I-Stephania Extract Cepharanthine Powder

Igama Lomkhiqizo: I-Stephania Japonica Extract
Umsuka wesiLatini: Stephania cephalantha Hayata(Stephania japonica (Thunb.) Miers)/ Stephania epigaea Lo/ Stephania yunnanensis HSLo.
Ukubukeka: Impushana Emhlophe, Empunga
Isithako Esisebenzayo: I-Cepharanthine 80% -99% HPLC
Ingxenye Esetshenzisiwe: I-Tuber / Umsuka
Isicelo: Imikhiqizo yezempilo
Iphoyinti lokuncibilika: 145-155 °
Ukujikeleza okuqondile: D20+277°(c=2inchloroform)
Indawo yokubilisa: 654.03°C (isilinganiso esinzima)
Ukuminyana:1.1761(isilinganiso esinzima)
Inkomba ye-Refractive:1.5300(isilinganiso)
Izimo zesitoreji:i-underinertgas(nitrogen noma i-Argon)ku-2-8°C
Ukunyibilika:I-Soluble ku-SO(35mg/mL) noma i-ethanol(20mg/mL)
I-acidity coefficient (pKa):7.61±0.20(Kubikezelwe)

Thumela i-imeyili kithi

Imininingwane Yomkhiqizo

Olunye Ulwazi

Omaka bomkhiqizo

Isingeniso Somkhiqizo

I-Stephania Extract Cepharanthine Powder iwuketshezi olutholakala ezigabeni zesitshalo i-Stephania cephalantha Hayata(Stephania japonica (Thunb.) Miers) noma i-Stephania epigaea Lo/ Stephania yunnanensis HSLo. I-Cepharanthine ingumkhiqizo wemvelo ohlukanisiwe nalesi sitshalo futhi ube yisihloko sezifundo ezihlukahlukene ngenxa yezakhiwo zayo zemithi ezingase zibe khona. Kutholwe ukuthi ikhombisa imisebenzi elwa ne-SARS-CoV-2, ekhombisa ukusebenza kahle ekucindezeleni ukwanda kwegciwane. Ukwengeza, i-Cepharanthine ibonise ikhono lokuhlehlisa ukumelana ne-P-glycoprotein (P-gp) -mediated multidrug kumaseli athile futhi ithuthukise ukuzwela kwama-anticancer agents kumamodeli wokuhlola. Ngaphezu kwalokho, kuboniswe ukuthi kunemiphumela evimbelayo esibindini somuntu se-cytochrome P450 enzymes CYP3A4, CYP2E1, ne-CYP2C9, futhi ihlotshaniswa nemiphumela ye-antitumor, anti-inflammatory, ne-antinociceptive.
Kafushane, i-Stephania Extract Cepharanthine Powder iwuhlobo oluyimpuphu lomkhiqizo wemvelo i-Cepharanthine etholakala esitshalweni se-Stephania cephalantha, esibonise amandla okusebenza okuhlukahlukene kwemithi.

Ukucaciswa(COA)

Umkhiqizo	I-Cepharanthine
I-CAS	481-49-2
Isivivinyo	80%~99%
Ukubukeka	Impushana emhlophe
Ukupakisha	1KG/Isikhwama seFoil
Into	Ukucaciswa
Ukubukeka	impushana emhlophe empunga, iphunga elingathathi hlangothi, i-hygroscopic kakhulu
Ukuhlonza	I-TLC: Isixazululo esijwayelekile nesixazululo sokuhlola indawo efanayo, i-RF
I-Assay (Isisekelo Esomile)	98.0%--102.0%
I-Specific Optical	-2.4°~ -2.8°
PH	4.5~7.0
Izinsimbi Ezisindayo (As Pb)	≤10ppm
As	≤1ppm
Pb	≤0.5ppm
Cd	≤1ppm
Hg	≤0.1ppm
Into ehlobene	Indawo ayinkulu kunesixazululo esijwayelekile
I-solvent eyinsalela	<0.5%
Okuqukethwe Amanzi	<2%

Izici Zomkhiqizo

I-Stephania Extract Cepharanthine Powder iwumkhiqizo wemvelo otholakala esitshalweni i-Stephania cephalantha Hayata. Kutholakale ukuthi inezinto eziningi ze-pharmacological, kuhlanganise:
1. Imisebenzi yokulwa ne-SARS-CoV-2
2. Imiphumela evimbelayo ekwandeni kwegciwane
3. Ukuguqulwa kokumelana ne-P-glycoprotein-mediated multidrug resistance
4. Ukuthuthukiswa kokuzwela kuma-anticancer agents
5. Imiphumela evimbelayo ku-cytochrome P450 yesibindi somuntu enzymes CYP3A4, CYP2E1, kanye ne-CYP2C9
6. I-Antitumor, anti-inflammatory, kanye nemiphumela ye-antinociceptive

Iyini i-Biosynthesis ye-Cepharanthine?

