I-Pure Methyltetrahydrofolate Calcium (5MTHF-Ca)
I-Pure Methyltetrahydrofolate Calcium (5-MTHF-Ca) iwuhlobo lwe-folate olutholakala kakhulu nge-bioavailable futhi lungasetshenziswa kalula ngumzimba.Iwusawoti we-calcium we-methyltetrahydrofolate, okuwuhlobo olusebenzayo lwe-folate emzimbeni.I-Folate iwuvithamini B obalulekile odlala indima ebalulekile ezinqubweni ezihlukahlukene zamaselula, okuhlanganisa ukuhlanganiswa kwe-DNA, ukukhiqizwa kwamangqamuzana abomvu egazi, nokusebenza kwesimiso sezinzwa.
I-MTHF-Ca ivamise ukusetshenziswa njengesithasiselo sokudla ukusekela amazinga e-folate kubantu okungenzeka babe nobunzima bokugaya noma ukumunca uhlobo lokwenziwa lwe-folic acid etholakala ekudleni okuqinisiwe nasezithanjeni.Kuzuzisa kakhulu kubantu abanezinguquko ezithile zofuzo ezingase ziphazamise i-folate metabolism.
Ukwengeza nge-MTHF-Ca kungasiza ukusekela impilo nokuphila kahle iyonke, ikakhulukazi ezindaweni ezifana nempilo yenhliziyo nemithambo yegazi, ukuthuthukiswa kweshubhu le-neural ngesikhathi sokukhulelwa, ukusebenza kwengqondo, nokulawulwa kwemizwelo.Kubalulekile ukuqaphela ukuthi i-MTHF-Ca kufanele isetshenziswe ngaphansi kokuqondisa kochwepheshe bezempilo, ikakhulukazi kubantu abanezimo ezithile zezokwelapha noma labo abaphuza imithi ethile.
| Igama lomkhiqizo: | I-L-5-Methyltetrahydrofolate calcium |
| Omqondofana: | 6S-5-Methyltetrahydrofolate calcium;I-Calcium L-5-Methyltetrahydrofolate;Levomefolate calcium |
| I-Molecular Formula: | I-C20H23CaN7O6 |
| Isisindo se-Molecular: | 497.52 |
| Inombolo ye-CAS: | 151533-22-1 |
| Okuqukethwe: | ≥ 95.00% nge-HPLC |
| Ukubukeka: | Impushana eyikristale emhlophe ukuya kokuphuzi |
| Izwe azalelwe kulo: | China |
| Iphakheji: | 20kg/isigubhu |
| Impilo yeshelufu: | Izinyanga ezingama-24 |
| Isitoreji: | Gcina endaweni epholile futhi eyomile. |
| Izinto | Imininingwane | Imiphumela |
| Ukubukeka | Impushana emhlophe noma emhlophe | Qinisekisa |
| Ukuhlonza | Okuhle | Qinisekisa |
| I-calcium | 7.0%-8.5% | 8.4% |
| I-D-5-Methylfolate | ≤1.0 | Ayitholakali |
| Izinsalela ekushiseni | ≤0.5% | 0.01% |
| Amanzi | ≤17.0% | 13.5% |
| I-Assay(HPLC) | 95.0%-102.0% | 99.5% |
| Umlotha | ≤0.1% | 0.05% |
| Insimbi Enzima | ≤20 ppm | Qinisekisa |
| Inani Lepuleti Eliphelele | ≤1000cfu/g | Ufanelekile |
| Imvubelo nesikhunta | ≤100cfu/g | Ufanelekile |
| E.coil | Okubi | Okubi |
| I-Salmonella | Okubi | Okubi |
I-bioavailability ephezulu:I-MTHF-Ca iwuhlobo lwe-folate olutholakala kakhulu nge-bioavailable, okusho ukuthi lungamuncwa kalula futhi lusetshenziswe umzimba.Lokhu kubalulekile ngoba abanye abantu bangase babe nobunzima ekuguquleni i-folic acid yokwenziwa ibe yisimo sayo esisebenzayo.
