I-Corydalis Extract Tetrahydropalmatine (dl-THP)
I-Tetrahydropalmatine (THP), eyaziwa nangokuthi i-dl-THP, i-Corydalin hydrochloride, noma i-Corydalin Tube Extract, iyinhlanganisela ehlukaniswe njenge-isoquinoline alkaloid. Ikhishwa ku-tuber yesitshalo saseShayina i-Corydalis yanhusuo. I-THP iyinto ekristalu engenambala noma ephuzi ephuzi enokunambitheka okubabayo kancane kanye nephuzu lokuncibilika elingu-147-149°C. Ayincibiliki emanzini kodwa incibilika kakhulu ku-ether, chloroform, kanye ne-ethanol. Usawoti wayo we-hydrochloride kanye ne-sulfate uyancibilika emanzini.
I-THP ihlolwe ngemiphumela ehlukahlukene yezokwelapha, okuhlanganisa ukudambisa ubuhlungu, ukudambisa izinhlungu, ukuvikela imizwa, ukuhlanganisa ama-platelet, ukulwa nezilonda, ukulwa nomdlavuza, kanye nezakhiwo zokulwa nomlutha. Kukholakala ukuthi inemiphumela yayo yokudambisa ubuhlungu ngokushintsha umsebenzi we-central dopamine receptor futhi ibonise amandla okuvikela ama-neurons ekulimaleni kwe-ischemic. Ngaphezu kwalokho, i-THP ibonise imiphumela yokuhlanganisa ama-platelet futhi ihlolwe amandla ayo ekwelapheni izilonda, ukuvimbela ukukhula kwamaseli esimila, kanye nokusiza ekuluthweni yizidakamizwa.
Sekukonke, i-Tetrahydropalmatine (dl-THP) iyinhlanganisela enezakhiwo ezahlukahlukene zemithi futhi ibilokhu icwaningwa kabanzi ngezinhlelo zayo zokwelapha ezingaba khona. Ukuze uthole ulwazi olwengeziwe xhumana nathi.grace@biowaycn.com.
Nazi izici zomkhiqizo ze-Tetrahydropalmatine (THP) kanye nezinzuzo zazo zezempilo:
1. Izakhiwo Zokuhlunguphaza:I-THP ikhombisa imiphumela yokunciphisa ubuhlungu ngokushintsha umsebenzi we-central dopamine receptor, ihlinzeka ngokukhululeka ebuhlungwini ngaphandle kwamandla abalulekile okulutha.
2. Imiphumela Yokuvikela Izinzwa:I-THP ibonise amandla okuvikela ama-neurons ekulimaleni kwe-ischemic, ukunciphisa i-neuron apoptosis, kanye nokwehlisa amazinga e-glutamate ebuchosheni, okungase kube nomthelela ezimpahleni zawo zokuvikela ama-neuro.
3. Ukuhlanganiswa Kwe-Antiplatelet:Kutholakale ukuthi i-THP ivimbela ukuhlangana kwama-platelet, okungenzeka inciphise ingozi yokwakheka kwama-clot egazi kanye nemicimbi yenhliziyo ehlobene nayo.
4. Ukusekelwa Kwempilo Yesisu:I-THP ibonise imiphumela yokulwa nezilonda futhi ingasiza ekunciphiseni ukukhiqizwa kwe-asidi esiswini, inikeze impumuzo ezilondeni zesisu nasezimweni ezihlobene nazo.
5. Umsebenzi Ongaba Khona Wokulwa Nomdlavuza:I-THP ibonise imiphumela enobuthi kumaseli esimila, okuphakamisa indima engaba khona ekuvimbeleni ukukhula kwesimila.
6. Izakhiwo Zokulwa Nokulutha:I-THP ihlolwe ukuthi inamandla okunciphisa izimpawu zokuhoxa ezihambisana nokulutha kwe-opioid kanye nokuvuselela amandla, inikeza ithemba ekwelapheni ukulutha kanye nokuvimbela ukubuyela emuva.
Lezi zici ziqokomisa izinzuzo ezahlukene zezempilo kanye nokusetshenziswa okungenzeka kokwelapha kwe-Tetrahydropalmatine (THP).