I-biosynthesis ye-cepharanthine ku-Stephania iqala ngokufiphala kwe-dopamine ne-4-hydroxyphenylacetaldehyde (4-HPAA, 5) nge-norcoclaurine synthase (NCS), ekhiqiza i-norcoclaurine.

Iyini i-Solubility ye-Cepharanthine?

I-Cepharanthine iyancibilika kuma-organic solvents afana ne-ethanol, i-DMSO, ne-dimethyl formamide (DMF). I-solubility ye-cepharanthine kulezi zincibilikisi cishe i-2, 5, ne-10 mg/ml, ngokulandelana. I-Cepharanthine iyancibilika kancane kumabhafa anamanzi.

Izinhlelo zokusebenza

Izimboni zokufaka isicelo ze-Stephania Extract Cepharanthine Powder zifaka i-Pharmaceutical, Nutraceutical, Biotechnology, kanye ne-Herbal Medicine, izicelo eziphambili zimi kanje:
Ukusetshenziswa okungaba khona emithi yokwelapha elwa namagciwane
Okungenzeka njenge-adjuvant ekwelapheni umdlavuza
Angase asetshenziswe ekwelapheni okulwa nokuvuvukala
Okungenzeka njenge-ejenti ye-analgesic
Lezi zinhlelo zokusebenza zigqamisa ukusetshenziswa okuhlukahlukene okungenzeka kwe-Stephania Extract Cepharanthine Powder ezimeni ezahlukahlukene zokwelapha.

Okwedlule: I-Gynostemma Leaf Extract powder

Olandelayo: I-Horse Chestnut Extract

Ukupakisha Nesevisi

Ukupakisha
* Isikhathi Sokulethwa: Cishe izinsuku zokusebenza ezi-3-5 ngemuva kokukhokha kwakho.
* Iphakheji: Kuzigubhu zefayibha ezinezikhwama zepulasitiki ezimbili ngaphakathi.
* Isisindo Net: 25kgs/drum, Isisindo Esiphelele: 28kgs/Drum
* Usayizi Wesigubhu & Nomthamo: ID42cm × H52cm, 0.08 m³/ Isigubhu
* Isitoreji: Kugcinwe endaweni eyomile nepholile, gwema ukukhanya okunamandla nokushisa.
* Impilo yeshelufu: Iminyaka emibili uma igcinwe kahle.

Ukuthumela ngomkhumbi
* I-DHL Express, i-FEDEX, ne-EMS ngamanani angaphansi kuka-50KG, ngokuvamile abizwa ngokuthi isevisi ye-DDU.
* Ukuthunyelwa kolwandle ngamanani angaphezu kwama-500 kg; futhi ukuthunyelwa ngomoya kuyatholakala nge-50 kg ngaphezulu.
* Ngemikhiqizo yenani eliphezulu, sicela ukhethe ukuthunyelwa ngomoya kanye ne-DHL express ukuze uphephe.
* Sicela uqinisekise ukuthi ungakwazi yini ukwenza imvume lapho izimpahla zifika kumasiko akho ngaphambi kokufaka i-oda. Kubathengi abavela eMexico, Turkey, Italy, Romania, Russia, nezinye izindawo ezikude.

Izindlela Zokukhokha Nezokudiliva

Express
Ngaphansi kwe-100kg, Izinsuku ezingu-3-5
Isevisi yendlu ngendlu kulula ukuthatha izimpahla

Ngasolwandle
Over 300kg, Cishe izinsuku ezingu-30
Kudingeka ichweba eliya esikhungweni somdayiseli wokuthola imvume

Ngomoya
100kg-1000kg, 5-7 Izinsuku
Kudingeka umthengisi wemvume yochwepheshe wesikhumulo sezindiza oya esikhumulweni sezindiza

Imininingwane Yokukhiqiza (Ishadi Eligelezayo)

1. Ukutshala Nokuvuna
2. Isizinda
3. Ukugxila kanye Nokuhlanzwa
4. Ukomisa
5. Ukumisa
6. Ukulawulwa Kwekhwalithi
7. Ukupakisha 8. Ukusabalalisa