Ifomu elisebenzayo le-folate:I-MTHF-Ca iwuhlobo olusebenzayo lwe-folate, eyaziwa ngokuthi i-methyltetrahydrofolate.Leli fomu lisetshenziswa kalula ngumzimba futhi alidingi izinqubo zokuguqula ezengeziwe.
I-Calcium Salt:I-MTHF-Ca ingusawoti we-calcium, okusho ukuthi iboshelwe ku-calcium.Lokhu kunikeza inzuzo eyengeziwe ye-calcium supplementation kanye nokusekelwa kwe-folate.I-calcium ibalulekile empilweni yamathambo, ukusebenza kwemisipha, ukudluliswa kwemizwa, neminye imisebenzi yomzimba.
Ifanele abantu abanezinhlobo ezithile zofuzo:I-MTHF-Ca inenzuzo ikakhulukazi kubantu abanezinguquko ezithile zofuzo ezingase ziphazamise i-folate metabolism.Lokhu kuhlukahluka kwezakhi zofuzo kungathinta ikhono lomzimba lokuguqula i-folic acid ibe ifomu layo elisebenzayo, okwenza ukufakwa kwe-folate esebenzayo kudingeke.
Isekela izici ezihlukahlukene zempilo:Ukwengezwa kwe-MTHF-Ca kungasekela impilo nokuphila kahle iyonke.Inenzuzo ikakhulukazi empilweni yenhliziyo nemithambo yegazi, ukuthuthukiswa kweshubhu le-neural ngesikhathi sokukhulelwa, ukusebenza kwengqondo, nokulawulwa kwemizwelo.
I-Pure Methyltetrahydrofolate Calcium (MTHF-Ca) inikeza izinzuzo eziningi zezempilo:
Ukwesekwa kwe-Folate metabolism:I-MTHF-Ca iwuhlobo olutholakala nge-bioavailable kakhulu futhi olusebenzayo lwe-folate.Kuyasiza ukusekela umzimba we-folate metabolism, obalulekile ekuhlanganiseni kwe-DNA, ukukhiqizwa kwamangqamuzana abomvu egazi, nokusebenza kwawo wonke amaseli.
Impilo yenhliziyo nemithambo yegazi:Amazinga anele e-folate abalulekile empilweni yenhliziyo nemithambo yegazi.I-MTHF-Ca supplementation ingasiza ekunciphiseni amazinga e-homocysteine, i-amino acid okuthi, lapho iphakanyisiwe, ihlotshaniswe nengozi eyengeziwe yesifo senhliziyo.
Ukwesekwa kokukhulelwa:I-MTHF-Ca ibalulekile ngesikhathi sokukhulelwa, njengoba isiza ukuvimbela ukukhubazeka kwe-neural tube ekukhuleni kwengane.Kunconywa kwabesifazane abaneminyaka yobudala ukuze baqinisekise ukuthi banamazinga anele e-folate, ikakhulukazi ngesikhathi sokuqala sokukhulelwa.
Ukulawulwa kwemizwa:I-Folate idlala indima ebalulekile ku-neurotransmitter synthesis.Amazinga e-folate anele asekela ukukhiqizwa kwe-serotonin, i-dopamine, ne-norepinephrine, ebalulekile ekulawuleni imizwa.Ukwengezwa kwe-MTHF-Ca kungase kube yinzuzo kubantu abanokuphazamiseka kwemizwa, njengokucindezeleka.
Umsebenzi wokuqonda:I-Folate ibalulekile ekusebenzeni kwengqondo nempilo yobuchopho.Ukwengezwa kwe-MTHF-Ca kungase kusekele inkumbulo, ukugxilisa ingqondo, nokusebenza kwengqondo okuphelele, ikakhulukazi kubantu abadala asebekhulile.
Ukwesekwa kokudla okunomsoco:Ukwengezwa kwe-MTHF-Ca kungaba yinzuzo kubantu abanezinguquko zofuzo ezithinta i-folate metabolism.Laba bantu bangase babe nobunzima bokuguqula i-folic acid yokwenziwa ibe yisimo sayo esisebenzayo.I-MTHF-Ca inikeza uhlobo olusebenzayo lwe-folate ngokuqondile, idlula noma yiziphi izinkinga zokuguqulwa.
