I-Methyltetrahydrofolate Calcium emsulwa (5MTHF-Ca)
I-Methyltetrahydrofolate emsulwa I-Calcium (5-MTHF-Ca) uhlobo lwe-folate olutholakala kakhulu emzimbeni futhi lungasetshenziswa kalula ngumzimba. Luyi-calcium salt ye-methyltetrahydrofolate, okuwuhlobo olusebenzayo lwe-folate emzimbeni. I-Folate iyi-vitamin B ebalulekile edlala indima ebalulekile ezinqubweni ezahlukene zamaseli, okuhlanganisa ukwakheka kwe-DNA, ukukhiqizwa kwamaseli abomvu egazi, kanye nomsebenzi wesistimu yezinzwa.
I-MTHF-Ca ivame ukusetshenziswa njengesengezo sokudla ukusekela amazinga e-folate kubantu abangase babe nobunzima bokugaya noma ukumunca uhlobo lokwenziwa lwe-folic acid olutholakala ekudleni okuqinisiwe kanye nezithasiselo. Iwusizo kakhulu kubantu abanezinguquko ezithile zofuzo ezingaphazamisa i-folate metabolism.
Ukwengeza i-MTHF-Ca kungasiza ekusekeleni impilo kanye nenhlalakahle iyonke, ikakhulukazi ezindaweni ezifana nempilo yenhliziyo, ukuthuthukiswa kwe-neural tube ngesikhathi sokukhulelwa, ukusebenza kwengqondo, kanye nokulawulwa kwemizwa. Kubalulekile ukuqaphela ukuthi i-MTHF-Ca kufanele isetshenziswe ngaphansi kwesiqondiso sochwepheshe bezempilo, ikakhulukazi kubantu abanezimo ezithile zezokwelapha noma labo abaphuza imithi ethile.
| Igama lomkhiqizo： | I-L-5-Methyltetrahydrofolate calcium |
| Amagama afanayo： | i-calcium engu-6S-5-Methyltetrahydrofolate; i-calcium engu-L-5-Methyltetrahydrofolate; i-calcium engu-Levomefolate |
| Ifomula Yamamolekyuli: | C20H23CaN7O6 |
| Isisindo sama-molecule: | 497.52 |
| Inombolo ye-CAS: | 151533-22-1 |
| Okuqukethwe: | ≥ 95.00% nge-HPLC |
| Ukubukeka: | Impuphu yekristalu emhlophe kuya kwephuzi elikhanyayo |
| Izwe azalelwe kulo: | IShayina |
| Iphakheji: | 20kg/isigubhu |
| Isikhathi sokuphelelwa yisikhathi: | Izinyanga ezingama-24 |
| Isitoreji: | Gcina endaweni epholile neyomile. |
| Izinto | Imininingwane | Imiphumela |
| Ukubukeka | Impuphu emhlophe noma engemhlophe | Qinisekisa |
| Ukuhlonza | Okuhle | Qinisekisa |
| I-calcium | 7.0%-8.5% | 8.4% |
| I-D-5-Methylfolate | ≤1.0 | Akutholakalanga |
| Izinsalela ezivuthayo | ≤0.5% | 0.01% |
| Amanzi | ≤17.0% | 13.5% |
| Ukuhlolwa (i-HPLC) | 95.0%-102.0% | 99.5% |
| Umlotha | ≤0.1% | 0.05% |
| Insimbi Enamandla | ≤20 ppm | Qinisekisa |
| Inani Eliphelele Lepuleti | ≤1000cfu/g | Abafanelekile |
| Imvubelo kanye neMold | ≤100cfu/g | Abafanelekile |
| I-E.coil | Okubi | Okubi |
| I-Salmonella | Okubi | Okubi |
Ukutholakala okuphezulu kwe-bioavailability:I-MTHF-Ca iwuhlobo lwe-folate olutholakala kalula emzimbeni, okusho ukuthi lungamuncwa kalula futhi lusetshenziswe umzimba. Lokhu kubalulekile ngoba abanye abantu bangase babe nobunzima bokuguqula i-folic acid yokwenziwa ibe yifomu yayo esebenzayo.