I-Tetrahydropydalin (dl-THP) ingeyama-alkaloid e-isoquinoline futhi iyi-alkaloid, ikakhulukazi kuhlobo lwe-Corydalis lucidum (Yan Hu Suo), kodwa nakwezinye izitshalo ezifana ne-Stephania rotunda. Lezi zitshalo zisetshenziswa ngokwendabuko emithini yamakhambi aseShayina.I-Corydalis iyisitshalo esihlala isikhathi eside esinamaqabunga, esinobude obungu-10 kuya ku-20 cm, esinezimila eziyindilinga. Iziqu zayo ezingaphezulu komhlaba zimfushane futhi zincane, zinesilinganiso ngaphezu kwesisekelo. Amaqabunga aphansi namaqabunga e-cauline afana ngesimo, aneziqu; amaqabunga e-cauline ayashintshana, anamaqabunga amabili namathathu ahlanganisiwe. Iqabunga lesibili livame ukuhlukana ngokuphelele futhi linezimbobo ezijulile. Amaqabunga amancane ayindilinga, ayindilinga, noma ayindilinga. Aqondile, angaba ngu-2 cm ubude, ane-apex eqondile noma ebukhali kanye nemiphetho ecocekile. I-inflorescence yayo inomumo we-raceme, enamaqabunga aphelele noma aphambene; ama-bracts anombala obanzi we-lanceolate; izimbali zibomvu-onsomi futhi zikhula zivundlile kuma-pedicel amancane, angaba ngu-6 mm ubude; i-calyx iwa kusenesikhathi; amacembe angama-4 kanti ama-whorl angaphandle angama-2. Izingxenye zinkulu kancane, zinemiphetho epinki kanye nesikhungo esiluhlaza okwesibhakabhaka-onsomi. Kukhona ingxenye eyodwa ephezulu, futhi umsila udlulela e-spur ende. Ubude be-spur buhlanganisa cishe ingxenye yobude bonke. Izingxenye ezimbili zangaphakathi zincane kunezingxenye ezimbili zangaphandle. Ingxenye engenhla iluhlaza okwesibhakabhaka futhi iphilile, kanti ingxenye engezansi ipinki; Ama-stamens ayi-6, kanti imicu ixhunywe ezinqwabeni ezimbili, ngayinye inezinhlayiya ezintathu; i-ovary i-flat-cylindrical, isitayela sifushane futhi sincane, kanti i-stigma iyi-2, njengebhabhathane elincane. Isithelo sayo siyi-capsule. I-Corydalis ikhiqizwa kakhulu ezintabeni noma ezindaweni ezinotshani. Izindawo ezikhiqiza kakhulu zifaka phakathi i-Zhejiang, i-Hebei, i-Shandong, i-Jiangsu, nezinye izindawo.
| Ukuhlaziywa | Imininingwane |
| Ukuhlolwa | I-Tetrahydropalmatine ≥98% |
| Ukubukeka | Impuphu ephuzi kancane kuya kokumhlophe |
| Umlotha | ≤0.5% |
| Umswakama | ≤5.0% |
| Izibulala-zinambuzane | Okubi |
| Izinsimbi ezisindayo | ≤10ppm |
| Pb | ≤2.0ppm |
| As | ≤2.0ppm |
| Iphunga | Isici |
| Usayizi wezinhlayiya | I-mesh engu-100% kuya ku-80 |
| Izinto eziphilayo: | |
| Inani lamagciwane | ≤1000cfu/g |
| Isikhunta | ≤100cfu/g |
| I-Salmgosella | Okubi |
| I-Coli | Okubi |
Nazi izimboni zokusetshenziswa komkhiqizo zeTetrahydropalmatine (THP):
1. Imithi:I-THP isetshenziswa embonini yezemithi ekuthuthukiseni imithi yokulawula ubuhlungu kanye nemithi yokuvikela izinzwa.
2. Izakhamzimba:I-THP isetshenziswa embonini ye-nutraceutical ekwenzeni izithasiselo ezihlose ukuqeda ubuhlungu kanye nokusekelwa kwempilo yesisu.
3. I-Biotechnology:I-THP ithola izinhlelo zokusebenza ku-biotechnology zocwaningo mayelana nokwelashwa kwe-antiplatelet kanye nezinye izindlela zokwelapha umdlavuza ezingaba khona.
4. Ukunakekelwa Kwezempilo:I-THP ifakwa emikhiqizweni yokunakekelwa kwempilo yokulawula umlutha kanye nezimpawu zokuhoxa ezihlobene nokusetshenziswa kwe-opioid kanye nokuvuselela amandla.
5. Izinto Zokuhlobisa:I-THP ihlolwa kwezokwelapha ngezimonyo ukuze kutholakale ukuthi ingaba nempilo yesikhumba kanye nezindlela zokulwa nokuvuvukala.
Lezi zimboni zibonisa ukusetshenziswa okuhlukahlukene okungenzeka kwe-Tetrahydropalmatine (THP) ezimweni ezahlukene zokuthuthukiswa komkhiqizo kanye nocwaningo.
Imikhiqizo yethu ikhiqizwa kusetshenziswa izindlela zokulawula ikhwalithi eziqinile futhi ilandela amazinga aphezulu ezinqubo zokukhiqiza. Sibeka phambili ukuphepha nekhwalithi yomkhiqizo wethu, siqinisekisa ukuthi uhlangabezana nezidingo zomthetho kanye nezitifiketi zemboni. Lokhu kuzibophezela kwikhwalithi kuhlose ukwakha ukwethembana nokuqiniseka ekuthembekeni komkhiqizo wethu. Inqubo yokukhiqiza ejwayelekile imi kanje:
Isitoreji:Gcina endaweni epholile, eyomile, nehlanzekile, Vikela emswakama nasekukhanyeni okuqondile.
Iphakheji Eningi:20~25kg/isigubhu.
Isikhathi esiholayo:Izinsuku eziyi-7 ngemuva kwe-oda lakho.
Isikhathi Sokuphila Seshelufu:iminyaka engu-2.
Phawula:Imininingwane eyenziwe ngokwezifiso ingafinyelelwa.
I-Express
Ngaphansi kwe-100kg, izinsuku ezi-3-5
Isevisi yokungena emnyango kulula ukuyithatha izimpahla
Ngasolwandle
Ngaphezulu kwama-300kg, cishe izinsuku ezingama-30
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100kg-1000kg, Izinsuku ezi-5-7
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