Ama-Nutraceuticals kanye nezithako zokudla:I-MTHF-Ca ivamise ukusetshenziswa njengesithako esibalulekile ezithasiselweni zokudla okunomsoco kanye nama-nutraceuticals.Inikeza uhlobo lwe-folate olutholakala kakhulu nge-bioavailable, olunikeza izinzuzo eziningi zezempilo, njengoba kushiwo ngaphambili.
Ukuqinisa ukudla neziphuzo:I-MTHF-Ca ingafakwa emikhiqizweni yokudla nesiphuzo ukuze iqinise nge-folate.Lokhu kubaluleke kakhulu emikhiqizweni ebhekelela abantu abanokusilela kwe-folate noma ukwanda kwezidingo ze-folate, njengabesifazane abakhulelwe noma abantu abanezimo ezithile zempilo.
Ukwakhiwa kwemithi:I-MTHF-Ca ingasetshenziswa ekwenziweni kwemithi njengesithako esisebenzayo.Ingase isetshenziswe emithini eqondiswe ezimeni ezithile ezihlobene nokushoda kwe-folate noma ukonakala kwe-folate metabolism, njenge-anemia noma ukuphazamiseka okuthile kofuzo.
Ukunakekelwa komuntu siqu kanye nezimonyo:I-MTHF-Ca kwesinye isikhathi ifakwa emikhiqizweni yokunakekelwa komuntu siqu nezimonyo ngenxa yezinzuzo zayo ezingaba khona empilweni yesikhumba.I-Folate ibandakanyeka ezinqubweni ezihlukahlukene zamangqamuzana esikhumba futhi ingaba nomthelela empilweni nasekubukekeni kwayo yonke.
Ukudla kwezilwane:I-MTHF-Ca ingabuye ifakwe ekudleni kwezilwane ukwengeza izilwane nge-folate.Lokhu kubaluleke kakhulu ezimbonini zemfuyo nezinkukhu, lapho kubalulekile ukuqinisekisa ukudla okwanele ukuze kukhule kahle kanye nempilo.
Lezi zinkambu zohlelo lokusebenza zigqamisa ukuguquguquka kwe-MTHF-Ca kanye nokusetshenziswa kwayo okungenzeka ezimbonini ezahlukahlukene ukubhekana nokukhathazeka kwezempilo okuhlobene ne-folate kanye nezidingo zokudla okunomsoco.Kodwa-ke, kubalulekile ukulandela imihlahlandlela efanele yemithamo futhi uxhumane nochwepheshe lapho ufaka i-MTHF-Ca kunoma yimuphi umkhiqizo noma ukwakhiwa.
Ukuthola izinto zokusetshenziswa:Inqubo iqala ngokutholwa kwezinto ezingavuthiwe zekhwalithi ephezulu.Izinto zokusetshenziswa eziyisisekelo ezidingekayo ekukhiqizeni i-MTHF-Ca yi-folic acid nosawoti we-calcium.
Ukuguqulwa kwe-folic acid ku-5,10-Methylenetetrahydrofolate (5,10-MTHF):I-Folic acid iguqulwa ibe yi-5,10-MTHF ngenqubo yokunciphisa.Lesi sinyathelo ngokuvamile sihilela ukusetshenziswa kwama-ejenti okunciphisa njenge-sodium borohydride noma amanye ama-catalysts afanelekile.
Ukuguqulwa kwe-5,10-MTHF ukuze i-MTHF-Ca:I-5,10-MTHF iphinde iphendule ngosawoti we-calcium ofanele, njenge-calcium hydroxide noma i-calcium carbonate, ukuze yakhe i-Methyltetrahydrofolate Calcium (MTHF-Ca).Le nqubo ihlanganisa ukuxuba ama-reactants futhi uwavumele ukuthi asabele ngaphansi kwezimo ezilawulwayo, okuhlanganisa izinga lokushisa, i-pH, nesikhathi sokuphendula.
