I-corydalis ekhipha i-tetrahydropatine (DL-THP)
I-TetrahyDropatine (thp), eyaziwa nangokuthi i-DL-THP, iCorydalin Hydrochloride, noma i-corydalin tube ekhishwe, i-complen ehlukaniswe njenge-isoquinoline alkaloid. Kukhishwe ku-tuber of the Chinese herb corydalis yanhusuo. I-THP iyinto engenamibala noma ephuzi ye-crystalline yento enokunambitheka okubabayo kanye nephuzu lokuncibilika lika-147-149 ° C. Kuyinto engabonakali emanzini kodwa ukuncibilika kakhulu ku-ether, chloroform, ne-ethanol. I-hydroclorloride yayo nosawoti we-sulfate bubleble emanzini.
I-THP ifundelwe imiphumela ehlukahlukene yekhemisi, kufaka phakathi i-analgesic yayo, i-anaroprotatic, i-antiptatective, adgregation, antiptelot, antitbemot, antibemor, kanye nezakhiwo ezilwa nokudla. Kukholakala ukuthi kudlale imiphumela yayo ye-analgesic ngokuguqula umsebenzi we-central dopamine receptor futhi ukhombise amathuba okuvikela ama-neurons ekulimaleni kwe-ischemic. Ngokwengeziwe, i-THP ikhombisile imiphumela yokuhlanganisa ama-antiplettet futhi iye yaphenywa ngamandla ayo ekwelapheni izilonda, kuvimbela ukukhula kwamaseli emithi, nokusiza ekujuleni kwezidakamizwa.
Sekukonke, i-TetrahyDropatine (DL-THP) iyingxenye enezici ezahlukahlukene zokhemisi futhi kube yisihloko socwaningo olunzulu lwezicelo zalo zokwelapha ezingaba khona. Ukuthola eminye imininingwane Ukuxhumanagrace@biowaycn.com.
Nazi izici zomkhiqizo weTetraHyDropatine (thp) kanye nezinzuzo zawo zezempilo:
1. Izakhiwo ze-analgesic:I-THP ikhombisa imiphumela ye-analgesic ngokuguqula umsebenzi we-central dopamine receptor, ukuhlinzeka ngokukhululeka kobuhlungu ngaphandle kwamandla amakhulu umlutha.
2. Imiphumela ye-NeuropTevect:I-THP ikhombise amathuba okuvikela ama-neurons ekulimaleni kwe-ischemic, enciphisa i-apoptosis ye-neuronal, kanye nokwehlisa amazinga ama-glutamate ebuchosheni, okungaba nomthelela ezingxenyeni zayo zezinzwa.
3. Ukuhlanganiswa kwe-antiplet:I-THP itholakele ukuthi ivimbela ukuhlanganiswa kwe-platelet, okungenzeka kunciphise ubungozi bokwakheka kwegazi kanye nemicimbi ehlobene nenhliziyo.
4. Isisulu sempilo ye-Grastric:I-THP ikhombisile imiphumela yokulwa nesilonda futhi ingasiza ekunciphiseni imfihlo ye-acid yesisu, ukuhlinzeka impumuzo kusuka ezilondeni zesisu kanye nezimo ezihlobene.
I-5. Umsebenzi ongaba khona we-antitumor:I-THP ikhombisile imiphumela ye-cytotoxic kumaseli we-tumor, ephakamisa indima enokwenzeka ekuvikeleni ukukhula kwezimila.
6. Izakhiwo zokulwa nokudla:I-THP ifundelwe amandla ayo ukunciphisa izimpawu zokuhoxa ezihambisana nomlutha we-opioid kanye nokuvuselela umlutha, ukunikela ekwelashweni kokudilizwa kanye nokubuyela emuva ekuvinjelweni.
Lezi zici zigqamisa izinzuzo zezempilo ezahlukahlukene kanye nezicelo ezingaba khona zokwelapha zeTetrahyDropatine (thp).
