I-Lycorine Hydrochloride

Omqondofana:I-Lycorine chloride; I-Lycorine HCl; I-Lycorine (i-hydrochloride)
I-MOQ:10G
INOMBOLO YECAS.2188-68-3
Ubumsulwa:I-NLT 98%
Ukubukeka:Impushana emhlophe
I-Melting Point:206ºC
Indawo yokubilisa:385.4±42.0ºC
Ukuminyana:1.03±0.1g/cm3
Ukunyibilika:Kancane ku-95% wotshwala, hhayi kahle emanzini, hhayi ku-chloroform
Isitoreji:Izinzile esimweni esomile, gcina ku-+4 °C, endaweni emnyama.


Imininingwane Yomkhiqizo

Omaka bomkhiqizo

Isingeniso Somkhiqizo

I-Lycorine hydrochloride iphuma kokumhlophe kuya kokumhlophe okuyimpushana ye-alkaloid lycorine, etholakala ezitshalweni ze-Lycoris radiata (L'Her.), futhi ingeyomndeni wakwa-Amaryllidaceae. I-Lycorine hydrochloride inemiphumela ehlukahlukene engaba khona yezemithi, okuhlanganisa i-anti-tumor, anti-cancer, anti-HCV, anti-inflammatory, anti-bacterial, anti-virus, anti-angiogenesis, kanye nezakhiwo zokulwa nomalaleveva. Iyancibilika emanzini, i-DMSO, ne-ethanol. Isakhiwo sayo samakhemikhali sibonakala ngohlaka oluyinkimbinkimbi lwe-steroidal olunokunambitheka okubabayo namaqembu amaningi asebenzayo, okuhlanganisa namaqembu e-hydroxyl nama-amino, anikela emisebenzini yawo yezinto eziphilayo.

Ukucaciswa

Igama lomkhiqizo I-Lycorine hydrochloride CAS: 2188-68-3
Umthombo Wezitshalo I-Lycoris
Isimo sesitoreji Gcina nge-seal ekamelweni lokushisa Idethi yombiko 2024.08.24

 

Into Okujwayelekile Umphumela
Ubumsulwa(I-HPLC I-Lycorine hydrochloride≥98% 99.7%
Ukubukeka Impushana emhlophe Kuyavumelana
Isici somzimbaics    
Usayizi wezinhlayiya I-NLT100% 80I-Mesh Kuyavumelana
Ukulahlekelwa ekomisweni ≤1.0% 1.8%
Kunzima insimbi    
Izinsimbi eziphelele ≤10.0ppm Kuyavumelana
Ukuhola ≤2.0ppm Kuyavumelana
I-Mercury ≤1.0ppm Kuyavumelana
I-Cadmium ≤0.5ppm Kuyavumelana
I-Microorganism    
Isamba senani lamagciwane ≤1000cfu/g Kuyavumelana
Imvubelo ≤100cfu/g Kuyavumelana
I-Escherichia coli Akufakiwe Ayitholakali
I-Salmonella Akufakiwe Ayitholakali
I-Staphylococcus Akufakiwe Ayitholakali
Iziphetho Ufanelekile

