiwe
Ukuphepha kwempahla
I-Express
Ngaphansi kwe-100kg, izinsuku ezi-3-5
Isevisi yokungena emnyango kulula ukuyithatha izimpahla
Ngasolwandle
Ngaphezulu kwama-300kg, cishe izinsuku ezingama-30
Kudingeka umthengisi wezinsizakalo zokukhishwa kwemvume ochwepheshe
Ngomoya
100kg-1000kg, Izinsuku ezi-5-7
Kudingeka umthengisi wezinsizakalo zokuhlanza ochwepheshe kusukela esikhumulweni sezindiza kuya esikhumulweni sezindiza
I-Cepharanthine Powder Ehlanzekile Yemveloiqinisekiswe ngesitifiketi se-ISO, isitifiketi se-HALAL, kanye nesitifiketi se-KOSHER.
Imiphumela emibi ye-Pure Natural Cepharanthine Powder ingahluka kumuntu nomuntu futhi ingase ingabi khona kuwo wonke umuntu. Eminye imiphumela emibi ebikiwe ihlanganisa:
Izinkinga Zesisu:Abanye abantu bangase babe nokungakhululeki kwesisu, njengokucanuzela kwenhliziyo, ubuhlungu besisu, uhudo, noma ukuqunjelwa.
Ukusabela Kokungezwani Nomzimba:Ezimweni ezingavamile, kungase kube nokusabela kokungezwani komzimba, okuholela ezimpawini ezifana nokuqubuka kwesikhumba, ukulunywa, ukuvuvukala, noma ubunzima bokuphefumula. Uma uhlangabezana nanoma yikuphi ukusabela kokungezwani komzimba, yeka ukusebenzisa bese ucela usizo lwezokwelapha ngokushesha.
Umfutho Wegazi Nezinga Lokushaya Kwenhliziyo:I-Cepharantine ingaba nomthelela ekucindezelweni kwegazi kanye nokushaya kwenhliziyo. Abantu abanezinkinga zenhliziyo noma labo abathatha imithi yokulawula umfutho wegazi kufanele baqaphele futhi baxhumane nochwepheshe wabo wezempilo ngaphambi kokusebenzisa i-Cepharantine.
Ukusebenzisana Nemithi:I-Cepharanthine ingase ihlangane nemithi ethile, njengemithi yokuvimbela ukugabha kwegazi noma imithi yokuvimbela ukugeleza kwegazi. Lokhu kusebenzisana kungathinta ukujiya kwegazi noma kwandise ingozi yokopha. Kubalulekile ukwazisa uchwepheshe wakho wezempilo ngayo yonke imithi oyithathayo ngaphambi kokusebenzisa i-Cepharanthine.
Eminye Imiphumela Engase Ibe Khona:Nakuba kunezifundo ezilinganiselwe ngemiphumela ethile emibi ye-Cepharanthine, abanye abasebenzisi babike ukuthi babhekene nokuphazamiseka kokulala, isiyezi, ikhanda elibuhlungu, noma izinguquko ekufiseni ukudla.
Kubalulekile ukuqaphela ukuthi imiphumela emibi engenhla ayiphelele, futhi okuhlangenwe nakho komuntu ngamunye kungahluka. Uma uhlangabezana nanoma yimiphi imiphumela emibi ekhathazayo noma eqhubekayo ngenkathi uthatha i-Cepharantine, kubalulekile ukufuna usizo lwezokwelapha nokubonisana nochwepheshe wezempilo.