I-Tetrahydropydalin (DL-THP) ingeyakwa-Isoquinoline Alkalioids futhi iyi-alkaloid, ikakhulukazi kuhlobo lweCorydalis lucidum (yan hu suo), kodwa nakwezinye izitshalo ezinjengeStepania Rotunda. Lezi zitshalo zinokusetshenziswa kwendabuko emithini yamakhambi yaseChina.I-Corydalis iyisitshalo se-herbaceous esiseduze, esingama-10 kuye kwangama-20 cm, ngama-tubers ayindilinga. Iziqu zalo ezingenhla ezingenhla zifushane futhi zithambile, zinesilinganiso ngaphezulu kwesisekelo. Amaqabunga asemuva kanye namaqabunga e-cauline afanayo ngesimo, ngeziqu; Amaqabunga e-cauline ahlukile, anamaqabunga ama-2 no-3 ahlanganisiwe. Iqabunga lesibili livame ukuqhekeka ngokuphelele futhi libole kakhulu. Amaqabunga amancane angu-oblong, i-oval, noma i-oval. Ulayini, cishe ama-2 cm ubude, enobuhlakani noma obukhali obukhali kanye nemiphetho ecocekile. I-inflorescence yayo i-raceme-shaped, ngamaqabunga e-terminal noma aphambene; Amabhulukwe abanzi kakhulu; Izimbali zibomvu zibomvu futhi zikhule ngokuvundlile kuma-pedicel athambile, acishe abe ngu-6 mm ubude; ICalyx iwela kusenesikhathi; Ama-petals angu-4 kanti ama-whorls angaphandle angu-2 izingxenye zikhudlwana kancane, zinemiphetho epinki nesikhungo esiphuzi-nsomi. Kunengxenye eyodwa ephezulu, futhi umsila udlulela ku-spur ende. Ubude be-spur bubalelwa cishe ingxenye yobude obuphelele. Izingxenye ezi-2 zangaphakathi zincane kunezinhlaka ezi-2 zangaphandle. Isiphetho esiphezulu sibe nsomi futhi siphulukisiwe, futhi ingxenye engezansi ipinki; Ama-stamens angu-6, futhi ama-filaments axhumeke ezinyangeni ezimbili, ngalinye linama-anthers ama-3; I-ovary iyi-flat-cylindrical, isitayela sifushane futhi sincane, futhi ukubandlululwa kungu-2, njengebhabhathane elincane. Izithelo zalo ziyi-capsule. UCorydalis ukhiqizwa ikakhulukazi ezintabeni noma ezindaweni ezinotshani. Izindawo eziphambili ezikhiqiza zifaka uZhejiang, Hebei, Shandong, Jiangsu, nezinye izindawo.
| Ukuhlahlela | Ukucacisa |
| Ngalokho | Tetrahydropatine ≥98% |
| Ukubonakala | I-powder ekhanyayo ekhanyayo ku-powder emhlophe |
| Umlotha | ≤0.5% |
| Ubumanzi | ≤5.0% |
| Izibulala-zinambuzane | -Phikisayo |
| Izinsimbi ezisindayo | ≤10pppm |
| Pb | ≤2.0PPM |
| As | ≤2.0PPM |
| Iphunga | -Yisimilo |
| Usayizi wezinhlayiyana | I-100% nge-80 mesh |
| I-Microbiological: | |
| Ingqikithi yamabhaktheriya | ≤1000cFU / g |
| Isilingi mp3 | ≤100cFU / g |
| USalmgosella | -Phikisayo |
| Ikho eyizicaba | -Phikisayo |
Nayi izimboni zohlelo lokusebenza zomkhiqizo weTetrahyDropatine (THP):
1. Izemithi:I-THP isetshenziswa embonini yezemithi yokwakha imishanguzo yokuphathwa kwezinhlungu nezidakamizwa zezinhlungu.
2. I-NutriCeticals:I-THP isetshenziswa emkhakheni weNututical Conceutical for applements okuqondiswe kuyo usizi lokukhululeka kanye nokuxhaswa kwempilo yesisu.
3. I-biotechnology:I-THP ithola izinhlelo zokusebenza ku-biotechnology yokucwaninga ngezindlela zokwelapha ze-antipliplet kanye nama-adports angaba khona umdlavuza.
4. Ukunakekelwa Kwezempilo:I-THP ifakwa kwimikhiqizo yezokunakekelwa kwempilo yokuphatha umlutha kanye nokuhoxisa izimpawu ezihambisana ne-opioid nokusetshenziswa okuvuselelayo.
5. Ama-cosmeceuticals:I-THP ihlolwe kuma-cosmeceuticals ukuthola impilo engaba khona isikhumba nezinhlelo zokusebenza zokulwa nokuvuvukala.
Lezi zimboni zibonisa ukusetshenziswa okuhlukahlukene okungenzeka kwe-tetrahydropatine (thp) ekuthuthukisweni okuhlukahlukene komkhiqizo kanye nezimo zocwaningo.
Imikhiqizo yethu yenziwa kusetshenziswa izindlela zokulawula ikhwalithi eqinile futhi zinamathele kumazinga aphezulu ezinqubo zokukhiqiza. Sibeka phambili ukuphepha nekhwalithi yomkhiqizo wethu, ukuqinisekisa ukuthi ihlangabezana nezidingo zokulawula kanye nezitifiketi zezimboni. Lokhu kuzibophezela kwikhwalithi kuhlose ukusungula ukwethembana nokuzethemba ekuthembekeni komkhiqizo wethu. Inqubo yokukhiqiza ejwayelekile imi ngale ndlela elandelayo:
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