Uhlobo olusebenzayo lwe-folate:I-MTHF-Ca iwuhlobo olusebenzayo lwe-folate, olwaziwa ngokuthi i-methyltetrahydrofolate. Lolu hlobo lusetshenziswa kalula ngumzimba futhi aludingi ezinye izinqubo zokuguqulwa.
Usawoti weCalcium:I-MTHF-Ca iyi-calcium salt, okusho ukuthi iboshelwe ku-calcium. Lokhu kunikeza inzuzo eyengeziwe yokwengeza i-calcium kanye nokusekelwa kwe-folate. I-calcium ibalulekile empilweni yamathambo, ukusebenza kwemisipha, ukudluliselwa kwemizwa, kanye neminye imisebenzi yomzimba.
Kufanelekela abantu abanezakhi zofuzo ezithile:I-MTHF-Ca iwusizo kakhulu kubantu abanezinguquko ezithile zofuzo ezingaphazamisa ukusebenza kwe-folate. Lokhu kuhlukahluka kofuzo kungathinta ikhono lomzimba lokuguqula i-folic acid ibe yifomu layo elisebenzayo, okwenza kube nesidingo sokwengeza i-folate esebenzayo.
Isekela izici ezahlukene zempilo:Ukwengezwa kwe-MTHF-Ca kungasekela impilo kanye nenhlalakahle iyonke. Kuwusizo kakhulu empilweni yenhliziyo nemithambo yegazi, ukuthuthukiswa kwamapayipi ezinzwa ngesikhathi sokukhulelwa, ukusebenza kwengqondo, kanye nokulawulwa kwemizwa.
I-Methyltetrahydrofolate Calcium emsulwa (MTHF-Ca) inikeza izinzuzo eziningana zezempilo:
Ukusekelwa kwe-Folate metabolism:I-MTHF-Ca iwuhlobo lwe-folate olutholakala kakhulu futhi olusebenzayo. Lusiza ekusekeleni i-metabolism ye-folate yomzimba, okubalulekile ekwakhiweni kwe-DNA, ekukhiqizweni kwamaseli abomvu egazi, kanye nokusebenza kwamaseli jikelele.
Impilo yenhliziyo nemithambo yegazi:Amazinga e-folate anele abalulekile empilweni yenhliziyo nemithambo yegazi. Ukwengezwa kwe-MTHF-Ca kungasiza ekunciphiseni amazinga e-homocysteine, i-amino acid, okuthi uma iphakanyisiwe, ihlotshaniswe nengozi eyengeziwe yesifo senhliziyo nemithambo yegazi.
Ukusekelwa kokukhulelwa:I-MTHF-Ca ibalulekile ngesikhathi sokukhulelwa, njengoba isiza ekuvimbeleni ukukhubazeka kwe-neural tube ezinsaneni ezisakhula. Kunconywa abesifazane abaseminyakeni yokuzala ukuqinisekisa ukuthi banamazinga anele e-folate, ikakhulukazi ezigabeni zokuqala zokukhulelwa.
Ukulawulwa kwesimo sengqondo:I-Folate idlala indima ebalulekile ekwakhiweni kwama-neurotransmitter. Amazinga anele e-folate asekela ukukhiqizwa kwe-serotonin, i-dopamine, ne-norepinephrine, okubalulekile ekulawuleni imizwa. Ukwengezwa kwe-MTHF-Ca kungaba usizo kubantu abanezinkinga zemizwa, njengokucindezeleka.
Umsebenzi wokuqonda:I-Folate ibalulekile ekusebenzeni kwengqondo kanye nempilo yobuchopho. Ukwengezwa kwe-MTHF-Ca kungasekela inkumbulo, ukugxilisa ingqondo, kanye nokusebenza kwengqondo okuphelele, ikakhulukazi kubantu abadala.
Ukusekelwa kokudla okunempilo:Ukwengezwa kwe-MTHF-Ca kungaba wusizo kubantu abanezakhi zofuzo ezithinta i-metabolism ye-folate. Laba bantu bangase babe nobunzima bokuguqula i-folic acid yokwenziwa ibe yifomu yayo esebenzayo. I-MTHF-Ca inikeza uhlobo olusebenzayo lwe-folate ngqo, igwema noma yiziphi izinkinga zokuguqulwa.