Ukuhlanzwa nokuhlunga:Ngemuva kokusabela, isixazululo se-MTHF-Ca singena ezinqubweni zokuhlanza ezifana nokuhlunga, i-centrifugation, noma amanye amasu okuhlukanisa ukuze kususwe ukungcola kanye nemikhiqizo engase yakheke ngesikhathi sokusabela.
Ukomisa nokuqinisa:Isixazululo esihlanziwe se-MTHF-Ca sibe sesiphinde sicutshungulwa ukuze kususwe umswakama oweqile futhi kuqiniswe umkhiqizo wokugcina.Lokhu kungafezwa ngamasu anjengokomisa isifutho noma ukomisa iqhwa, kuye ngefomu lomkhiqizo olifunayo.
Ukulawulwa kwekhwalithi nokuhlola:Umkhiqizo wokugcina we-MTHF-Ca ungaphansi kwezinyathelo eziqinile zokulawula ikhwalithi ukuze kuqinisekiswe ukuhlanzeka kwawo, ukuzinza, nokuhambisana nezindinganiso zekhwalithi ezishiwo.Lokhu kungase kuhlanganise ukuhlolwa kokungcola, amandla, neminye imingcele efanele.
Ukupakisha nokugcina:I-MTHF-Ca ifakwe ezitsheni ezifanele, iqinisekisa izimo zokulebula ezifanele kanye nezimo zokugcina ukugcina ubuqotho nokuzinza kwayo.Ivamise ukugcinwa endaweni eyomile, epholile kude nelanga eliqondile.
Isitoreji: Gcina endaweni epholile, eyomile, nehlanzekile, Vikela kumswakama nokukhanya okuqondile.
Iphakethe lenqwaba: 25kg / isigubhu.
Isikhathi Sokuhola: Izinsuku eziyi-7 ngemuva kwe-oda lakho.
Impilo yeshelufu: iminyaka emi-2.
Phawula: Ukucaciswa okwenziwe ngezifiso nakho kungafinyelelwa.
20kg/isikhwama 500kg/pallet
Ukupakisha okuqinisiwe
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Express
Ngaphansi kwe-100kg, izinsuku ezi-3-5
Isevisi yendlu ngendlu kulula ukuthatha izimpahla
Ngasolwandle
Over 300kg, Cishe izinsuku ezingu-30
Kudingeka ichweba eliya esikhungweni somdayiseli wokuthola imvume
Ngomoya
100kg-1000kg, 5-7Izinsuku
Kudingeka umthengisi wemvume yochwepheshe wesikhumulo sezindiza oya esikhumulweni sezindiza
I-Pure Methyltetrahydrofolate Calcium (5-MTHF-Ca)iqinisekiswe ngesitifiketi se-ISO, isitifiketi se-HALAL, nesitifiketi se-KOSHER.
Umehluko phakathi kwesizukulwane sesine se-folic acid (5-MTHF) kanye ne-folic acid yomdabu usekwakheni kwamakhemikhali nokutholakala kwe-bioavailability emzimbeni.
Isakhiwo samakhemikhali:I-folic acid yomdabu iwuhlobo lokwenziwa lwe-folate oludinga ukuguqulwa kwezinyathelo eziningi emzimbeni ngaphambi kokuthi lusetshenziswe.Ngakolunye uhlangothi, i-folic acid yesizukulwane sesine, eyaziwa nangokuthi i-5-MTHF noma i-Methyltetrahydrofolate, iwuhlobo olusebenzayo, olutholakala nge-bioavailable lwe-folate olungadingi ukuguqulwa.
I-Bioavailability:I-folic acid yendabuko idinga ukuguqulelwa esimweni sayo esisebenzayo, i-5-MTHF, ngokusabela kwe-enzymatic emzimbeni.Le nqubo yokuguqula iyahlukahluka phakathi kwabantu futhi ingathonywa ukuhlukahluka kofuzo noma ezinye izici.Ngokuphambene, i-5-MTHF isivele isesimweni sayo esisebenzayo, okwenza itholakale kalula ukuze ithathwe futhi isetshenziswe amaselula.
