ILycorine Hydrocloworide
I-Lycorine Hydrochloride i-White to White-White Powder etholwa yi-Alkaliid Lycorine, etholakala ezitshalweni zeLycoris Radiata (L'RY.), Futhi ingeyomndeni wakwa-Amaryllidaceae. ILycorine Hydrochloride inemiphumela ehlukahlukene yemithi, kufaka phakathi i-anti-umdlavula, umdlavuza, i-anti-HCV, i-anti-bactus, i-anti-malaria. Kuyancibilika emanzini, DMSO, ne-ethanol. Isakhiwo saso samakhemikhali sibonakaliswa ngohlaka oluyinkimbinkimbi lwe-steroadal ngokunambitheka okubabayo ngamaqembu amaningi asebenzayo, kufaka phakathi amaqembu e-hydroxy kanye nama-amino, afaka isandla emisebenzini yawo yezinto eziphilayo.
| Igama lomkhiqizo | I-Lycorine Hydrocloride CAS: 2188-68-3 | ||
| Umthombo wesitshalo | ILycoris | ||
| Isimo sokugcina | Gcina ngophawu ekushiseni kwegumbi | Bika usuku | 2024.08.24 |
| Into yendaba | -Vamile | Umphumela |
| Ubumsulwa(I-HPLCIsihlehlukene | ILycorine Hydrocloworide≥98% | 99.7% |
| Ukubonakala | Off-white powder | Kuvumelana |
| Isici esibonakalayoikalikiso | ||
| Usayizi wezinhlayiyana | NLT100% 80Inzilo | Kuvumelana |
| Ukulahleka kokuwomile | ≤1.0% | I-1.8% |
| -Sindayo insimbi yanama ini | ||
| Izinsimbi eziphelele | ≤10.0ppm | Kuvumelana |
| Hola | ≤2.0PPM | Kuvumelana |
| Ucembekile | ≤1.0PPM | Kuvumelana |
| Inhlamvu kaCadmium | ≤0.5ppm | Kuvumelana |
| I-Microorganism | ||
| Inani eliphelele lamagciwane | ≤1000cFU / g | Kuvumelana |
| Imvubelo | ≤100cFU / g | Kuvumelana |
| Escherichia coli | Ayifakiwe | Ayitholakali |
| Salmonella | Ayifakiwe | Ayitholakali |
| Staphylococcus | Ayifakiwe | Ayitholakali |
| Iziphetho | -Nokwazi | |
Izici:
(1) Ukuhlanzeka okuphezulu:Umkhiqizo wethu ucutshungulwa ngokucophelela ukuze uqinisekise ukuthi izinga eliphakeme lobumsulwa, elibaluleke kakhulu ekusebenzeni kwalo nokuphepha kuzicelo ezahlukahlukene.
(2) Izakhiwo ze-Anticancer:Ikhombise imiphumela ebalulekile yezimomishi ezinhlangoni ezahlukahlukene zomdlavuza, eVivo, ngezindlela ezifana nokubopha ukuboshwa kweseli, okubangela i-apoptosis, nokuvimbela i-angiogenesis.
(3) Isenzo esiningi:ILycorine hydrochloride kukholelwa ukuthi iyaxhumana nemigomo eminingi yamamolekyuli, inikezela ngempumelelo ebanzi ngokumelene namaseli omdlavuza.
(4) Ubuthi obuphansi:Kukhonjiswa ubuthi obuphansi kumaseli ajwayelekile, okuyinto ebalulekile ekusetshenzisweni kwayo okungenzeka njenge-ejenti yokwelapha.
(5) Iphrofayili ye-Pharmacokinetic:Umkhiqizo ufundelwe ama-pharmacokinetics awo, ekhombisa ukumuncwa okusheshayo nokuqedwa okusheshayo kusuka ku-plasma, okubalulekile ekuhlelweni kwe-dosing nokwelashwa.
(6) Imiphumela ye-Synergistic:ILycorine Hydrochloride ikhombisile imiphumela ethuthukisiwe lapho isetshenziswa ngokuhlanganiswa nezinye izidakamizwa, ezingasiza ekunqobeni ukumelana nezidakamizwa kanye nokwenza ngcono imiphumela yokwelashwa.
(7) Ukucwaninga okusekelwa:Umkhiqizo usekelwa ucwaningo olunzulu, onikeza isisekelo esiqinile sokusetshenziswa kwalo ekuthuthukisweni kwemithi kanye nezicelo zemitholampilo.
(8) Isiqinisekiso sekhwalithi:Izindlela zokulawula ezisezingeni eliphakeme zisendaweni yonke inqubo yokukhiqiza ukuze kuqinisekiswe ukuvumelana nokwethenjwa komkhiqizo.
(9) Izicelo eziguquguqukayo:Ilungele ukusetshenziswa ocwaningweni nasekuthuthukisweni kwezicelo zemithi, kufaka phakathi ukutholakala kwezidakamizwa kanye nokuthuthukiswa kokwelashwa komdlavuza.
