I-Lycorine Hydrochloride
I-Lycorine hydrochloride iyimpuphu emhlophe kuya kwemhlophe etholakala kwi-alkaloid lycorine, etholakala ezitshalweni ze-Lycoris radiata (L'Her.), futhi ingeyomndeni wakwa-Amaryllidaceae. I-Lycorine hydrochloride inemiphumela ehlukahlukene yezokwelapha, okuhlanganisa ukulwa nomdlavuza, ukulwa nomdlavuza, ukulwa ne-HCV, ukulwa nokuvuvukala, ukulwa namagciwane, ukulwa namagciwane, ukulwa ne-angiogenesis, kanye nezakhiwo zokulwa nomalaleveva. Iyancibilika emanzini, i-DMSO, kanye ne-ethanol. Isakhiwo sayo samakhemikhali sibonakala ngohlaka oluyinkimbinkimbi lwe-steroidal olunokunambitheka okubabayo olunamaqembu amaningi asebenzayo, okuhlanganisa amaqembu e-hydroxyl nama-amino, okufaka isandla emisebenzini yayo yebhayoloji.
| Igama lomkhiqizo | I-Lycorine hydrochloride CAS:2188-68-3 | ||
| Umthombo Wezitshalo | I-Lycoris | ||
| Isimo sesitoreji | Gcina ngesiciko ekushiseni kwegumbi | Usuku lombiko | 2024.08.24 |
| Into | Okujwayelekile | Umphumela |
| Ubumsulwa(I-1965)I-HPLC） | I-Lycorine hydrochloride≥98% | 99.7% |
| Ukubukeka | Impuphu emhlophe qhwa | Ukuhambisana |
| Umlingiswa ongokomzimbaama-ics | ||
| Usayizi wezinhlayiya | I-NLT100% 80I-Mesh | Ukuhambisana |
| Ukulahlekelwa ekomiseni | ≤1.0% | 1.8% |
| Okunzima insimbi | ||
| Izinsimbi eziphelele | ≤10.0ppm | Ukuhambisana |
| Umholi | ≤2.0ppm | Ukuhambisana |
| I-Mercury | ≤1.0ppm | Ukuhambisana |
| I-Cadmium | ≤0.5ppm | Ukuhambisana |
| I-microorganism | ||
| Inani eliphelele lamagciwane | ≤1000cfu/g | Ukuhambisana |
| Imvubelo | ≤100cfu/g | Ukuhambisana |
| I-Escherichia coli | Akufakiwe | Akutholakalanga |
| I-Salmonella | Akufakiwe | Akutholakalanga |
| I-Staphylococcus | Akufakiwe | Akutholakalanga |
| Iziphetho | Abafanelekile | |
Izici:
(1) Ubumsulwa Obuphezulu:Umkhiqizo wethu ucutshungulwa ngokucophelela ukuqinisekisa izinga eliphezulu lokuhlanzeka, okubalulekile ekusebenzeni kahle nasekuphepheni kwawo ezinhlotsheni ezahlukene zokusebenza.
(2) Izakhiwo Zokulwa Nomdlavuza:Kubonise imiphumela ebalulekile yokulwa nomdlavuza ngokumelene nezinhlobo ezahlukene zomdlavuza, kokubili ngaphakathi kwesibeletho kanye nangaphakathi komzimba, ngezindlela ezifana nokukhuthaza ukumiswa komjikelezo weseli, ukuvusa i-apoptosis, kanye nokuvimbela i-angiogenesis.
(3) Isenzo Esiqondiswe Kaningi:Kukholakala ukuthi i-Lycorine hydrochloride isebenzisana nezinhloso eziningi zama-molecule, inikeza ukusebenza kahle kwe-spectrum ngokumelene namaseli omdlavuza.
(4) Ubuthi Obuphansi:Ibonisa ubuthi obuphansi kumaseli ajwayelekile, okuyisici esibalulekile ekusetshenzisweni kwayo njenge-ejenti yokwelapha.