Ukumuncwa kanye nokusetshenziswa:Ukumuncwa kwe-folic acid yendabuko kwenzeka emathunjini amancane, lapho idinga ukuguqulwa ibe yifomu elisebenzayo nge-enzyme i-dihydrofolate reductase (DHFR).Kodwa-ke, le nqubo yokuguqula ayisebenzi kahle kwabanye abantu, okuholela ekwehleni kwe-bioavailability.I-5-MTHF, okuyifomu elisebenzayo, imuncwa kalula futhi isetshenziswe ngumzimba, yeqa inqubo yokuguqula.Lokhu kuyenza ibe yifomu ekhethwayo kubantu abanezinguquko zofuzo noma izimo ezithinta i-folate metabolism.
Ukufaneleka kwabantu abathile:Ngenxa yomehluko ekumunceni nasekusetshenzisweni, i-5-MTHF ithathwa njengefaneleka kakhulu kubantu abanezinguquko ezithile zofuzo, njengokuguquguquka kofuzo kwe-MTHFR, okungakhinyabeza ukuguqulwa kwe-folic acid ibe sesimweni sayo esisebenzayo.Kulaba bantu, ukusebenzisa i-5-MTHF ngokuqondile kungaqinisekisa amazinga afanele e-folate emzimbeni futhi kusekele imisebenzi ehlukahlukene yezinto eziphilayo.
Ukwengeza:I-folic acid yendabuko ivame ukutholakala ezithasiselweni, ekudleni okuqinile, nasekudleni okugayiwe, njengoba izinzile futhi ingabizi kakhulu ukuyikhiqiza.Kodwa-ke, kukhona ukutholakala okukhulayo kwezithako ze-5-MTHF ezihlinzeka ngefomu elisebenzayo ngokuqondile, okungaba yinzuzo kubantu abanobunzima bokuguqula i-folic acid.
Imiphumela emibi ye-folic acid yesizukulwane sesine (5-MTHF) ngokuvamile ayivamile futhi imnene, kodwa kubalulekile ukuqaphela ukusabela okungaba khona:
Ukungezwani komzimba:Njenganoma yisiphi isengezo noma imithi, ukungezwani komzimba kungenzeka.Izimpawu zingase zihlanganisa ukuqubuka, ukulunywa, ukuvuvukala, isiyezi, noma ukuphefumula kanzima.Uma uhlangabezana nanoma iyiphi yalezi zimpawu, funa usizo lwezokwelapha ngokushesha.
Izinkinga zokugaya ukudla:Abanye abantu bangase baphatheke kabi emathunjini, njengesicanucanu, ukuqunjelwa, igesi, noma isifo sohudo.Lezi zimpawu zivame ukuba zesikhashana futhi ziyancipha njengoba umzimba ulungisa ibhekwa.
Ukusebenzelana nemithi:I-5-MTHF ingase ihlanganyele nemithi ethile, okuhlanganisa imithi esetshenziselwa ukwelashwa komdlavuza, ama-anticonvulsants, i-methotrexate, nama-antibiotic athile.Kubalulekile ukukhuluma nomhlinzeki wakho wokunakekelwa kwezempilo uma uthatha noma yimiphi imithi ukuze uqinisekise ukuthi akukho ukuxhumana okungase kube khona.
I-overdose noma amazinga e-folate eyeqile:Nakuba kungavamile, ukudla ngokweqile kwe-folate (kuhlanganise ne-5-MTHF) kungaholela emazingeni aphezulu egazi we-folate.Lokhu kungase kufihle izimpawu zokushoda kwevithamini B12 futhi kuthinte ukuxilongwa nokwelashwa kwezimo ezithile.Kubalulekile ukulandela umthamo onconyiwe futhi uxhumane nochwepheshe bezempilo ukuze uthole isiqondiso.
Okunye okucatshangelwayo:Abesifazane abakhulelwe noma labo abahlela ukukhulelwa kufanele bakhulume nomhlinzeki wabo wezempilo ngaphambi kokuthatha imithamo ephakeme ye-5-MTHF, njengoba ukudla ngokweqile kwe-folate kungafihla izimpawu zokushoda kwe-vitamin B12, okubalulekile ekuthuthukisweni kwe-neural tube ku-fetus.