Izakhamzimba kanye nezithako zokudla:I-MTHF-Ca ivame ukusetshenziswa njengesithako esiyinhloko kwizithako zokudla okunempilo kanye ne-nutraceuticals. Ihlinzeka ngohlobo lwe-folate olutholakala kakhulu emzimbeni, olunikeza izinzuzo eziningi zezempilo, njengoba kushiwo ngaphambili.
Ukuqinisa ukudla neziphuzo:I-MTHF-Ca ingafakwa emikhiqizweni yokudla neziphuzo ukuze iqiniswe nge-folate. Lokhu kubaluleke kakhulu emikhiqizweni enakekela abantu abanesifo se-folate noma izidingo ezengeziwe ze-folate, njengabesifazane abakhulelwe noma abantu abanezimo ezithile zempilo.
Izakhiwo zemithi:I-MTHF-Ca ingasetshenziswa ekwakhiweni kwemithi njengesithako esisebenzayo. Ingasetshenziswa emithini eqondisa izimo ezithile ezihlobene nokuntuleka kwe-folate noma ukuphazamiseka kwe-metabolism ye-folate, njenge-anemia noma ezinye izifo zofuzo.
Ukunakekelwa komuntu siqu kanye nezimonyo:I-MTHF-Ca ngezinye izikhathi ifakwa emikhiqizweni yokunakekelwa komuntu siqu kanye nezimonyo ngenxa yezinzuzo zayo ezingaba khona empilweni yesikhumba. I-Folate ihilelekile ezinqubweni ezahlukahlukene zamaseli esikhumba futhi ingasiza empilweni nasekubukekeni kwaso iyonke.
Ukudla kwezilwane:I-MTHF-Ca ingafakwa futhi ekudleni kwezilwane ukuze yengeze izilwane nge-folate. Lokhu kubaluleke kakhulu embonini yezilwane nezinkukhu, lapho ukuqinisekisa ukudla okwanele ukuze kukhule kahle futhi kube nempilo kubalulekile.
Lezi zinsimu zokusetshenziswa ziqokomisa ukuguquguquka kwe-MTHF-Ca kanye nokusetshenziswa kwayo okungenzeka ezimbonini ezahlukahlukene ukubhekana nezinkinga zempilo ezihlobene ne-folate kanye nezidingo zokudla okunempilo. Kodwa-ke, kubalulekile ukulandela iziqondiso zomthamo ezifanele kanye nokubonisana nochwepheshe lapho ufaka i-MTHF-Ca kunoma yimuphi umkhiqizo noma ifomula.
Ukutholwa kwezinto zokusetshenziswa:Inqubo iqala ngokuthola izinto zokusetshenziswa ezisezingeni eliphezulu. Izinto zokusetshenziswa eziyinhloko ezidingekayo ekukhiqizweni kwe-MTHF-Ca yi-folic acid kanye nosawoti we-calcium.
Ukuguqulwa kwe-folic acid ibe yi-5,10-Methylenetetrahydrofolate (5,10-MTHF):I-Folic acid iguqulwa ibe yi-5,10-MTHF ngenqubo yokunciphisa. Lesi sinyathelo ngokuvamile sihilela ukusetshenziswa kwezinto zokunciphisa ezifana ne-sodium borohydride noma ezinye izinto ezifanelekile zokuthuthukisa ukwakheka kwamangqamuzana.
Ukuguqulwa kwe-5,10-MTHF ibe yi-MTHF-Ca:I-5,10-MTHF iphinda isetshenziswe ngosawoti we-calcium ofanele, njenge-calcium hydroxide noma i-calcium carbonate, ukuze kwakheke i-Methyltetrahydrofolate Calcium (MTHF-Ca). Le nqubo ihilela ukuxuba ama-reactant nokuwavumela ukuthi asabele ngaphansi kwezimo ezilawulwayo, okuhlanganisa izinga lokushisa, i-pH, kanye nesikhathi sokusabela.
Ukuhlanzwa kanye nokuhlunga:Ngemva kokusabela, isixazululo se-MTHF-Ca sidlula ezinqubweni zokuhlanza ezifana nokuhlunga, ukuhlukanisa, noma ezinye izindlela zokuhlukanisa ukuze kususwe ukungcola kanye nemikhiqizo engase yakheke ngesikhathi sokusabela.