(10) Ukuhambisana:Kwenziwe amazinga we-GMP alandelayo ukuqinisekisa ukuphepha kanye nokusebenza kwempumelelo komkhiqizo.
(1) Imboni yezemithi:ILycorine Hydrocloworide isetshenziswa ekuthuthukisweni kwemithi ye-antiviral ne-anticancer.
(2) Imboni ye-biotechnology:Kusetshenziswa ocwaningweni nasekuthuthukisweni kwama-ejenti amasha okulapha kanye nokwakhiwa kwezidakamizwa.
(3) Ucwaningo Lomkhiqizo Wemvelo:ILycorine Hydrochloride ifundwa ngezinzuzo zayo zezempilo ezingaba khona kanye nezakhiwo zokwelapha.
(4) Imboni yamakhemikhali:Ingasetshenziswa njengomphakathi wamakhemikhali ekuhlanganiseni kwezinye izinhlanganisela.
(5) Imboni yezolimo:ILycorine Hydrocloworide iye yaphenywa ngamathuba ayo njenge-pesticide yemvelo noMlawuli Wokukhula Wokutshala.
Inqubo yokukhishwa kweLycorine Hydrochloride imvamisa ifaka lezi zinyathelo ezisemqoka ezilandelayo zokuqinisekisa ubumsulwa be-solvent futhi bathuthukise izinga lokutakula:
(1) Ukukhethwa okubonakalayo okuluhlaza nokuhlekisa:Khetha izinto ezifanele ze-Amaryllidaceae zezinto ezisetshenziswayo, ezifana nama-Amaryllis ama-Amaryllis, bese ugeza, womile futhi uzigeze ukuze uqinisekise ubumsulwa bezinto ezisetshenziswayo.
(2)Ukuhlelwa kwe-enzyme okuhlanganisiwe:Sebenzisa ama-enzyme ayinkimbinkimbi (njenge-mopulasise kanye ne-pectiniswase) ukuze wenze sengathi izinto zokwakha eziqhekekile zokubola izindonga zezitshalo futhi zithuthukise ukusebenza kahle kokukhishwa kwezitshalo futhi kuthuthukise ukusebenza kahle kokukhishwa kwezitshalo futhi kuthuthukise ukusebenza kahle kokukhishwa kwezitshalo futhi kuthuthukise ukusebenza kahle kokukhishwa.
(3)Dlulisa i-hydrochloric acid leaching:Hlanganisa izinto ezivuthayo ezivuthiwe nge-dilute hydrochloric acid solution ukuze ukhiphe iLycorine. Ukusetshenziswa kwe-hydrochloric acid kusiza ukukhulisa i-solubity yeLycorine, ngaleyo ndlela kuthuthukise ukusebenza kahle kokukhipha.
(4)Ukukhishwa okusizwa nge-Ultrasonic:Ukusetshenziswa kobuchwepheshe bokukhishwa okusizwa nge-ultrasonic kungasheshisa inqubo yokuchithwa kweLycorine kwi-solvent futhi kuthuthukise ukusebenza kahle kokukhishwa kanye nobumsulwa.
(5)Ukukhishwa kwe-Chloroform:I-Extraction yenziwa nge-solvents ye-organic efana ne-chloroform, futhi iLycorine idluliswa isuka esiphethini esisemanzini esigabeni se-organic ukuze sithuthukise i-complic yelitshe.
(6)Ukubuyiselwa Kwe-Solvent:Ngemuva kwenqubo yokukhishwa, i-solvent yatholakala ngokuhwamuka noma ukufakwa emanzini ukunciphisa ukusetshenziswa kwe-solvent futhi kuthuthukise umnotho.
(7)Ukuhlanzwa nokomisa:Ngokuhlanjululwa okufanele nezinyathelo zokomisa, kutholakala i-lyrochloride powder emsulwa.
Kuyo yonke inqubo yokukhishwa, okulawula ukukhethwa kwe-solvent, izimo zokukhipha (njengenani le-PH, izinga lokushisa, nesikhathi esilandelayo), nezinyathelo ezilandelayo zokuhlanza kuyisihluthulelo sokwenza ubumsulwa be-solvent kanye nokwenza ngcono izinga lokuthola kabusha. Ukusetshenziswa kwemishini yesimanjemanje yokuhlanza nemishini yokuhlanza, njengokukhishwa kwe-ultrasonic kanye nezinhlelo eziphezulu ze-chromatography (HPLC), kuyasiza ukuthuthukisa ukusebenza kahle kokukhipha kanye nekhwalithi yomkhiqizo.
Isitoreji: Gcina endaweni epholile, eyomile, nehlanzekile, ukuvikela kumswakama nokukhanya okuqondile.
Iphakheji le-Bulk: 25kg / Drum.
Isikhathi sokuhola: izinsuku eziyi-7 ngemuva kwe-oda lakho.
Impilo yesheluphelo: iminyaka emi-2.
Ukuphawula: Ukucaciswa okwenziwe ngezifiso nakho kungatholakala.