Izici

Izici:
(1) Ubumsulwa obukhulu:Umkhiqizo wethu ucutshungulwa ngokucophelela ukuze kuqinisekiswe izinga eliphezulu lokuhlanzeka, okubalulekile ekusebenzeni kwawo nokuphepha ezinhlelweni ezihlukahlukene.
(2) Izici Zokuvikela Umdlavuza:Ibonise imiphumela ebalulekile yokulwa nomdlavuza ngokumelene nezinhlobo ezihlukahlukene zomdlavuza, kokubili ku-vitro kanye ne-vivo, ngokusebenzisa izindlela ezifana nokufaka ukuboshwa komjikelezo wamaseli, ukucupha i-apoptosis, nokuvimbela i-angiogenesis.
(3) Isenzo Esihloselwe Kaningi:I-Lycorine hydrochloride kukholakala ukuthi isebenzisana nokuhlosiwe kwamangqamuzana amaningi, ihlinzeka ngokusebenza kahle kwe-spectrum ebanzi ngokumelene namaseli omdlavuza.
(4) Ubuthi obuphansi:Ibonisa ubuthi obuphansi kumaseli avamile, okuyisici esibalulekile ekusetshenzisweni kwayo okunamandla njenge-ejenti yokwelapha.
(5) Iphrofayili Yekhemisi:Umkhiqizo uye wafundelwa i-pharmacokinetics yawo, okhombisa ukumuncwa okusheshayo nokuqedwa ngokushesha ku-plasma, okubalulekile ekudoseni nasekuhleleni ukwelashwa.
(6) Imiphumela ye-Synergistic:I-Lycorine hydrochloride ibonise imiphumela ethuthukisiwe lapho isetshenziswa ihlanganiswe nezinye izidakamizwa, ezingaba yinzuzo ekunqobeni ukumelana nezidakamizwa kanye nokwenza ngcono imiphumela yokwelashwa.
(7) Kusekelwe ucwaningo:Umkhiqizo usekelwa ucwaningo olunzulu, olunikeza isisekelo esiqinile sokusetshenziswa kwawo ekuthuthukisweni kwemithi kanye nezicelo zomtholampilo.
(8) Ukuqinisekisa Ikhwalithi:Izinyathelo eziqinile zokulawula ikhwalithi zikhona kuyo yonke inqubo yokukhiqiza ukuze kuqinisekiswe ukuvumelana nokwethembeka komkhiqizo.
(9) Izinhlelo Ezihlukahlukene:Ifanele ukusetshenziswa ocwaningweni nasekuthuthukisweni kwezicelo zemithi, okuhlanganisa ukutholwa kwezidakamizwa nokuthuthukiswa kokwelashwa komdlavuza.
(10) Ukuthobela:Kwenziwe ngokulandela amazinga e-GMP ukuze kuqinisekiswe ukuphepha nokusebenza komkhiqizo.

Isicelo

(1) Imboni yezemithi:I-Lycorine hydrochloride isetshenziselwa ukuthuthukiswa kwemithi elwa namagciwane kanye ne-anticancer.
(2) Imboni ye-Biotechnology:Isetshenziswa ocwaningweni nasekuthuthukisweni kwama-ejenti amasha okwelapha kanye nokwakhiwa kwezidakamizwa.
(3) Ucwaningo lomkhiqizo wemvelo:I-Lycorine hydrochloride ifundelwa izinzuzo zayo zezempilo ezingaba khona kanye nezakhiwo zokwelapha.
(4) Imboni yamakhemikhali:Ingase isetshenziswe njengekhemikhali emaphakathi ekuhlanganiseni ezinye izinhlanganisela.
(5) Imboni yezolimo:I-Lycorine hydrochloride iphenywe amandla ayo njengesibulala-zinambuzane semvelo kanye nesilawuli sokukhula kwezitshalo.