Ukomisa nokuqinisa:Isixazululo se-MTHF-Ca esihlanziwe sibe sesicutshungulwa kabanzi ukuze kususwe umswakama owedlulele futhi kuqiniswe umkhiqizo wokugcina. Lokhu kungafezwa ngamasu anjengokomisa ngokufutha noma ukomisa ngokuqandisa, kuye ngohlobo lomkhiqizo olufunwayo.
Ukulawulwa kwekhwalithi nokuhlolwa:Umkhiqizo wokugcina we-MTHF-Ca uthathwa izinyathelo zokulawula ikhwalithi eziqinile ukuqinisekisa ubumsulwa bawo, ukuzinza, kanye nokunamathela ezindinganisweni zekhwalithi ezibekiwe. Lokhu kungafaka phakathi ukuhlolwa kokungcola, amandla, kanye neminye imingcele efanele.
Ukupakisha nokugcina:I-MTHF-Ca ipakishwe ezitsheni ezifanele, iqinisekisa ukuthi ilebula lifanelekile futhi igcinwa kahle ukuze igcine ubuqotho bayo nokuqina kwayo. Ivame ukugcinwa endaweni eyomile, epholile kude nokukhanya kwelanga okuqondile.
Indawo Yokugcina: Gcina endaweni epholile, eyomile, nehlanzekile, Vikela emswakama nasekukhanyeni okuqondile.
Iphakheji Elikhulu: 25kg/isigubhu.
Isikhathi Sokuhola: Izinsuku eziyi-7 ngemuva kwe-oda lakho.
Impilo Yeshelufu: Iminyaka emi-2.
Phawula: Ukucaciswa okwenziwe ngezifiso nakho kungafinyelelwa.
20kg/isikhwama 500kg/iphalethi
Ukupakisha okuqinisiwe
Ukuphepha kwempahla
I-Express
Ngaphansi kwe-100kg, izinsuku ezi-3-5
Isevisi yokungena emnyango kulula ukuyithatha izimpahla
Ngasolwandle
Ngaphezulu kwama-300kg, cishe izinsuku ezingama-30
Kudingeka umthengisi wezinsizakalo zokukhishwa kwemvume ochwepheshe
Ngomoya
100kg-1000kg, Izinsuku ezi-5-7
Kudingeka umthengisi wezinsizakalo zokuhlanza ochwepheshe kusukela esikhumulweni sezindiza kuya esikhumulweni sezindiza
I-Methyltetrahydrofolate Calcium emsulwa (5-MTHF-Ca)iqinisekiswe ngesitifiketi se-ISO, isitifiketi se-HALAL, kanye nesitifiketi se-KOSHER.
Umehluko phakathi kwesizukulwane sesine se-folic acid (5-MTHF) kanye ne-folic acid yendabuko usekwakhekeni kwamakhemikhali kanye nokutholakala kwayo emzimbeni.
Isakhiwo samakhemikhali:I-folic acid yendabuko iwuhlobo lwe-folate oludinga ukudlula ezinyathelweni eziningi zokuguqulwa emzimbeni ngaphambi kokuba lusetshenziswe. Ngakolunye uhlangothi, i-folic acid yesizukulwane sesine, eyaziwa nangokuthi i-5-MTHF noma i-Methyltetrahydrofolate, iwuhlobo olusebenzayo nolutholakala kalula lwe-folate olungadingi ukuguqulwa.
Ukutholakala kwezinto eziphilayo:I-folic acid yendabuko idinga ukuguqulwa ibe yifomu layo elisebenzayo, i-5-MTHF, ngokusebenzisa ukusabela kwama-enzyme emzimbeni. Le nqubo yokuguqulwa iyahlukahluka phakathi kwabantu futhi ingathonywa ukushintshashintsha kwezakhi zofuzo noma ezinye izici. Ngokuphambene nalokho, i-5-MTHF isivele isesimweni sayo esisebenzayo, okwenza itholakale kalula ukuze ithathwe futhi isetshenziswe amaseli.