(5) Iphrofayili Ye-Pharmacokinetic:Lo mkhiqizo uhlolisiswe nge-pharmacokinetics yawo, ubonisa ukumuncwa okusheshayo kanye nokukhishwa okusheshayo ku-plasma, okubalulekile ekulinganisweni nasekuhleleni ukwelashwa.
(6) Imiphumela Yokubambisana:I-Lycorine hydrochloride ibonise imiphumela ethuthukisiwe uma isetshenziswa kanye neminye imithi, okungaba wusizo ekunqobeni ukumelana nemithi kanye nokuthuthukisa imiphumela yokwelashwa.
(7) Okusekelwa Ucwaningo:Lo mkhiqizo usekelwa ucwaningo olunzulu, olunikeza isisekelo esiqinile sokusetshenziswa kwawo ekuthuthukisweni kwemithi kanye nezicelo zezokwelapha.
(8) Ukuqinisekiswa Kwekhwalithi:Izindlela zokulawula ikhwalithi eqinile zikhona kuyo yonke inqubo yokukhiqiza ukuqinisekisa ukuhambisana nokuthembeka komkhiqizo.
(9) Izicelo Ezihlukahlukene:Ifanele ukusetshenziswa ocwaningweni nasekuthuthukisweni kwezicelo zemithi, okuhlanganisa ukutholakala kwemithi kanye nokuthuthukiswa kokwelashwa komdlavuza.
(10) Ukuthobela imithetho:Kwenziwe ngokulandela amazinga e-GMP ukuqinisekisa ukuphepha nokusebenza kahle komkhiqizo.
(1) Imboni yezemithi:I-Lycorine hydrochloride isetshenziswa ekwakhiweni kwemithi yokulwa namagciwane kanye nemithi yokulwa nomdlavuza.
(2) Imboni ye-Biotechnology:Isetshenziswa ocwaningweni nasekuthuthukisweni kwemithi emisha yokwelapha kanye nezindlela zokwenziwa kwemithi.
(3) Ucwaningo lomkhiqizo wemvelo:I-Lycorine hydrochloride icwaningwa ngezinzuzo zayo zezempilo kanye nezakhiwo zayo zokwelapha.
(4) Imboni yamakhemikhali:Ingasetshenziswa njenge-chemical intermediate ekuhlanganisweni kwamanye amakhemikhali.
(5) Imboni yezolimo:I-Lycorine hydrochloride iye yaphenywa ukuthi inamandla kangakanani njengomuthi wokubulala izinambuzane wemvelo kanye nokulawula ukukhula kwezitshalo.
Inqubo yokukhipha i-lycorine hydrochloride ivame ukufaka izinyathelo ezilandelayo ezibalulekile ukuqinisekisa ubumsulwa be-solvent nokuthuthukisa izinga lokululama:
(1) Ukukhethwa kwezinto ezingavuthiwe kanye nokwelashwa kwangaphambi kwesikhathi:Khetha izinto zokusetshenziswa zezitshalo ze-Amaryllidaceae ezifanele, njengezibani ze-Amaryllis, bese uzigeza, uzomise bese uzichoboza ukuqinisekisa ubumsulwa bezinto zokusetshenziswa bese ubeka isisekelo sokukhishwa okulandelayo.
(2)Ukwelashwa kwangaphambili kwe-enzyme ehlanganisiwe:Sebenzisa ama-enzyme ayinkimbinkimbi (njenge-cellulase ne-pectinase) ukuze ulungise izinto zokusetshenziswa ezichotshoziwe kusengaphambili ukuze ubolise izindonga zamaseli ezitshalo futhi uthuthukise ukusebenza kahle kokukhipha okulandelayo.
(3)Nciphisa i-hydrochloric acid leaching:Hlanganisa izinto zokusetshenziswa ezilungisiwe kusengaphambili nesisombululo se-hydrochloric acid esincibilikisiwe ukuze kukhishwe i-lycorine. Ukusetshenziswa kwe-hydrochloric acid kusiza ukwandisa ukuncibilika kwe-lycorine, ngaleyo ndlela kuthuthukiswe ukusebenza kahle kokukhipha.