Imininingwane Yokukhiqiza

Inqubo yokukhipha i-lycorine hydrochloride ngokuvamile ihlanganisa izinyathelo ezibalulekile ezilandelayo zokuqinisekisa ukuhlanzeka kwe-solvent nokuthuthukisa izinga lokubuyisela:
(1) Ukukhetha impahla eluhlaza kanye nokwelashwa kusengaphambili:Khetha izinto ezisetshenziswayo zesitshalo se-Amaryllidaceae ezifanele, njengama-Amaryllis, bese uwageza, womise futhi uwachoboze ukuze uqinisekise ubumsulwa bezinto ezingavuthiwe futhi ubeke isisekelo sokusikhipha okulandelayo.
(2)Ukwelashwa kwe-enzyme ehlanganisiwe:Sebenzisa ama-enzyme ayinkimbinkimbi (afana ne-cellulase ne-pectinase) ukuze ulungise kuqala izinto ezingavuthiwe ezichotshoziwe ukuze ubolise izindonga zamaseli ezitshalo futhi uthuthukise ukusebenza kahle kokukhipha okulandelayo.
(3)Nciphisa i-hydrochloric acid leaching:Xuba izinto zokusetshenziswa ngaphambilini nesisombululo se-hydrochloric acid esixutshwe ukuze ukhiphe i-lycorine. Ukusetshenziswa kwe-hydrochloric acid kusiza ukwandisa ukunyibilika kwe-lycorine, ngaleyo ndlela kuthuthukise ukusebenza kahle kokukhipha.
(4)Isizinda esisizwa nge-Ultrasonic:Ukusetshenziswa kwe-ultrasonic-assisted extraction technology kungasheshisa inqubo yokuqedwa kwe-lycorine ku-solvent futhi kuthuthukise ukusebenza kahle nokuhlanzeka kokukhipha.
(5)Ukukhishwa kwe-Chloroform:Ukukhishwa kwenziwa ngezincibilikisi zemvelo ezifana ne-chloroform, futhi i-lycorine idluliswa isuka esigabeni samanzi iye esigabeni sezinto eziphilayo ukuze kuqhutshekwe kuhlanzwe inhlanganisela ehlosiwe.
(6)Ukubuyiselwa kwe-solvent:Ngemuva kwenqubo yokukhipha, i-solvent ibuyiselwa ngokuhwamuka noma i-distillation ukunciphisa ukusetshenziswa kwe-solvent nokuthuthukisa umnotho.
(7)Ukuhlanzwa nokomiswa:Ngezinyathelo ezifanele zokuhlanzwa nokomisa, i-lycorine hydrochloride powder ehlanzekile itholakala.
Kuyo yonke inqubo yokukhipha, ukulawula ukukhethwa kwe-solvent, izimo zokukhipha (njengenani le-pH, izinga lokushisa, nesikhathi), kanye nezinyathelo zokuhlanza ezilandelayo kuyisihluthulelo sokuqinisekisa ukuhlanzeka kwe-solvent kanye nokwenza ngcono izinga lokubuyisela. Ukusetshenziswa kwemishini yesimanje yokukhipha nokuhlanza, njengama-extractors e-ultrasonic kanye nezinhlelo ze-high-performance liquid chromatography (HPLC), futhi kusiza ukuthuthukisa ukusebenza kahle kokukhipha kanye nekhwalithi yomkhiqizo.

Ukupakisha kanye Nesevisi

Isitoreji: Gcina endaweni epholile, eyomile, nehlanzekile, Vikela kumswakama nokukhanya okuqondile.
Iphakethe lenqwaba: 25kg / isigubhu.
Isikhathi Sokuhola: Izinsuku eziyi-7 ngemuva kwe-oda lakho.
Impilo yeshelufu: iminyaka emi-2.
Phawula: Ukucaciswa okwenziwe ngokwezifiso nakho kungafinyelelwa.

ukupakisha

Izindlela Zokukhokha Nezokudiliva

Express
Ngaphansi kwe-100kg, izinsuku ezi-3-5
Isevisi yendlu ngendlu kulula ukuthatha izimpahla

Ngasolwandle
Over 300kg, Cishe izinsuku ezingu-30
Kudingeka ichweba eliya esikhungweni somdayiseli wokuthola imvume

Ngomoya
100kg-1000kg, 5-7Izinsuku
Kudingeka umthengisi wemvume yochwepheshe wesikhumulo sezindiza oya esikhumulweni sezindiza

trans

Isitifiketi

I-Bioway Organic ithole i-USDA ne-EU organic, BRC, ISO, HALAL, KOSHER, nezitifiketi ze-HACCP.

CE

I-FAQ (Imibuzo Evame Ukubuzwa)

Yiziphi izitshalo eziqukethe i-lycorine?

I-Lycorine iyi-alkaloid eyenzeka ngokwemvelo engatholakala ezitshalweni ezimbalwa, ikakhulukazi emndenini we-Amaryllidaceae. Nazi ezinye izitshalo ezaziwa ukuthi ziqukethe i-lycorine:
I-Lycoris radiata(eyaziwa nangokuthi i-red spider lily noma i-manjushage) isitshalo sendabuko saseShayina esiqukethe i-lycorine.
I-Leucojum aestivum(ikhekheba leqhwa lasehlobo), yaziwa nangokuthi iqukethe i-lycorine.
Ungernia sewertzowiingesinye isitshalo somndeni wakwa-Amaryllidaceae okubikwa ukuthi siqukethe i-lycorine.
I-Hippeastrum hybrid (umnduze wama-Easter)kanye nezinye izitshalo ezihlobene ne-Amaryllidaceae ziyimithombo eyaziwayo ye-lycorine.
Lezi zitshalo zisakazwa kabanzi ezindaweni ezishisayo nezishisayo emhlabeni jikelele futhi zinomlando omude wokusetshenziswa kwezokwelapha zendabuko. Ukuba khona kwe-lycorine kulezi zitshalo kube yindaba yocwaningo ngenxa yezakhiwo zayo zemithi ezingase zibe khona, okuhlanganisa nemiphumela yayo ebalulekile yokulwa nomdlavuza njengoba kuboniswe ezifundweni ezihlukahlukene.

