I-Sinomenine Hydrochloride Powder
I-Sinomenine Hydrochloride iyinhlanganisela yamakhemikhali etholakala esitshalweni i-Sinomenium acutum, evame ukutholakala eMpumalanga Asia. Kuyi-alkaloid ebilokhu isetshenziswa ngokwesiko emithini yamaShayina ngezindawo zayo zokulwa nokuvuvukala kanye ne-analgesic. Ifomu le-hydrochloride lingusawoti othuthukisa ukunyibilika nokuzinza kwe-compound, okulenze lifaneleke kakhulu ukusetshenziswa kwemithi.
I-Sinomenine Hydrochloride iye yafundelwa imiphumela yayo yokwelapha engaba khona ekwelapheni izimo ezinjenge-rheumatoid arthritis, ngenxa yekhono layo lokushintsha amasosha omzimba nokunciphisa ukuvuvukala. Isebenza ngokuvimbela ukukhiqizwa kwama-cytokines ane-pro-inflammatory kanye nabanye abalamuleli abahilelekile ekuphenduleni kokuvuvukala.
Ngokungeziwe emiphumeleni yayo yokulwa nokuvuvukala ne-analgesic, i-Sinomenine Hydrochloride iphinde yabonisa amandla e-neuroprotection, anti-fibrosis, kanye nemisebenzi yokulwa nesimila ezifundweni ezihlukahlukene zangaphambi komtholampilo.
Igama Elisemthethweni:(9a,13a,14a)-7,8-didehydro-4-hydroxy-3,7-dimethoxy-17-methyl-morphinan-6-one, monohydrochloride
Inombolo ye-CAS: 6080-33-7
Synonimes:Cucoline NSC 76021
I-Molecular Formula: C19H23NO4 • HCl
Isisindo sefomula: 365.9
Ubumsulwa:≥98% I-crystalline solid
I-Solubility(Funda Ngokuhlukahluka Kokuncibilika)
I-DMF: 30 mg/ml
I-DMSO: 30 mg/ml
I-Ethanol: 5 mg/ml
I-PBS (pH 7.2): 5 mg/ml
Umsuka:Isitshalo/Sinomenium acutum
Ulwazi Lokuthumela Nokugcinwa:
Isitoreji -20°C
Ukuthumela: Ithempelesha Yegumbi
Ukuzinza:≥ iminyaka emi-4
| Into | Ukucaciswa | Umphumela |
| I-Assay(HPLC) | 98.0% | 98.12% |
| Ukubukeka | Impushana emhlophe | Iyahambisana |
| Usayizi Wezinhlayiyana | 98% kuya ku-80mesh | Iyahambisana |
| Iphunga | Isici | Iyahambisana |
| Nambitha | Isici | Iyahambisana |
| Izici Zomzimba | ||
| Ukulahlekelwa Ekumisweni | ≤0.5% | 0.38% |
| Umlotha | ≤0.5% | 0.46% |
| Izinsimbi ezinzima | ||
| Izinsimbi ezinzima (njenge-Pb) | Amazinga e-USP(<10ppm) | <10ppm |
| I-Arsenic(As) | ≤2ppm | 0.78ppm |
| Ukuhola (Pb) | ≤2ppm | 1.13ppm |
| I-Cadmium(Cd) | ≤lppm | 0.36ppm |
| I-Mercary(Hg) | ≤0.1ppm | 0.01ppm |
| Izinsalela zezibulala-zinambuzane | Ayitholakali | Ayitholakali |
| Isamba se-PlateCount | I-NMT 10000cfu/g | 680 cfu/g |
| Isamba seYeast &Mold | I-NMT 100cfu/g | 87 cfu/g |
| E.Coli | I-NMT 30cfu/g | 10 cfu/g |
| I-Salmonella | Okubi | Okubi |
| Isiphetho | Ihambisana Nezinga Lebhizinisi | |
Imiphumela eyinhloko ye-Sinomenine Hydrochloride ihlanganisa:
(1) I-Anti-inflammatory: Yehlisa ukuvuvukala.