(4)Ukukhishwa okusizwa yi-Ultrasonic:Ukusetshenziswa kobuchwepheshe bokukhipha obusizwa yi-ultrasonic kungasheshisa inqubo yokuncibilikisa i-lycorine ku-solvent futhi kuthuthukise ukusebenza kahle kokukhipha kanye nobumsulwa.
(5)Ukukhishwa kwe-chloroform:Ukukhipha kwenziwa ngezinyibilikisi eziphilayo ezifana ne-chloroform, bese i-lycorine idluliselwa kusuka esigabeni samanzi iye esigabeni sezinto eziphilayo ukuze kuhlanzwe kakhulu inhlanganisela eqondiwe.
(6)Ukubuyiselwa kwe-solvent:Ngemva kwenqubo yokukhipha, i-solvent itholakala ngokuhwamuka noma ngokuhluzwa ukuze kuncishiswe ukusetshenziswa kwe-solvent futhi kuthuthukiswe ukonga.
(7)Ukuhlanzwa nokomiswa:Ngezinyathelo ezifanele zokuhlanza nokomisa, kutholakala i-lycorine hydrochloride powder emsulwa.
Kuyo yonke inqubo yokukhipha, ukulawula ukukhethwa kwesinyibilikisi, izimo zokukhipha (njengenani le-pH, izinga lokushisa, nesikhathi), kanye nezinyathelo zokuhlanza ezilandelayo kuyisihluthulelo sokuqinisekisa ubumsulwa besinyibilikisi nokuthuthukisa izinga lokululama. Ukusetshenziswa kwemishini yesimanje yokukhipha nokuhlanza, njenge-ultrasonic extractors kanye nezinhlelo ze-high-performance liquid chromatography (HPLC), nakho kusiza ekuthuthukiseni ukusebenza kahle kokukhipha kanye nekhwalithi yomkhiqizo.
Indawo Yokugcina: Gcina endaweni epholile, eyomile, nehlanzekile, Vikela emswakama nasekukhanyeni okuqondile.
Iphakheji Elikhulu: 25kg/isigubhu.
Isikhathi Sokuhola: Izinsuku eziyi-7 ngemuva kwe-oda lakho.
Impilo Yeshelufu: Iminyaka emi-2.
Phawula: Ukucaciswa okwenziwe ngezifiso nakho kungafinyelelwa.
I-Express
Ngaphansi kwe-100kg, izinsuku ezi-3-5
Isevisi yokungena emnyango kulula ukuyithatha izimpahla
Ngasolwandle
Ngaphezulu kwama-300kg, cishe izinsuku ezingama-30
Kudingeka umthengisi wezinsizakalo zokukhishwa kwemvume ochwepheshe
Ngomoya
100kg-1000kg, Izinsuku ezi-5-7
Kudingeka umthengisi wezinsizakalo zokuhlanza ochwepheshe kusukela esikhumulweni sezindiza kuya esikhumulweni sezindiza
I-Bioway Organic ithole izitifiketi ze-USDA kanye ne-EU organic, i-BRC, i-ISO, i-HALAL, i-KOSHER, kanye ne-HACCP.
I-Lycorine iyi-alkaloid yemvelo engatholakala ezitshalweni eziningana, ikakhulukazi emndenini we-Amaryllidaceae. Nazi ezinye izitshalo ezaziwa ngokuqukethe i-lycorine:
I-Lycoris radiata(eyaziwa nangokuthi i-red spider lily noma i-manjushage) iyikhambi lendabuko laseShayina eliqukethe i-lycorine.
I-Leucojum aestivum(iqhwa lasehlobo), liyaziwa nangokuthi liqukethe i-lycorine.
Ungernia sewertzowiiesinye isitshalo esivela emndenini we-Amaryllidaceae okubikwa ukuthi siqukethe i-lycorine.
I-Hippeastrum hybrid (i-Easter lily)kanye nezinye izitshalo ezihlobene ne-Amaryllidaceae ziyimithombo eyaziwayo ye-lycorine.