Iyini imiphumela emibi ye-lycorine?

I-Lycorine iyi-alkaloid yemvelo enezinhlobonhlobo zemiphumela yemithi, okuhlanganisa ukusetshenziswa kwayo okungenzeka ekwelapheni umdlavuza. Nakuba ibonise imiphumela ethembisayo ezifundweni ezihlukahlukene, kunemiphumela emibi ebikiwe kanye nokucatshangelwa okuhambisana nokusetshenziswa kwayo:
Ubuthi obuphansi: I-Lycorine kanye nosawoti wayo we-hydrochloride ngokuvamile ibonisa ubuthi obuphansi, okuyisici esivumayo ekusetshenzisweni komtholampilo. Kuboniswe ukuthi kunemiphumela emibi emincane kumaseli omuntu avamile namagundane anempilo, okuphakamisa izinga elithile lokukhetha amangqamuzana omdlavuza phezu kwezicubu ezivamile.
Imiphumela ye-Emetic Yesikhashana: Ukucanuzela kwesikhashana nokuhlanza kuye kwaqashelwa kulandela umjovo ongaphansi kwesikhumba noma we-intravenous we-lycorine hydrochloride, ngokuvamile wehla kungakapheli amahora angu-2.5 ngaphandle kokuphazamisa ukuphepha kwe-biochemical noma i-hematological.
Akukho Ukuhlanganiswa Kwezimoto Ezikhubazekile: Ucwaningo luye lwabonisa ukuthi imithamo ye-serial ye-lycorine ayithinti ukuhlanganiswa kwezimoto kumagundane, njengoba ihlolwe ukuhlolwa kwe-rotarod, okubonisa ukuthi ayiholeli ku-central nervous system (CNS) imiphumela emibi ehlobene nokulawulwa kwezimoto.
Umthelela Kumsebenzi We-Locomotor Ozenzakalelayo: Ngomthamo we-30 mg / kg, i-lycorine ibonwe ukuthi iphazamise umsebenzi we-locomotor ngokuzenzekelayo kumagundane, njengoba kuboniswa ukwehla kokuziphatha kokukhulisa kanye nokwanda kokungahambi kahle.
Ukuziphatha Okujwayelekile Nenhlalakahle: Umthamo we-10 mg/kg we-lycorine awuzange uphazamise ukuziphatha okuvamile nokuphila kahle kwamagundane, okuphakamisa ukuthi lokhu kungaba umthamo ophelele wokuhlolwa kokuphumelela kokwelapha okuzayo.
Ayikho Imithelela Emibi Ephawulekayo Esisindweni Somzimba Noma Isimo Sezempilo: Ukuphathwa kwe-lycorine ne-lycorine hydrochloride akuzange kubangele imiphumela engemihle ebonakalayo esisindweni somzimba noma isimo sezempilo sisonke kumamodeli wamagundane aphethe isimila.
Kubalulekile ukuqaphela ukuthi nakuba i-lycorine ibonise amandla ophenyo lwangaphambi komtholampilo, ukuhlolwa kobuthi besikhathi eside kusantuleka. Ucwaningo olwengeziwe luyadingeka ukuze uqonde ngokugcwele iphrofayili yayo yokuphepha, ikakhulukazi ukusetshenziswa kwesikhathi eside nasezilungiselelweni zomtholampilo. Imiphumela emibi nokuphepha kwe-lycorine kungase kuhluke kuye ngokuthi umthamo, indlela yokuphatha, kanye nezici zesiguli ngasinye. Hlala uthintana nochwepheshe bezempilo ngaphambi kokucabangela ukusetshenziswa kwanoma yisiphi isithasiselo esisha noma ukwelashwa.


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