Ukumuncwa kanye nokusetshenziswa:Ukumuncwa kwe-folic acid yendabuko kwenzeka emathunjini amancane, lapho kudingeka khona ukuthi iguqulwe ibe yifomu esebenzayo yi-enzyme dihydrofolate reductase (DHFR). Kodwa-ke, le nqubo yokuguqulwa ayisebenzi kahle kwabanye abantu, okuholela ekutholakaleni okuphansi kwe-bioavailability. I-5-MTHF, njengoba iyifomu esebenzayo, imuncwa kalula futhi isetshenziswe umzimba, idlula inqubo yokuguqulwa. Lokhu kwenza kube yifomu ekhethwayo kubantu abanezinguquko zofuzo noma izimo ezithinta i-folate metabolism.
Ukufaneleka kwabantu abathile:Ngenxa yokwehluka kokumuncwa nokusetshenziswa, i-5-MTHF ibhekwa njengefaneleka kakhulu kubantu abanezinguquko ezithile zofuzo, njengokuguqulwa kwezakhi zofuzo ze-MTHFR, okungaphazamisa ukuguqulwa kwe-folic acid ibe yifomu yayo esebenzayo. Kulaba bantu, ukusebenzisa i-5-MTHF ngqo kungaqinisekisa amazinga afanele e-folate emzimbeni futhi kusekele imisebenzi eyahlukahlukene yezinto eziphilayo.
Ukwengezwa:I-folic acid yendabuko ivame ukutholakala ezithasiseleni, ekudleni okuqinisiwe, kanye nasekudleni okucutshungulwe, njengoba izinzile futhi ingabizi kakhulu ukuyikhiqiza. Kodwa-ke, kukhona ukutholakala okukhulayo kwezithasisele ze-5-MTHF ezinikeza ifomu elisebenzayo ngqo, okungaba wusizo kubantu abanobunzima bokuguqula i-folic acid.
Imiphumela emibi ye-folic acid yesizukulwane sesine (5-MTHF) ngokuvamile ayivamile futhi imnene, kodwa kubalulekile ukuqaphela ukusabela okungaba khona:
Ukusabela kokungezwani komzimba:Njenganoma yisiphi isithasiselo noma imithi, ukusabela kokungezwani komzimba kungenzeka. Izimpawu zingase zihlanganise ukuqubuka, ukulunywa, ukuvuvukala, isiyezi, noma ubunzima bokuphefumula. Uma uhlangabezana nanoma yiziphi zalezi zimpawu, funa usizo lwezokwelapha ngokushesha.
Izinkinga zokugaya ukudla:Abanye abantu bangase babe nokungakhululeki kwamathumbu, njengokucanuzela kwenhliziyo, ukuqunjelwa, igesi, noma uhudo. Lezi zimpawu ngokuvamile ziba zesikhashana futhi ziyancipha njengoba umzimba ujwayela isithasiselo.
Ukusebenzisana nemithi:I-5-MTHF ingase ihlangane nemithi ethile, okuhlanganisa imithi esetshenziselwa ukwelapha umdlavuza, imithi yokulwa nokuxhuzula, i-methotrexate, kanye nama-antibiotic athile. Kubalulekile ukukhuluma nomhlinzeki wakho wezempilo uma uthatha noma yimiphi imithi ukuqinisekisa ukuthi akukho ukuhlangana okungenzeka.
Amazinga e-folate ngokweqile noma ngokweqile:Nakuba kungavamile, ukudla i-folate ngokweqile (kufaka phakathi i-5-MTHF) kungaholela emazingeni aphezulu e-folate egazini. Lokhu kungase kufihle izimpawu zokuntuleka kwe-vitamin B12 futhi kuthinte ukuxilongwa nokwelashwa kwezimo ezithile. Kubalulekile ukulandela umthamo onconywayo bese uthintana nochwepheshe wezempilo ukuze uthole isiqondiso.
Ezinye izinto okufanele uzicabangele:Abesifazane abakhulelwe noma labo abahlela ukukhulelwa kufanele bakhulume nomhlinzeki wabo wezempilo ngaphambi kokuthatha imithamo ephezulu ye-5-MTHF, njengoba ukudla i-folate ngokweqile kungafihla izimpawu zokuntuleka kwe-vitamin B12, okubalulekile ekukhuleni kwe-neural tube embungwini.