Lezi zitshalo zisakazeke kabanzi ezindaweni ezishisayo nezishisayo emhlabeni wonke futhi zinomlando omude wokusetshenziswa kwezokwelapha zendabuko. Ukuba khona kwe-lycorine kulezi zitshalo kube yindaba yocwaningo ngenxa yezakhiwo zayo ezingaba khona kwezokwelapha, okuhlanganisa nemiphumela yayo ebalulekile yokulwa nomdlavuza njengoba kuboniswe ezifundweni ezahlukahlukene.
I-Lycorine iyi-alkaloid yemvelo enemiphumela eminingi yezokwelapha, okuhlanganisa nokusetshenziswa kwayo okungenzeka ekwelapheni umdlavuza. Nakuba ibonise imiphumela ethembisayo ezifundweni ezahlukahlukene, kuneminye imiphumela emibi ebikiwe kanye nezinto ezicatshangelwayo ezihlobene nokusetshenziswa kwayo:
Ubuthi Obuphansi: I-Lycorine kanye nosawoti wayo we-hydrochloride ngokuvamile ibonisa ubuthi obuphansi, okuyisici esihle ekusetshenzisweni kwemitholampilo. Kuye kwabonakala kunemiphumela emibi emincane kakhulu kumaseli omuntu ajwayelekile kanye namagundane anempilo, okuphakamisa izinga elithile lokukhetha kwamaseli omdlavuza kunezicubu ezivamile.
Imiphumela Yesikhashana Yokuthuthumela: Ukucanuzela kwesikhashana nokuhlanza kuye kwabonakala ngemuva kokufakwa ngaphansi kwesikhumba noma ngemithambo ye-lycorine hydrochloride, ngokuvamile kuncipha zingakapheli amahora angu-2.5 ngaphandle kokuthinta ukuphepha kwamakhemikhali noma kwe-hematological.
Akukho Ukuhlanganiswa Kwezinzwa Ezingasebenzi: Izifundo zibonise ukuthi imithamo elandelanayo ye-lycorine ayithinti ukuhlanganiswa kwemisipha emagundwini, njengoba kuhlolwe ukuhlolwa kwe-rotarod, okubonisa ukuthi ayiholeli emiphumeleni emibi yesistimu yezinzwa ephakathi (CNS) ehlobene nokulawulwa kwemisipha.
Umthelela Emsebenzini Wokuhamba Okuzenzakalelayo: Ngomthamo ongu-30 mg/kg, i-lycorine ibonwe iphazamisa umsebenzi wokuhamba okuzenzakalelayo emagundwini, njengoba kuboniswe ukwehla kokuziphatha kokukhulisa kanye nokwanda kokungakwazi ukuhamba.
Ukuziphatha Okuvamile kanye Nenhlalakahle: Umthamo we-10 mg/kg we-lycorine awuzange uphazamise ukuziphatha okuvamile kanye nenhlalakahle yamagundane, okuphakamisa ukuthi lokhu kungaba umthamo ofanele kakhulu wokuhlolwa kokusebenza kahle kokwelapha esikhathini esizayo.
Akukho Imiphumela Emibi Ebalulekile Esisindweni Somzimba noma Esimweni Sempilo: Ukuphathwa kwe-lycorine ne-lycorine hydrochloride akuzange kubangele imiphumela emibi ebonakalayo esisindweni somzimba noma esimweni sempilo iyonke kumamodeli amagundane aphethe umdlavuza.
Kubalulekile ukuqaphela ukuthi yize i-lycorine ibonise amandla okuhlolwa kwangaphambi kokwelashwa, ukuhlolwa kobuthi besikhathi eside kusashoda. Ucwaningo olwengeziwe luyadingeka ukuze kuqondwe ngokugcwele iphrofayili yayo yokuphepha, ikakhulukazi ekusetshenzisweni kwesikhathi eside nasezindaweni zomtholampilo. Imiphumela emibi kanye nokuphepha kwe-lycorine kungahluka kuye ngomthamo, indlela yokuphathwa, kanye nezici zesiguli ngasinye. Njalo xhumana nochwepheshe wezempilo ngaphambi kokucabangela ukusebenzisa noma yisiphi isithasiselo esisha noma ukwelashwa.