Khama
Ngaphansi kwe-100kg, 3-5days
Umnyango wesevisi emnyango kulula ukukhetha izimpahla
Ngolwandle
Ngaphezulu300kg, cishe izinsuku ezingama-30
IPort to Port Service Professional Sholearance Broker edingekayo
Ngomoya
I-100kg-1000kg, 5-7days
Isikhumulo sezindiza esikhumulweni sezindiza i-Professional Professional Professional Broker edingekayo
I-Bioway Organic isizuze i-USDA ne-EU Organic, BRC, ISO, Halal, Kosher, Nezitifiketi ze-HACCP.
I-Lycorine i-alkaloid eyenzeka ngokwemvelo etholakala ezitshalweni eziningana, ikakhulukazi ngaphakathi komndeni we-Amaryllidaceae. Nazi ezinye izitshalo ezaziwa ziqukethe iLycorine:
ILycoris radiata(eyaziwa nangokuthi isicabucabu esibomvu noma i-manjushage) iyimbamba yendabuko yamaShayina yezokwelapha equkethe iLycorine.
Lecojum aestivum(I-Summer Snowflake), iyaziwa futhi ukuthi iqukethe iLycorine.
UNGERNERIA Seetertzowiikungenye yezitshalo ezivela emndenini we-Amaryllidaceae okubikwe ukuthi uqukethe iLycorine.
I-Hippeastrum Hybrid (i-Easter Lily)nezinye izitshalo ezihlobene ze-Amaryllidaceae ziyaziwa imithombo yeLycorine.
Lezi zitshalo zisatshalaliswa kabanzi ezindaweni ezishisayo nezisezingeni eliphansi emhlabeni wonke futhi zinomlando omude wokusebenzisa umuthi wendabuko. Ukuba khona kweLycorine kulezi zitshalo kube yindaba yocwaningo ngenxa yezakhiwo zayo ezingaba khona, kufaka phakathi imiphumela yayo ebalulekile yezimo zangaphandle njengoba kuboniswe ezifundweni ezahlukahlukene.
I-Lycorine i-alkaloid yemvelo enobubanzi bemiphumela yekhemisi, kufaka phakathi ukusetshenziswa kwayo okungaba khona ekwelashweni komdlavuza. Ngenkathi kubonisile imiphumela ethembisayo ezifundweni ezahlukahlukene, kukhona eminye imiphumela emibi kanye nokucatshangelwa okuhambisana nokusetshenziswa kwayo:
Ubuthi obuphansi: I-Lycorine kanye nosawoti wayo we-hydrochloride ngokuvamile ukukhombisa ubuthi obuphansi, okuyisici esihle sezicelo zemitholampilo. Kuboniswe ukuthi kube nemiphumela emincane emibi kumaseli ajwayelekile omuntu namagundane anempilo, ephakamisa izinga elithile lokukhetha amaseli womdlavuza ngezicubu ezijwayelekile.
Imiphumela emnandi ye-Emetic: Isicanucanu se-tranceent kanye nokuhlanza sebebonwa kulandela umjovo we-vorine hydrochloride, uvame ukwehlisa amahora angama-2,5 ngaphandle kokuthinta ukuphepha kwe-biochemical noma kwe-hematological.
Akukho moto yokuhlakulela imoto ethi: Izifundo zikhombisile ukuthi imithamo eqondile yeLycorine ayithinti ukuxhumanisa kwezimoto emagukeni, njengoba kuhlolwe ukuhlolwa kwe-rotarod, okubonisa ukuthi akuholeli ku-Central System (CNS)
Umthelela kumsebenzi we-locomotor ozenzakalelayo: emthanjeni wama-30 mg / kg, iLycorine ibonwe ukuthi ilimaze umsebenzi we-locomotor ozenzakalelayo kumagundane, njengoba kukhonjiswe ukwehla kokukhulisa indlela yokukhulisa kanye nokwanda kokungakhuli.
Ukuziphatha okujwayelekile nenhlala-kahle: umthamo we-10 mg / kg weLycorine akazange aphazamise indlela yokuziphatha okujwayelekile nenhlala-kahle yamagundane, ephakamisa ukuthi lokhu kungaba ngumthamo olungile wokuhlola ukusebenza kwezokwelapha okuzayo.
Akukho miphumela ebalulekile emzimbeni wesisindo noma isimo sempilo
Kubalulekile ukuqaphela ukuthi ngenkathi i-Lycorine ikhombisile okungenzeka ukuthi kungenzeka kube khona uphenyo lwendalo, ukuhlolwa kobuthi besikhathi eside kuyantula. Kudingeka ucwaningo olwengeziwe ukuze uqonde ngokugcwele iphrofayili yalo yokuphepha, ikakhulukazi ukusetshenziswa kwesikhathi eside nasezilungiselelweni zomtholampilo. Imiphumela emibi nokuphepha kweLycorine kungahluka ngokuya ngemithamo, indlela yokuphatha, kanye nezimpawu ezizinikele. Hlala uthintana nochwepheshe wezokunakekelwa kwempilo ngaphambi kokubheka ukusetshenziswa kwanoma yikuphi ukwengezwa okusha noma ukwelashwa.