Njenganoma yisiphi isithasiselo sokudla noma imithi, kuyadingeka ukuxoxa ngokusetshenziswa kwe-folic acid yesizukulwane sesine (5-MTHF) nomhlinzeki wezempilo, ikakhulukazi uma unezimo zempilo ezicashile noma uthatha eminye imithi.Bangakunikeza iseluleko somuntu ngamunye ngokusekelwe ezidingweni zakho ezithile futhi basize ukuqapha noma yimiphi imiphumela emibi engaba khona.
I-folic acid yesizukulwane sesine, eyaziwa nangokuthi i-5-methyltetrahydrofolate (5-MTHF), iwuhlobo lwe-folate olusebenza ngokwebhayoloji olumuncwa kalula futhi lusetshenziswe umzimba uma kuqhathaniswa nokwengeza kwe-folic acid okungokwesiko.Nazi ezinye izifundo zesayensi ezisekela ukusebenza kahle kwayo:
Ukwenyuka kwe-bioavailability:I-5-MTHF ikhonjiswe ukuthi ine-bioavailability enkulu kune-folic acid.Ucwaningo olushicilelwe ku-American Journal of Clinical Nutrition luqhathanise i-bioavailability ye-folic acid kanye ne-5-MTHF kwabesifazane abanempilo.Ithole ukuthi i-5-MTHF yamuncwa ngokushesha futhi yaholela emazingeni aphezulu e-folate kumaseli abomvu egazi.
Isimo se-folate esithuthukisiwe:Ucwaningo oluningana lukhombisile ukuthi ukwengezwa nge-5-MTHF kungakhuphula ngempumelelo amazinga e-folate yegazi.Ocwaningweni olulawulwa ngokungahleliwe olushicilelwe ku-Journal of Nutrition, abacwaningi baqhathanisa imiphumela ye-5-MTHF kanye ne-folic acid supplementation esimweni se-folate kwabesifazane abanempilo.Bathole ukuthi i-5-MTHF yayisebenza kangcono ekwandiseni amazinga e-folate yamangqamuzana egazi abomvu kune-folic acid.
Ukuthuthukiswa kwe-folic acid metabolism:I-5-MTHF ikhonjiswe ukuthi idlula izinyathelo ze-enzymatic ezidingekayo ukuze kusebenze i-folic acid futhi ibambe iqhaza ngokuqondile kumetabolism ye-folic acid yeselula.Ucwaningo olwanyatheliswa ku-Journal of Nutrition and Metabolism lubonise ukuthi ukwesekwa kwe-5-MTHF kuthuthukisa i-intracellular folate metabolism kubantu abanezinguquko zofuzo kuma-enzyme abandakanyeka ekusebenzeni kwe-folic acid.
Amazinga e-homocysteine ancishisiwe:Amazinga aphezulu e-homocysteine, i-amino acid egazini, ahlotshaniswa nengozi eyengeziwe yezifo zenhliziyo.Ucwaningo luye lwabonisa ukuthi ukwesekwa kwe-5-MTHF kunganciphisa ngempumelelo amazinga e-homocysteine.Ukuhlaziywa kwe-meta okushicilelwe ku-Journal of the American College of Nutrition kuhlaziye izivivinyo ezilawulwa ngokungahleliwe ezingama-29 futhi kwaphetha ngokuthi ukwesekwa kwe-5-MTHF kwasebenza kakhulu kune-folic acid ekwehliseni amazinga e-homocysteine.
Kubalulekile ukuqaphela ukuthi izimpendulo zomuntu ngamunye ekwengezeni zingahlukahluka, futhi ukusebenza kahle kwe-5-MTHF kungase kuncike ezintweni ezifana nokuhluka kofuzo kuma-enzyme e-folate metabolism kanye nokudla okuphelele kokudla.Kuhlale kunconywa ukuthi uthintane nomhlinzeki wezokunakekelwa kwempilo ukuze uthole iseluleko esiqondene nawe mayelana nokwengeza kanye nokuxoxa nganoma yiziphi izinkathazo noma izimo ezithile zempilo.