Njenganoma yisiphi isithasiselo sokudla noma imithi, kubalulekile ukuxoxa ngokusetshenziswa kwe-folic acid yesizukulwane sesine (5-MTHF) nomhlinzeki wezempilo, ikakhulukazi uma unezinkinga zempilo eziyisisekelo noma uthatha eminye imithi. Bangakunikeza iseluleko esiqondene nawe ngokusekelwe ezidingweni zakho ezithile futhi basize ekuqapheni noma yimiphi imiphumela emibi engaba khona.
I-folic acid yesizukulwane sesine, eyaziwa nangokuthi i-5-methyltetrahydrofolate (5-MTHF), iwuhlobo lwe-folate olusebenzayo ngokwezinto eziphilayo olumuncwa kalula futhi lusetshenziswe umzimba uma kuqhathaniswa nokwengezwa kwe-folic acid yendabuko. Nazi ezinye izifundo zesayensi ezisekela ukusebenza kwayo:
Ukutholakala kwe-bioavailability okwandisiwe:I-5-MTHF iboniswe ukuthi inokutholakala kalula kwe-folic acid kakhulu kune-folic acid. Ucwaningo olushicilelwe kuyi-American Journal of Clinical Nutrition luqhathanise ukutholakala kalula kwe-folic acid kanye ne-5-MTHF kwabesifazane abanempilo. Luthole ukuthi i-5-MTHF yayimuncwa ngokushesha futhi yaholela emazingeni aphezulu e-folate emangqamuzaneni abomvu egazi.
Isimo se-folate esithuthukisiwe:Izifundo eziningana zibonise ukuthi ukwengezwa nge-5-MTHF kungakhuphula amazinga e-folate egazini ngempumelelo. Esivivinyweni esilawulwa ngokungahleliwe esanyatheliswa kuyi-Journal of Nutrition, abacwaningi baqhathanisa imiphumela ye-5-MTHF kanye ne-folic acid supplementation esimweni se-folate kwabesifazane abanempilo. Bathole ukuthi i-5-MTHF yayisebenza kangcono ekwandiseni amazinga e-folate yamangqamuzana abomvu egazi kune-folic acid.
Ukuthuthukiswa kwe-metabolism ye-folic acid:I-5-MTHF iboniswe ukuthi idlula izinyathelo ze-enzyme ezidingekayo ukuze kusebenze i-folic acid futhi ihlanganyele ngqo ekusetshenzisweni kwe-folic acid yeselula. Ucwaningo olushicilelwe kuyi-Journal of Nutrition and Metabolism lubonise ukuthi ukwengezwa kwe-5-MTHF kuthuthukisa ukusebenza kwe-folate ngaphakathi kweseli kubantu abanezinguquko zofuzo kuma-enzyme ahilelekile ekusebenzeni kwe-folic acid.
Amazinga e-homocysteine ancishisiwe:Amazinga aphezulu e-homocysteine, i-amino acid egazini, ahlotshaniswa nengozi eyengeziwe yezifo zenhliziyo nemithambo yegazi. Izifundo zibonise ukuthi ukwengezwa kwe-5-MTHF kunganciphisa ngempumelelo amazinga e-homocysteine. Ukuhlaziywa kwe-meta okwanyatheliswa kuyi-Journal of the American College of Nutrition kuhlaziye izivivinyo ezingama-29 ezilawulwa ngokungahleliwe futhi kwaphetha ngokuthi ukwengezwa kwe-5-MTHF kusebenze kangcono kune-folic acid ekunciphiseni amazinga e-homocysteine.
Kubalulekile ukuqaphela ukuthi izimpendulo zomuntu ngamunye ekufakweni kwe-supplement zingahluka, futhi ukusebenza kahle kwe-5-MTHF kungancika ezintweni ezifana nokwehluka kwezakhi zofuzo kuma-enzyme e-folate metabolism kanye nokudla okuvamile. Kunconywa njalo ukubonisana nomhlinzeki wezempilo ukuze uthole iseluleko esiqondene nawe mayelana nokufakwa kwe-supplement kanye nokuxoxa nganoma yiziphi izinkinga noma izimo ezithile zempilo.