(2) I-analgesic: Inikeza ukukhululeka kobuhlungu.
(3) I-Immunosuppressive: Icindezela umsebenzi wamasosha omzimba.
(4) I-Anti-rheumatic: Yelapha isifo samathambo.
(5) I-Neuroprotective: Ivikela amangqamuzana ezinzwa emonakalweni.
(6) I-Anti-fibrotic: Ivimbela noma inciphisa i-tissue fibrosis.
I-Sinomenine Hydrochloride isetshenziswa ngokuyinhloko kulezi zindawo ezilandelayo:
(1) I-Rheumatology: Ukwelashwa kwe-rheumatoid arthritis.
(2) Ukuphathwa Kwezinhlungu: Ukunciphisa ubuhlungu obungapheli.
(3) Ukulwa nokuvuvukala: Ukunciphisa ukuvuvukala.
(4) I-Immunomodulation: Ukuguqulwa kwamasosha omzimba.
(5) I-Neuroprotection: Ukusetshenziswa okungenzeka ku-neuroprotective therapy.
Inqubo yokukhiqiza ye-Sinomenine Hydrochloride Powder ingafingqwa ngale ndlela elandelayo:
Ukulungiselela Amakhambi:Ukuhlanza nokomisa impahla yezitshalo eluhlaza.
Isizinda:Ukusebenzisa izincibilikisi ezifana ne-ethanol ukukhipha i-sinomenine esitshalweni.
Ukugxila:Ukuhwamuka kwe-solvent ukuze kugxiliswe okuqukethwe kwe-sinomenine.
I-Alkalization:Ukulungisa i-pH ukuguqula i-sinomenine ibe ifomu layo likasawoti.
Ukukhishwa Kwe-Liquid-Liquid:Ukuhlanza ngezincibilikisi eziphilayo njenge-anisole noma i-1-heptanol.
Ukugeza:Ukugeza ngamanzi ukuze kukhishwe ukungcola kanye neminonjana ye-solvent.
I-Acidification:Ukunciphisa i-pH ukuze kuncishiswe i-sinomenine hydrochloride.
I-Crystallization:Ukwakha amakristalu e-sinomenine hydrochloride.
Ukwehlukana:I-centrifuging noma ukuhlunga ukuhlukanisa amakristalu esixazululweni.
Ukomisa:Ukukhipha umswakama osele kumakristalu.
Ukugaya:Ukugaya amakristalu omisiwe abe yimpushana enhle.
Ukuhlunga:Ukuqinisekisa ukusatshalaliswa kosayizi wezinhlayiyana ezifanayo.
Ikhwalithi yokulawula:Ukuhlola ubumsulwa, ukugxilisa ingqondo, kanye namazinga e-microbiological.
Ukupakishwa:Ukupakishwa okungahlanzekile nokuvikelekile ukuze kusatshalaliswe.
Isitoreji: Gcina endaweni epholile, eyomile, nehlanzekile, Vikela kumswakama nokukhanya okuqondile.
Iphakethe lenqwaba: 25kg / isigubhu.
Isikhathi Sokuhola: Izinsuku eziyi-7 ngemuva kwe-oda lakho.
Impilo yeshelufu: iminyaka emi-2.
Phawula: Ukucaciswa okwenziwe ngokwezifiso nakho kungafinyelelwa.
Express
Ngaphansi kwe-100kg, izinsuku ezi-3-5
Isevisi yendlu ngendlu kulula ukuthatha izimpahla
Ngasolwandle
Over 300kg, Cishe izinsuku ezingu-30
Kudingeka ichweba eliya esikhungweni somdayiseli wokuthola imvume
Ngomoya
100kg-1000kg, 5-7Izinsuku
Kudingeka umthengisi wemvume yochwepheshe wesikhumulo sezindiza oya esikhumulweni sezindiza
I-Bioway Organic ithole i-USDA ne-EU organic, BRC, ISO, HALAL, KOSHER, nezitifiketi ze-HACCP.
